Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about MBD1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Comprehensive information about MBD1, a methyl-CpG binding domain protein involved in epigenetic gene repression, neuronal function, memory formation, and implicated in Alzheimer's disease, Parkinson's disease, and other neurodegenerative disorders.
| Gene Symbol | MBD1 |
| Full Name | Methyl-CpG Binding Domain Protein 1 |
| Chromosome | 18q21.1 |
| Protein Family | MBD (Methyl-CpG Binding Domain) |
| Function | is a critical epigenetic regulator that binds to methylated CpG dinucleotides in DNA and recruits chromatin remodeling complexes to silence gene expression. |
| Molecular Weight | ~66 kDa |
| Amino Acids | 605 aa |
| Exons | 17 |
| Pathways | Dna Methylation, epigenetic regulation |
| UniProt ID | Q9P273 |
| NCBI Gene ID | 4153 |
| Ensembl ID | ENSG00000141644 |
| OMIM | 156311 |
| GeneCards | MBD1 |
| Human Protein Atlas | MBD1 |
| Associated Diseases | neurodegeneration |
| Interactions | FOS, SDHB, C-FOS, VHL, EZH2 |
| KG Connections | 10 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
MBD1["<b>MBD1</b>"]
TREK_1["TREK-1"]
MBD1 -->|"binds"| TREK_1
TREM2["TREM2"]
MBD1 -->|"associated with"| TREM2
Als{"Als"}
MBD1 -->|"activates"| Als
FOS["FOS"]
MBD1 -->|"activates"| FOS
C_FOS["C-FOS"]
MBD1 -->|"activates"| C_FOS
SDHB["SDHB"]
MBD1 -->|"activates"| SDHB
Dna_Methylation(["Dna Methylation"])
MBD1 -->|"activates"| Dna_Methylation
neurodegeneration["neurodegeneration"]
MBD1 -->|"implicated in"| neurodegeneration
VHL["VHL"]
VHL -->|"activates"| MBD1
style MBD1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| TREK-1 | binds | protein | 0.80 |
| TREM2 | associated_with | gene | 0.70 |
| Als | activates | disease | 0.65 |
| FOS | activates | gene | 0.60 |
| SDHB | activates | gene | 0.60 |
| C-FOS | activates | gene | 0.60 |
| Dna Methylation | activates | pathway | 0.60 |
| epigenetic regulation | participates_in | pathway | 0.55 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||