Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about LIVER: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | LIVER |
| Linked Hypotheses | 4 hypotheses |
Knowledge base pages for this entity
graph TD
LIVER["LIVER"]
LIVER -->|"modulates"| Mitochondrial_Dysfunction["Mitochondrial Dysfunction"]
LR_LOXL3["LR.LOXL3"] -->|"expressed in"| LIVER
Extracellular_Vesicles["Extracellular Vesicles"] -->|"modulates"| LIVER
Tumour_Extracellular_Vesicles["Tumour Extracellular Vesicles"] -->|"targets"| LIVER
LOXL3["LOXL3"] -->|"expressed in"| LIVER
Hypothalamus["Hypothalamus"] -->|"interacts"| LIVER
MIR_375["MIR-375"] -->|"expressed in"| LIVER
Mir_375["Mir-375"] -->|"expressed in"| LIVER
CLOCK["CLOCK"] -->|"expressed in"| LIVER| Target | Relation | Type | Str |
|---|---|---|---|
| ALZHEIMER'S DISEASE | involved_in | disease | 0.95 |
| Mitochondrial Dysfunction | modulates | process | 0.75 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Optogenetic viral vector delivery via tFUS-mediated blood-br | 0.557 | Alzheimer's disease | Circuit-level neural dynamics in neurode |
| RAB27A-dependent extracellular vesicle engineering for mitoc | 0.414 | neurodegeneration | Mitochondrial transfer between astrocyte |
| Microglia-Derived Extracellular Vesicle Engineering for Targ | 0.370 | neurodegeneration | Mitochondrial transfer between neurons a |
| Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m | 0.348 | neurodegeneration | Mitochondrial transfer between astrocyte |
Scientific analyses that reference this entity
drug delivery | 2026-04-15 | 0 hypotheses
neuropharmacology | 2026-04-10 | 0 hypotheses
drug delivery | 2026-04-10 | 0 hypotheses
neuroinflammation | 2026-04-07 | 0 hypotheses
drug delivery | 2026-04-06 | 0 hypotheses
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Tumour extracellular vesicles and particles induce liver metabolic dysfunction. [PMID:37225988] | Wang G, Li J, Bojmar L, Chen H, Li Z, To | Nature | 2023 | 1 |
| Extracellular vesicles in fatty liver promote a metastatic tumor microenvironmen [PMID:37172577] | Wang Z, Kim SY, Tu W, Kim J, Xu A, Yang | Cell Metab | 2023 | 1 |
| KIF5A de novo mutation associated with myoclonic seizures and neonatal onset pro [PMID:27414745] | Rydzanicz M, Jagła M, Kosinska J, Tomasi | Clin Genet | 2017 | 1 |
| TRAK/Milton motor-adaptor proteins steer mitochondrial trafficking to axons and [PMID:23395375] | van Spronsen M, Mikhaylova M, Lipka J, S | Neuron | 2013 | 1 |
| Delineation of the TRAK binding regions of the kinesin-1 motor proteins. [PMID:24161670] | Randall TS, Moores C, Stephenson FA | FEBS Lett | 2013 | 1 |
| Rab27a and Rab27b control different steps of the exosome secretion pathway. [PMID:19966785] | Ostrowski M, Carmo NB, Krumeich S, Fange | Nat Cell Biol | 2010 | 1 |
| EVs-Mediated Intracardiac Crosstalk Mitigates Doxorubicin-Induced Cardiotoxicity [PMID:41948821] | Wang H, Chen Y, Wang T, Ye X, Zhang X et | Circ Res | 2026 | 0 |
| Autophagic extracellular vesicles: a distinct secretory route linking autophagy [PMID:41958120] | Wei H, Fu Y | Autophagy | 2026 | 0 |
| Angiopep-2-engineered extracellular vesicles derived from spinal cord injury-res [PMID:41787360] | ["Xiang S", "Qin T", "Qin Y", "Sun Y", " | Journal of nanobiotechnology | 2026 | 0 |
| hUC-MSC-derived exosomes ameliorate Alzheimer's disease pathology through lncRNA [PMID:41540476] | Zhang Y, Zhang F, Yin H, Sun Y, Wang Y, | Alzheimer's research & therapy | 2026 | 0 |
| Engineered Biomimetic Nanorobots Orchestrate Targeted Nose-to-Brain Delivery to [PMID:41607240] | ["Xu Y", "Zhao J", "Xu X", "Liu Y", "Li | Small (Weinheim an der Bergstr | 2026 | 0 |
| Engineering integrin αvβ8-targeted extracellular vesicles to deliver BDNF mRNA f [PMID:41749221] | ["Shie M", "Chiu C", "Chen Y", "Lin Y", | Journal of nanobiotechnology | 2026 | 0 |
| Case Report: Late-onset primary hemophagocytic lymphohistiocytosis leading to th [PMID:40852732] | ["Rausch J", "Herold S", "Liebh\u00e4use | Frontiers in immunology | 2025 | 0 |
| Extracellular vesicles: A new therapeutic drug for nerve injury repair. [PMID:41467441] | ["Cai J", "Ren C", "Wang C", "Shen S", " | Neural regeneration research | 2025 | 0 |
| Engineered extracellular vesicles-mediated curcumin delivery in brain microenvir [PMID:41390406] | ["Shie M", "Chen M", "Chen Y", "Huang S" | Journal of nanobiotechnology | 2025 | 0 |
| Tipifarnib Reduces Extracellular Vesicles and Protects From Heart Failure. [PMID:38847080] | Mallaredy V, Roy R, Cheng Z, Thej C, Ben | Circulation research | 2024 | 0 |
| Interruption of p38 [PMID:38481807] | ["Kim S", "Lee J", "Jung J", "Kim G", "Y | International journal of biolo | 2024 | 0 |
| Therapeutic developments in pancreatic cancer. [PMID:37798442] | ["Hu Z", "O'Reilly E"] | Nature reviews. Gastroenterolo | 2024 | 0 |
| Hepatocyte-derived MASP1-enriched small extracellular vesicles activate HSCs to [PMID:35849032] | Liu X, Tan S, Liu H, Jiang J, Wang X, Li | Hepatology (Baltimore, Md.) | 2023 | 0 |
| Autophagy and exosomes coordinately mediate quercetin's protective effects on al [PMID:36965782] | ["Chen H", "Liu J", "Peng S", "Yang G", | The Journal of nutritional bio | 2023 | 0 |