| Gene Symbol | NLRP12 |
| Full Name | NLR Family Pyrin Domain Containing 12 |
| Protein Type | Receptor |
| Function | is a member of the NOD-like receptor (NLR) family that functions primarily as a negative regulator of innate immune signaling. |
| Primary Expression | myeloid cells (monocytes, macrophages, neutrophils) and is present in brain microglia, positioning it to mo |
| Pathways | NF-κB, NF-κB signaling |
| Ensembl ID | ENSG00000142405 |
| GeneCards | NLRP12 |
| Human Protein Atlas | NLRP12 |
| TRAF2, TRAF6 | E3 ubiquitin ligases upstream of NF-κB |
| ASC | adaptor protein for inflammasome assembly |
| Caspase-1 | effector protease for inflammatory cell death (pyroptosis) |
| Associated Diseases | Autoimmune |
| Interactions | AIM2, AND, APOPTOSIS, CARD8, Caspase, Cytokine |
| KG Connections | 82 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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