protein

VHL

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about VHL: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

283Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

VHL is a protein involved in neurodegeneration research. Key relationships include: activates, expressed in, contributes to. Associated with ALS, Als, Cancer. Connected to 191 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	VHL
Function	is an important component in the neurobiology of neurodegenerative diseases.
Primary Expression	most tissues:
Molecular Weight	19.5 kDa
Pathways	Mtor, Pi3K, Dna Methylation, Akt, Angiogenesis
Ensembl ID	ENSG00000196511
GeneCards	VHL
Human Protein Atlas	VHL
Normoxia	VHL binds to hydroxylated HIF-α (HIF1A/HIF2A), leading to polyubiquitination and degradation
Hypoxia	HIF-α escapes hydroxylation, escapes VHL-mediated degradation, and translocates to the nucleus
Target genes	VEGF, EPO, GLUT1, and other genes involved in oxygen homeostasis[@schofield2004]
Extracellular matrix maintenance	VHL regulates fibronectin matrix assembly
Microtubule stabilization	VHL interacts with microtubules
Ciliogenesis	VHL is required for primary cilia formation
DNA repair	VHL participates in DNA damage response[@gossage2010]
Associated Diseases	ALS, CLEAR CELL RENAL CELL CARCINOMA, Cancer, Carcinoma, Cardiovascular
Interactions	MTOR, PI3K, AKT, PPP1CA, BAX, VEGF
KG Connections	283 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    VHL["VHL"]
    VHL -->|"regulates"| HIF["HIF"]
    VHL -->|"activates"| Cardiovascular["Cardiovascular"]
    VHL -->|"activates"| Cardiac["Cardiac"]
    VHL -->|"activates"| Tumor["Tumor"]
    VHL -->|"activates"| Ms["Ms"]
    VHL -->|"expressed in"| Cancer["Cancer"]
    VHL -->|"expressed in"| Carcinoma["Carcinoma"]
    VHL -->|"regulates"| Als["Als"]
    TCEB1["TCEB1"] -->|"interacts"| VHL
    MTOR["MTOR"] -->|"activates"| VHL
    IDH1["IDH1"] -->|"activates"| VHL
    PI3K["PI3K"] -->|"expressed in"| VHL
    DNA["DNA"] -->|"expressed in"| VHL
    NRF2["NRF2"] -->|"expressed in"| VHL
    KEAP1["KEAP1"] -->|"expressed in"| VHL
    P53["P53"] -->|"expressed in"| VHL
    AKT["AKT"] -->|"expressed in"| VHL

Outgoing (209)

Target	Relation	Type	Str
Clear-Cell Renal Cell Carcinoma	associated_with	disease	0.95
Clear Cell Renal Cell Carcinoma	risk_factor_for	disease	0.95
Clear Cell Renal Cell Carcinoma	drives	disease	0.95
HIF	degrades	protein	0.95
HIF1A	degrades	protein	0.93
Proteolysis	mediates	process	0.90
kidney tumorigenesis	protects_against	process	0.90
VHL-Loss-Driven phenotype	mediates	phenotype	0.90
CANCER	activates	gene	0.90
Tumor	activates	disease	0.85
Cancer	activates	disease	0.85
Carcinoma	activates	disease	0.85
Als	activates	disease	0.85
PBRM1	associated_with	gene	0.85
Kidney Cancer	causes	disease	0.80
CLEAR CELL RENAL CELL CARCINOMA	causes	disease	0.80
Mtor	activates	pathway	0.80
HIF	activates	gene	0.80
MTOR	activates	protein	0.76
MTOR Pathway Activity	associated_with	process	0.75
Als	therapeutic_target	disease	0.75
Tumor	therapeutic_target	disease	0.75
Tumor	inhibits	disease	0.75
Cancer	causes	disease	0.75
Renal Cell Carcinoma	activates	disease	0.75
mTOR	activates	protein	0.75
HIF	regulates	protein	0.72
AKT	activates	gene	0.70
AKT	contributes_to	gene	0.70
CANCER	causes	gene	0.70
Cancer	associated_with	disease	0.65
Cardiovascular	activates	disease	0.65
Carcinoma	associated_with	disease	0.65
Cardiac	activates	disease	0.65
Ms	activates	disease	0.65
Cancer	expressed_in	disease	0.65
Carcinoma	expressed_in	disease	0.65
Tumor	expressed_in	disease	0.65
Als	regulates	disease	0.65
Cardiovascular	associated_with	disease	0.65
Tumor	associated_with	disease	0.65
Tumor	regulates	disease	0.65
Ischemia	activates	disease	0.65
Stroke	activates	disease	0.65
Cancer	therapeutic_target	disease	0.65
Als	expressed_in	disease	0.65
Ms	interacts_with	disease	0.65
Ms	inhibits	disease	0.65
Tumor	causes	disease	0.65
Carcinoma	causes	disease	0.65

Incoming (74)

Source	Relation	Type	Str
ELOC	interacts_with	protein	0.90
PBRM1	interacts_with	protein	0.75
PTEN	contributes_to	gene	0.70
TCEB1	interacts_with	gene	0.64
MTOR	activates	gene	0.60
STAT3	associated_with	gene	0.60
IDH1	activates	gene	0.60
PI3K	expressed_in	gene	0.60
MTOR	expressed_in	gene	0.60
NRF2	expressed_in	gene	0.60
KEAP1	expressed_in	gene	0.60
AKT	expressed_in	gene	0.60
CUL3	expressed_in	gene	0.60
STK11	contributes_to	gene	0.60
PI3K	contributes_to	gene	0.60
AKT	contributes_to	gene	0.60
PTEN	implicated_in	gene	0.60
GAIN	causes	gene	0.60
SQSTM1	interacts_with	gene	0.60
BECLIN1	inhibits	gene	0.60
ARID1A	contributes_to	gene	0.60
PIEZO1	therapeutic_target	gene	0.60
JAK2	therapeutic_target	gene	0.60
UBIQUITIN	activates	gene	0.60
MDM2	interacts_with	gene	0.60
MDM2	regulates	gene	0.60
PHD2	interacts_with	gene	0.60
VEGF	activates	gene	0.60
SNF	causes	gene	0.60
SWI	causes	gene	0.60
HIF1	associated_with	gene	0.60
DNA	expressed_in	gene	0.60
P53	expressed_in	gene	0.60
GENES	contributes_to	gene	0.60
HIF	causes	gene	0.60
CANCER	causes	gene	0.60
TCEB1	causes	gene	0.60
CANCER	expressed_in	gene	0.60
ATG14L	inhibits	gene	0.60
INSULIN RESISTANCE	activates	gene	0.60
ACETYL-COA	contributes_to	gene	0.60
AND	associated_with	gene	0.60
PBRM1	causes	gene	0.60
AND	causes	gene	0.60
RNA	expressed_in	gene	0.60
AND	expressed_in	gene	0.60
RNA	contributes_to	gene	0.60
AND	contributes_to	gene	0.60
CANCER	activates	gene	0.60
ACLY	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

VHL

Understanding Entity Pages

Summary

Wiki Pages (21)

VHL Gene

Novel Therapy Index

ubiquitin-proteasome-dysfunction-neurodegeneration

FBXO7 — F-Box Protein 7

epas1-protein

PROTAC Therapy for Parkinson's Disease

BBB-Transcytosis Shuttle for Episodic CNS PROTAC Delivery

Tau PROTAC and Degraders - Targeted Protein Degradation for Tau

Tau-PROTAC Heterobifunctional Degrader for Tauopathy

Targeted Protein Degradation (PROTACs)

Hypoxia Response Pathway

Novel Therapeutic Modalities Synthesis

PLK2 Gene

Golgi Apparatus Dysfunction Pathway

E3 Ubiquitin Ligase System in Neurodegeneration

HIF1AN — Hypoxia Inducible Factor 1 Subunit Alpha Inhibitor

HIF/Hypoxia Signaling in Parkinson's Disease