gene 1,735 words KG: MBD1 2026-03-27
kind:genesection:genesstate:published
Contents

MBD1 — Methyl-CpG Binding Domain Protein 1

🧬 Gene Info
Gene SymbolMBD1
Full NameMethyl-CpG Binding Domain Protein 1
Chromosome18q21.1
Protein FamilyMBD (Methyl-CpG Binding Domain)
Functionis a critical epigenetic regulator that binds to methylated CpG dinucleotides in DNA and recruits chromatin remodeling complexes to silence gene expression.
Molecular Weight~66 kDa
Amino Acids605 aa
Exons17
PathwaysDna Methylation, epigenetic regulation
UniProt IDQ9P273
NCBI Gene ID4153
Ensembl IDENSG00000141644
OMIM156311
GeneCardsMBD1
Human Protein AtlasMBD1
Associated Diseasesneurodegeneration
InteractionsFOS, SDHB, C-FOS, VHL, EZH2
KG Connections10 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (14)

Bacterial Enzyme-Mediated Dopamine Precursor Synthesis
Score: 0.36
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67
Dual-Domain Antibodies with Engineered Fc-FcRn Affinity Modu
Score: 0.57
Competitive APOE4 Domain Stabilization Peptides
Score: 0.56
Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.52

Related Analyses (12)

Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · archived
Synaptic pruning by microglia in early AD
neurodegeneration · archived
Epigenetic clocks and biological aging in neurodegeneration
neurodegeneration · archived

Related Experiments (1)

Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40

See Also (7)

Packard Center for ALS Research
institution · KG edge: activates
VHL Gene
gene · KG edge: activates
SDHB Gene
gene · KG edge: activates
FOS Gene
gene · KG edge: activates
TREM2 Protein (Triggering Receptor Expressed on Myeloid
entity · KG edge: associated_with

Knowledge Graph (10 edges)

MBD1 activates FOS
MBD1 activates SDHB
MBD1 associated_with TREM2
MBD1 activates C-FOS
MBD1 activates Als
MBD1 activates Dna Methylation
MBD1 binds TREK-1
MBD1 participates_in epigenetic regulation
VHL activates MBD1
EZH2 interacts_with MBD1