gene

LRP12

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about LRP12: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

7Connections

0Hypotheses

0Analyses

5Outgoing

2Incoming

0Experiments

0Debates

Summary

Page for LRP12 - LDL receptor family protein involved in APP processing, lipid metabolism, and neurodegenerative diseases

View on Wiki →

No AI portrait yet

🧬 Gene Info

Gene Symbol	LRP12
Full Name	Low Density Lipoprotein Receptor-Related Protein 12
Aliases	Page for LRP12
Chromosome	8q22.3
Protein Type	Receptor
Function	is a member of the LDL receptor family involved in lipoprotein metabolism, cell signaling, and synaptic function.
Primary Expression	various tissues, including brain regions critical for learning and memory [@lrpa]
Molecular Weight	182 kDa
Amino Acids	2245 aa
UniProt ID	Q9Y286
NCBI Gene ID	50767
GeneCards	LRP12
Human Protein Atlas	LRP12
Ligand-binding repeats	Multiple complement-type repeats that bind various ligands including lipoproteins, apolipoproteins, and extracellular matrix proteins
Transmembrane domain	Single-pass membrane-spanning region
Associated Diseases	Als, Alzheimer, Ms
KG Connections	7 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: LRP12 — AlphaFold Q9Y286 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (4)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    LRP12["LRP12"]
    Alzheimer{"Alzheimer"}
    LRP12 -->|"associated with"| Alzheimer
    Ms{"Ms"}
    LRP12 -->|"associated with"| Ms
    Als{"Als"}
    LRP12 -->|"associated with"| Als
    Cholesterol(["Cholesterol"])
    LRP12 -->|"associated with"| Cholesterol
    Lipid_Metabolism(["Lipid Metabolism"])
    LRP12 -->|"associated with"| Lipid_Metabolism
    neurodegeneration["neurodegeneration"]
    LRP12 -->|"implicated in"| neurodegeneration
    SOAT1["SOAT1"]
    SOAT1 -->|"associated with"| LRP12
    SORL1["SORL1"]
    SORL1 -->|"associated with"| LRP12
    style LRP12 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (5)

Target	Relation	Type	Str
Alzheimer	associated_with	disease	0.65
Ms	associated_with	disease	0.65
Als	associated_with	disease	0.65
Cholesterol	associated_with	pathway	0.60
Lipid Metabolism	associated_with	pathway	0.60

Incoming (2)

Source	Relation	Type	Str
SOAT1	associated_with	gene	0.60
SORL1	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning LRP12 in their description or question text

No additional research found