gene 1,962 words KG: LAMP2A
Contents

LAMP2A Gene

🧬 Gene Info
Gene SymbolLAMP2
Full NameLysosomal Associated Membrane Protein 2
AliasesLysosomal-Associated Membrane Protein 2
ChromosomeXq24
Protein FamilyLAMP family
FunctionLAMP2 encodes Lysosomal Associated Membrane Protein 2, a major lysosomal membrane glycoprotein essential for lysosomal function, autophagy, and chaperone-mediated autophagy (CMA).
Molecular Weight45 kDa
Amino Acids410 aa
PathwaysApoptosis, Autophagy, Chaperone, Lysosomal Degradation, Mtor
UniProt IDP13473
NCBI Gene ID3920
Ensembl IDENSG00000100739
OMIM309060
GeneCardsLAMP2
Human Protein AtlasLAMP2
Associated DiseasesALS, APOPTOSIS, AUTOPHAGY, Alzheimer, Cancer
Known Drugs/CompoundsRAPAMYCIN, quercetin, rapamycin, statins
InteractionsPLIN3, BECN1, GRK2, FOXO1, NR1H3, MAP3K5
KG Connections1117 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (16)

Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67
Transcriptional Autophagy-Lysosome Coupling
Score: 0.66
APOE-Dependent Autophagy Restoration
Score: 0.61
Autophagosome Maturation Checkpoint Control
Score: 0.49
Lysosomal Calcium Channel Modulation Therapy
Score: 0.49

Related Analyses (6)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived

Related Experiments (4)

Alpha-Synuclein Spreading Mechanism — Prion-Like Propagation
exploratory · proposed · Score: 0.40
Chaperone-Mediated Autophagy Dysfunction in PD - Experiment
clinical · proposed · Score: 0.40
Gene expression analysis of autophagy targets following treh
exploratory · proposed · Score: 0.85
Trehalose-induced autophagy gene expression analysis
exploratory · proposed · Score: 0.85

See Also (9)

Apoptosis Pathway in Neurodegeneration
mechanism · KG edge: associated_with
Packard Center for ALS Research
institution · KG edge: activates
ATG12 — Autophagy Related 12
gene · KG edge: activates
ATG10 Gene
gene · KG edge: activates
ar
gene · KG edge: activates

Knowledge Graph (12 edges)

LAMP2A regulates MAP1LC3B
LAMP2A regulates MCOLN1
LAMP2A regulates P62
LAMP2A regulates PPARGC1A
LAMP2A regulates SQSTM1
LAMP2A regulates TFEB
LAMP2A regulates TPP1
LAMP2A activates LGALS3
LAMP2A activates MAP1LC3B
LAMP2A activates MCOLN1