protein

MIRO1PROTEIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MIRO1PROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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🔬 Protein Info

Gene Symbol	MIRO1PROTEIN
Target Class	Signaling Protein
Function	is a mitochondrial Rho GTPase protein of approximately 71 kDa that plays critical roles in regulating mitochondrial transport, calcium homeostasis, mitochondrial dynamics, and quality control in ne...
Mechanism of Action	MIRO1-targeting drugs modulate GTPase activity to enhance mitochondrial transport along axons and improve mitochondrial quality control through selective autophagy. By regulating MIRO1's interaction with kinesin motor proteins and PINK1-mediated mitophagy, these compounds restore energy homeostasis and reduce neuronal stress in neurodegenerative diseases.
Subcellular Localization	</strong></td><td>Mitochondrial outer membrane (N-terminus in cytosol)</td></tr>
Druggability	Low (0.29)
Clinical Stage	Phase II
Molecular Weight	71 kDa
GeneCards	MIRO1PROTEIN
Human Protein Atlas	MIRO1PROTEIN
Associated Diseases	AD, Aging, ALI, Als, Alzheimer
Known Drugs/Compounds	Miro-inhibitor-001, GTPASE-mod-42, Mitochondrial transport enhancer XR-789, MIRO1-stabilizing compound MRS-2
Interactions	ABCD3, Actin, ALS, ALZHEIMER, ALZHEIMER DISEASE, ALZHEIMER'S DISEASE
SciDEX Target	View Target Profile (8 clinical trials)
SciDEX Hypotheses	Mitochondrial Transfer Pathway Enhancement
KG Connections	1097 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Miro1 Protein

protein · 1463 words

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Pathway Diagram

graph TD
    MIRO1PROTEIN["MIRO1PROTEIN"]
    neurodegeneration["neurodegeneration"]
    MIRO1PROTEIN -->|"implicated_in"| neurodegeneration
    style MIRO1PROTEIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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Mentioning Analyses (0)

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Experiments (0)

Experimental studies targeting or related to this entity

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Related Papers (0)

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Debates (0)

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