Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about mme: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | MME |
| Aliases | Neprilysin/CD10 |
| Chromosome | 3q25.2 |
| Protein Type | Protease |
| Amino Acids | 750 aa |
| Exons | 24 |
| Ensembl ID | ENSG00000196549 |
| GeneCards | MME |
| Human Protein Atlas | MME |
| Degrades Aβ40 and Aβ42 | the primary pathogenic peptides in alzheimers — by cleaving at multiple sites within the peptide |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
MME["MME"]
MME -->|"regulates"| Alzheimer["Alzheimer"]
MME -->|"regulates"| Als["Als"]
MME -->|"regulates"| ALS["ALS"]
MME -->|"regulates"| ALZHEIMER["ALZHEIMER"]
MME -->|"regulates"| ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
MME -->|"regulates"| Hemoglobin["Hemoglobin"]
MME -->|"implicated in"| neurodegeneration["neurodegeneration"]
ALZHEIMER -->|"regulates"| MME| Target | Relation | Type | Str |
|---|---|---|---|
| benchmark_ot_ad_answer_key:MME | data_in | dataset_row | 0.00 |
| ALS | regulates | disease | 0.65 |
| Alzheimer | regulates | disease | 0.65 |
| Als | regulates | disease | 0.65 |
| ALZHEIMER'S DISEASE | regulates | gene | 0.60 |
| GAPDH | associated_with | gene | 0.60 |
| RNA | associated_with | gene | 0.60 |
| ALZHEIMER | regulates | gene | 0.60 |
| HBB | associated_with | gene | 0.60 |
| frontotemporal dementia | associated_with | disease | 0.60 |
| SORL1 | associated_with | gene | 0.60 |
| Hemoglobin | regulates | protein | 0.60 |
| PARK7 | associated_with | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Seed-Proximal Asymmetric Duplex Stability Confers lncRNA-002 | 0.733 | molecular-neurobiology | How does lncRNA-0021 achieve sequence-sp |
| Neuronal TET1 Upregulation Reactivates Immediate-Early Genes | 0.640 | neurodegeneration | epigenetic reprogramming aging neurons |
| Butyrate-Producing Commensal Depletion Creates Vicious Cycle | 0.630 | neurodegeneration | How does gut microbiome dysbiosis contri |
| Charge-Pattern Asymmetry Creates Electrostatic Recruitment G | 0.523 | molecular-biology | What physicochemical properties determin |
| Phosphatidylserine Decarboxylase (PISD) Restoration to Corre | 0.342 | lipidomics | Lipid metabolism dysregulation in Alzhei |
| Tau-Induced Lipid Membrane Asymmetry Exploitation | 0.000 | - | How can ESCRT or SNARE targeting achieve |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-15 | 2 hypotheses Top: 0.634
neurodegeneration | 2026-04-11 | 0 hypotheses
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
closed · Rounds: 4 · Score: 0.30 · 2026-04-21
closed · Rounds: 4 · Score: 0.68 · 2026-04-15
Hypotheses and analyses mentioning mme in their description or question text