concept

PCSK9

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PCSK9: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

252Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

PCSK9 is a concept in neurodegeneration research. Key relationships include: inhibits, activates, associated with. Associated with ADH, ALS, ARM. Connected to 128 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	PCSK9
Key Genes/Proteins	LDLR, LDL-C
Related Diseases	Autosomal Dominant Hypercholesterolemia, platelet activation, leukocyte recruitment, clot formation, Als

Wiki Pages (18)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    PCSK9["PCSK9"]
    PCSK9 -->|"inhibits"| LDLR["LDLR"]
    PCSK9 -->|"activates"| platelet_activation["platelet activation"]
    PCSK9 -->|"activates"| leukocyte_recruitment["leukocyte recruitment"]
    PCSK9 -->|"activates"| clot_formation["clot formation"]
    PCSK9 -->|"regulates"| LDL_C["LDL-C"]
    PCSK9 -->|"causes"| ADH["ADH"]
    PCSK9 -->|"regulates"| serum_cholesterol_levels["serum cholesterol levels"]
    PCSK9 -->|"inhibits"| Cardiovascular["Cardiovascular"]
    PCSK9 -->|"target for"| Atherosclerosis["Atherosclerosis"]
    PCSK9 -->|"activates"| Als["Als"]
    inclisiran["inclisiran"] -->|"inhibits"| PCSK9
    evolocumab["evolocumab"] -->|"inhibits"| PCSK9
    alirocumab["alirocumab"] -->|"inhibits"| PCSK9
    base_editing["base editing"] -->|"regulates"| PCSK9
    LDLR -->|"activates"| PCSK9
    APOB["APOB"] -->|"expressed in"| PCSK9
    GENES["GENES"] -->|"expressed in"| PCSK9
    SOD1["SOD1"] -->|"inhibits"| PCSK9
    HMGB2["HMGB2"] -->|"inhibits"| PCSK9

Outgoing (150)

Target	Relation	Type	Str
LDLR	inhibits	protein	0.95
LDL-C Levels	upregulates	biomarker	0.90
Atherosclerotic Plaque Development	contributes_to	process	0.90
Platelet Activation	associated_with	process	0.85
Leukocyte Recruitment	associated_with	process	0.85
Autosomal Dominant Hypercholesterolemia	risk_factor_for	disease	0.85
platelet activation	activates	phenotype	0.75
leukocyte recruitment	activates	phenotype	0.75
clot formation	activates	phenotype	0.75
Als	associated_with	disease	0.75
Aging	therapeutic_target	disease	0.75
LDL-C	regulates	protein	0.72
ADH	causes	disease	0.72
LDL	inhibits	gene	0.70
MACROPHAGES	activates	cell_type	0.70
lipid metabolism	participates_in	pathway	0.70
Cardiovascular	inhibits	disease	0.65
Atherosclerosis	therapeutic_target	disease	0.65
Als	activates	disease	0.65
Ms	activates	disease	0.65
Cardiovascular	expressed_in	disease	0.65
Cardiac	expressed_in	disease	0.65
Als	expressed_in	disease	0.65
Als	interacts_with	disease	0.65
Aging	activates	disease	0.65
Ms	therapeutic_target	disease	0.65
Als	inhibits	disease	0.65
Ms	associated_with	disease	0.65
Neuroinflammation	inhibits	disease	0.65
Inflammation	inhibits	disease	0.65
Cancer	therapeutic_target	disease	0.65
Cardiovascular	regulates	disease	0.65
Inflammation	associated_with	disease	0.65
Aging	associated_with	disease	0.65
Cardiovascular	associated_with	disease	0.65
Atherosclerosis	associated_with	disease	0.65
Cardiovascular	therapeutic_target	disease	0.65
Tumor	activates	disease	0.65
Cardiovascular	activates	disease	0.65
Atherosclerosis	interacts_with	disease	0.65
ALS	activates	disease	0.65
ALS	expressed_in	disease	0.65
Type 2 Diabetes	associated_with	disease	0.65
Diabetes	associated_with	disease	0.65
Cardiovascular	causes	disease	0.65
Als	causes	disease	0.65
Myocardial Infarction	causes	disease	0.65
Diabetes	inhibits	disease	0.65
Cardiovascular	protects_against	disease	0.65
Hypertension	inhibits	disease	0.65

Incoming (102)

Source	Relation	Type	Str
inclisiran	inhibits	drug	0.95
evolocumab	inhibits	drug	0.72
alirocumab	inhibits	drug	0.72
LDL	regulates	gene	0.70
GLUTAMATE	targets	phenotype	0.65
LDLR	activates	gene	0.60
APOB	expressed_in	gene	0.60
GENES	expressed_in	gene	0.60
SOD1	inhibits	gene	0.60
LDLR	expressed_in	gene	0.60
HMGB2	inhibits	gene	0.60
DRP1	inhibits	gene	0.60
MITOCHONDRIAL DYSFUNCTION	activates	gene	0.60
APOPTOSIS	activates	gene	0.60
P38	activates	gene	0.60
APOE	inhibits	gene	0.60
AUTOPHAGY	inhibits	gene	0.60
OXIDATIVE STRESS	inhibits	gene	0.60
C-JUN	inhibits	gene	0.60
JUN	inhibits	gene	0.60
ICAM1	inhibits	gene	0.60
MICROGLIA	inhibits	gene	0.60
VCAM1	inhibits	gene	0.60
PER	inhibits	gene	0.60
CYTOKINES	inhibits	gene	0.60
TNF	inhibits	gene	0.60
INFLAMMATION	inhibits	gene	0.60
NEUROINFLAMMATION	inhibits	gene	0.60
LDLR	inhibits	gene	0.60
VIRAL INFECTIONS	regulates	gene	0.60
LDLR	regulates	gene	0.60
INFLAMMATION	associated_with	gene	0.60
CANCER	therapeutic_target	gene	0.60
APOC3	associated_with	gene	0.60
LDLR	associated_with	gene	0.60
DGAT2	associated_with	gene	0.60
LDLR	therapeutic_target	gene	0.60
SIRT1	therapeutic_target	gene	0.60
AMPK	therapeutic_target	gene	0.60
AKT	expressed_in	gene	0.60
APOE	activates	gene	0.60
AKT	activates	gene	0.60
ERK	activates	gene	0.60
EGF	associated_with	gene	0.60
LDLR	interacts_with	gene	0.60
EGF	inhibits	gene	0.60
GAIN	contributes_to	gene	0.60
LDL	inhibits	gene	0.60
STROKE	inhibits	gene	0.60
APOB	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

PCSK9

Understanding Entity Pages

Summary

Wiki Pages (18)

Dementia with Lewy Bodies (DLB)

Inclisiran for Lewy Body Disorders Trial

Innovent Biologics

Alnylam Pharmaceuticals

Stroke

CRISPR Gene Editing for Neurodegeneration

Amgen

LDLRAP1 — Low Density Lipoprotein Receptor Adaptor Protein 1

Clinical Trials in Parkinson's Disease

LDL Receptor Protein

Yuhan Corporation

Neuroinflammation as Cause vs Consequence in Neurodegeneration

LDLR Gene

APOE3 (Apolipoprotein E3)

Adenine Base Editing of APOE4 to APOE3 for Alzheimer's Prevention

APOB Protein