protein

LYNPROTEIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about LYNPROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

Lyn — Proto Oncogene Tyrosine Protein Kinase Lyn is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.

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🔬 Protein Info

Gene Symbol	LYNPROTEIN
Chromosome	8q13.1.
Protein Type	Receptor
Function	is an important component in the neurobiology of neurodegenerative diseases.
Primary Expression	hematopoietic cells (B lymphocytes, myeloid cells, mast cells) and in microglia, where it serves as both a
Subcellular Localization	** \| Plasma membrane, Cytoplasm, Endosomes \|
Molecular Weight	56 kDa
Amino Acids	21 aa
GeneCards	LYNPROTEIN
Human Protein Atlas	LYNPROTEIN
Unique domain (residues 1-65)	Lyn-specific sequences that determine substrate specificity; contains binding sites for immune receptors
SH3 domain (residues 68-125)	Binds proline-rich sequences; autoinhibitory function
SH2 domain (residues 130-205)	Phosphotyrosine binding; regulatory interactions
C-terminal tail	Tyr508 (human) phosphorylation by CSK maintains autoinhibition
B cell receptor (BCR) signaling	Phosphorylates ITAM motifs on Ig-α/Ig-β, initiating BCR signaling cascades
Associated Diseases	cancer
Interactions	ADRB2, AKT, AMPK, CD36, ERK1, FYN
KG Connections	30 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Lyn — Proto-Oncogene Tyrosine-Protein Kinase Lyn

protein · 1145 words

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Pathway Diagram

graph TD
    LYNPROTEIN["LYNPROTEIN"]
    neurodegeneration["neurodegeneration"]
    LYNPROTEIN -->|"implicated_in"| neurodegeneration
    style LYNPROTEIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

Target	Relation	Type	Str
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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning LYNPROTEIN in their description or question text

No additional research found