gene

PARK7

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PARK7: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

608Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

PARK7 is a gene implicated in neurodegeneration research. Key relationships include: associated with, contributes to, interacts with. Associated with AD, ALS, Aging. Connected to 157 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	PARK7
Full Name	Parkinsonism Associated Deglycase (DJ-1)
Aliases	Page for PARK7 Gene
Chromosome	1p36.23
Protein Type	Protein
Function	DJ-1 has multiple cellular functions
Primary Expression	High in brain (substantia nigra), testis, kidney
Subcellular Localization	Cytoplasm, nucleus, mitochondria
Molecular Weight	20 kDa
Amino Acids	189 aa
Pathways	Alpha-Synuclein, Autophagy, Epigenetic, Er Stress, Inflammasome
UniProt ID	Q99497
GeneCards	PARK7
Human Protein Atlas	PARK7
Associated Diseases	AD, Als, Alzheimer, Alzheimer's disease, Amyotrophic Lateral Sclerosis
Interactions	ACETYL-COA, AD, AGING, AKT, Alpha-Synuclein, ALS
KG Connections	608 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: PARK7 — AlphaFold Q99497 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (12)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    PARK7["PARK7"]
    PARK7 -->|"causes"| PD["PD"]
    PARK7 -->|"regulates"| Neurodegeneration["Neurodegeneration"]
    PARK7 -.biomarker for.-> Alzheimer["Alzheimer"]
    PARK7 -.biomarker for.-> Ms["Ms"]
    PARK7 -.biomarker for.-> Als["Als"]
    PARK7 -->|"contributes to"| Parkinson["Parkinson"]
    PARK7 -->|"interacts"| Aging["Aging"]
    SOD1["SOD1"] -->|"regulates"| PARK7
    VPS35["VPS35"] -->|"contributes to"| PARK7
    LRRK2["LRRK2"] -->|"contributes to"| PARK7
    GBA1["GBA1"] -->|"contributes to"| PARK7
    GENES["GENES"] -->|"contributes to"| PARK7
    DNA["DNA"] -->|"target for"| PARK7
    PINK1["PINK1"] -->|"contributes to"| PARK7
    PRKN["PRKN"] -->|"contributes to"| PARK7
    DNM1L["DNM1L"] -.biomarker for.-> PARK7
    FIS1["FIS1"] -.biomarker for.-> PARK7

Outgoing (321)

Target	Relation	Type	Str
Parkinson's Disease	associated_with	disease	0.95
Parkinson's Disease	causes	disease	0.95
proteostasis	regulates	process	0.85
neurodegeneration	associated_with	phenotype	0.85
oxidative stress	suppresses	process	0.85
Alzheimer's Disease	biomarker_for	disease	0.85
Neurodegeneration	associated_with	process	0.85
Als	associated_with	disease	0.75
PD	causes	disease	0.72
TFEB	activates	gene	0.70
SIRT1	activates	gene	0.70
TRAF6	activates	gene	0.70
TNF	activates	gene	0.70
SYNJ1	associated_with	gene	0.70
ULK1	activates	gene	0.70
SOD1	activates	gene	0.70
SQSTM1	activates	gene	0.70
STING	associated_with	gene	0.70
PINK1	protects_against	gene	0.70
GENES	associated_with	gene	0.70
SNCA	associated_with	gene	0.70
PRKN	associated_with	gene	0.70
oxidative stress response	participates_in	pathway	0.70
PRKN	interacts_with	gene	0.70
stem cells	expressed_in	cell_type	0.70
SYNJ1	interacts_with	gene	0.70
Spinocerebellar Ataxia	expressed_in	disease	0.65
Parkinson	activates	disease	0.65
ALS	activates	disease	0.65
Ataxia	expressed_in	disease	0.65
Inflammation	contributes_to	disease	0.65
Inflammation	causes	disease	0.65
Inflammation	activates	disease	0.65
Als	expressed_in	disease	0.65
Huntington	associated_with	disease	0.65
Huntington	expressed_in	disease	0.65
Ms	causes	disease	0.65
Als	regulates	disease	0.65
Parkinson	causes	disease	0.65
ALS	regulates	disease	0.65
Autism	regulates	disease	0.65
apoptosis	co_discussed	process	0.65
Alzheimer	associated_with	disease	0.65
Melanoma	associated_with	disease	0.65
Cancer	associated_with	disease	0.65
Amyotrophic Lateral Sclerosis	associated_with	disease	0.65
Ms	regulates	disease	0.65
SNCA	interacts_with	gene	0.65
PARKIN	interacts_with	gene	0.65
Parkinson	expressed_in	disease	0.65

Incoming (287)

Source	Relation	Type	Str
BECN1	associated_with	gene	0.70
NEURONS	activates	cell_type	0.70
NFKB	activates	gene	0.70
NRF2	activates	gene	0.70
AMPK	activates	gene	0.70
DOPAMINERGIC	associated_with	cell_type	0.70
ATP13A2	causes	gene	0.70
KEAP1	activates	gene	0.70
BECN1	activates	gene	0.70
NEP	associated_with	gene	0.70
APP	activates	gene	0.70
ENDOTHELIAL	activates	cell_type	0.70
GBA	activates	gene	0.70
LRRK2	activates	gene	0.70
MACROPHAGE	activates	cell_type	0.70
NLRP3	associated_with	gene	0.70
NRF2	associated_with	gene	0.70
LRRK2	protects_against	gene	0.70
ATP13A2	interacts_with	gene	0.70
FBXO7	interacts_with	gene	0.70
GBA1	interacts_with	gene	0.70
ALZHEIMER	associated_with	gene	0.70
DNAJC6	interacts_with	gene	0.70
LRRK2	associated_with	gene	0.70
ATP13A2	associated_with	gene	0.65
NRF2	co_discussed	gene	0.65
AUTOPHAGY	associated_with	gene	0.65
MTOR	interacts_with	gene	0.65
FBXO7	co_discussed	gene	0.65
LMNA	associated_with	gene	0.60
CLOCK	interacts_with	gene	0.60
SDHB	interacts_with	gene	0.60
PPARG	interacts_with	gene	0.60
GBA1	associated_with	gene	0.60
PGC1A	interacts_with	gene	0.60
ATP5F1	interacts_with	gene	0.60
PARK1	causes	gene	0.60
ALPHA-SYNUCLEIN	co_discussed	gene	0.60
NEURON	associated_with	gene	0.60
DEPRESSION	associated_with	gene	0.60
ALS	co_discussed	gene	0.60
HD	co_discussed	gene	0.60
MITOPHAGY	activates	pathway	0.60
NEURON	activates	cell_type	0.60
VPS35	associated_with	gene	0.60
SIRT3	associated_with	gene	0.60
PINK1	associated_with	gene	0.60
PRKN	associated_with	gene	0.60
SNCA	associated_with	gene	0.60
APP	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning PARK7 in their description or question text

No additional research found

PARK7

Understanding Entity Pages

Summary

Wiki Pages (12)

PARK7 — Parkinsonism Associated Deglycase (DJ-1)

PARK7 (DJ-1) Targeted Therapy for Parkinson's Disease

DJ-1/PARK7 Neuroprotection Pathway in Parkinson's Disease

PARK7/DJ-1 Neuroprotection Pathway — Parkinson's Disease Causal Chain

PARK7 — Parkinsonism Associated Deglycase (DJ-1)

DJ-1 Protein (PARK7)

GPR37 (PARK7) Neurons

PARK7 Gene - DJ-1/PARK7

DJ1 (PARK7)

DJ-1 (PARK7) Neuroprotective Therapies

PARK7 (DJ-1) Protein

PARK7 Protein (DJ-1)