gene

PARK7

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PARK7: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

549Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

PARK7 is a gene implicated in neurodegeneration research. Key relationships include: associated with, contributes to, interacts with. Associated with AD, ALS, Aging. Connected to 157 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	PARK7
Full Name	Parkinsonism Associated Deglycase (DJ-1)
Aliases	Page for PARK7 Gene
Chromosome	1p36.23
Protein Type	Protein
Function	DJ-1 has multiple cellular functions
Primary Expression	High in brain (substantia nigra), testis, kidney
Subcellular Localization	Cytoplasm, nucleus, mitochondria
Molecular Weight	20 kDa
Amino Acids	189 aa
Pathways	Alpha-Synuclein, Autophagy, Epigenetic, Er Stress, Inflammasome
UniProt ID	Q99497
NCBI Gene ID	11315
Ensembl ID	ENSG00000116288
OMIM	602533
GeneCards	PARK7
Human Protein Atlas	PARK7
Associated Diseases	AD, ALS, Alzheimer, Alzheimer's disease, Amyotrophic Lateral Sclerosis
Interactions	BACE1, OPTINEURIN, NURR1, PINK1, SFPQ, PARKIN
KG Connections	549 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: PARK7 — AlphaFold Q99497 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    PARK7["PARK7"]
    PARK7 -->|"causes"| PD["PD"]
    PARK7 -->|"regulates"| Neurodegeneration["Neurodegeneration"]
    PARK7 -.biomarker for.-> Alzheimer["Alzheimer"]
    PARK7 -.biomarker for.-> Ms["Ms"]
    PARK7 -.biomarker for.-> Als["Als"]
    PARK7 -->|"contributes to"| Parkinson["Parkinson"]
    PARK7 -->|"interacts"| Aging["Aging"]
    SOD1["SOD1"] -->|"regulates"| PARK7
    VPS35["VPS35"] -->|"contributes to"| PARK7
    LRRK2["LRRK2"] -->|"contributes to"| PARK7
    GBA1["GBA1"] -->|"contributes to"| PARK7
    GENES["GENES"] -->|"contributes to"| PARK7
    DNA["DNA"] -->|"target for"| PARK7
    PINK1["PINK1"] -->|"contributes to"| PARK7
    PRKN["PRKN"] -->|"contributes to"| PARK7
    DNM1L["DNM1L"] -.biomarker for.-> PARK7
    FIS1["FIS1"] -.biomarker for.-> PARK7

Outgoing (324)

Target	Relation	Type	Str
Parkinson's Disease	causes	disease	0.95
Parkinson's Disease	contributes_to	disease	0.95
proteostasis	regulates	process	0.85
Neurodegeneration	associated_with	process	0.85
Alzheimer's Disease	biomarker_for	disease	0.85
oxidative stress	suppresses	process	0.85
Als	contributes_to	disease	0.75
PD	causes	disease	0.72
PRKN	associated_with	gene	0.70
SNCA	associated_with	gene	0.70
PRKN	interacts_with	gene	0.70
SYNJ1	interacts_with	gene	0.70
GENES	contributes_to	gene	0.70
stem cells	expressed_in	cell_type	0.70
oxidative stress response	participates_in	pathway	0.70
PARKIN	interacts_with	gene	0.65
SNCA	interacts_with	gene	0.65
LAMP2	causes	gene	0.65
NRF2	regulates	gene	0.65
Neurodegeneration	regulates	disease	0.65
Alzheimer	biomarker_for	disease	0.65
Ms	biomarker_for	disease	0.65
Als	biomarker_for	disease	0.65
Parkinson	contributes_to	disease	0.65
Alzheimer	interacts_with	disease	0.65
Aging	interacts_with	disease	0.65
Als	interacts_with	disease	0.65
Huntington	interacts_with	disease	0.65
Parkinson	interacts_with	disease	0.65
Ms	interacts_with	disease	0.65
ALS	biomarker_for	disease	0.65
ALS	contributes_to	disease	0.65
Ms	associated_with	disease	0.65
Parkinson	associated_with	disease	0.65
Als	associated_with	disease	0.65
Cancer	associated_with	disease	0.65
Melanoma	associated_with	disease	0.65
Parkinson	expressed_in	disease	0.65
Amyotrophic Lateral Sclerosis	associated_with	disease	0.65
Neurodegeneration	contributes_to	disease	0.65
Alzheimer	associated_with	disease	0.65
Alzheimer	regulates	disease	0.65
Parkinson	regulates	disease	0.65
Ms	regulates	disease	0.65
Als	regulates	disease	0.65
Ms	causes	disease	0.65
Parkinson	causes	disease	0.65
Huntington	associated_with	disease	0.65
Als	expressed_in	disease	0.65
Huntington	expressed_in	disease	0.65

Incoming (225)

Source	Relation	Type	Str
LRRK2	associated_with	gene	0.70
ATP13A2	interacts_with	gene	0.70
DNAJC6	interacts_with	gene	0.70
FBXO7	interacts_with	gene	0.70
GBA1	interacts_with	gene	0.70
ALZHEIMER	associated_with	gene	0.70
ATP13A2	associated_with	gene	0.65
MTOR	interacts_with	gene	0.65
FBXO7	co_discussed	gene	0.65
NRF2	co_discussed	gene	0.65
AUTOPHAGY	associated_with	gene	0.65
SOD1	regulates	gene	0.60
VPS35	contributes_to	gene	0.60
LRRK2	contributes_to	gene	0.60
GBA1	contributes_to	gene	0.60
PINK1	contributes_to	gene	0.60
PRKN	contributes_to	gene	0.60
LRRK2	co_discussed	gene	0.60
CD8	associated_with	gene	0.60
DNM1L	biomarker_for	gene	0.60
FIS1	biomarker_for	gene	0.60
SIRT3	associated_with	gene	0.60
PGC1A	interacts_with	gene	0.60
ATP5F1	interacts_with	gene	0.60
LMNA	associated_with	gene	0.60
CLOCK	interacts_with	gene	0.60
SDHB	interacts_with	gene	0.60
PPARG	interacts_with	gene	0.60
SNCA	associated_with	gene	0.60
TAU	regulates	gene	0.60
PINK1	associated_with	gene	0.60
PARK2	associated_with	gene	0.60
PGK1	expressed_in	gene	0.60
SAMHD1	associated_with	gene	0.60
SNCA	regulates	gene	0.60
MTOR	regulates	gene	0.60
PINK1	activates	gene	0.60
PARKIN	activates	gene	0.60
PRKN	causes	gene	0.60
SNCA	contributes_to	gene	0.60
HNRNPA1	regulates	gene	0.60
PSMB5	contributes_to	gene	0.60
ATXN2	expressed_in	gene	0.60
GCH1	associated_with	gene	0.60
VPS35	associated_with	gene	0.60
GBA1	associated_with	gene	0.60
TARDBP	associated_with	gene	0.60
PARK2	expressed_in	gene	0.60
UBIQUITIN	associated_with	gene	0.60
PARKIN	expressed_in	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

PARK7

Understanding Entity Pages

Summary

Wiki Pages (21)

PARK7 — Parkinsonism Associated Deglycase (DJ-1)

Parkinson's Disease

neuroinflammation

Mitochondrial Quality Control

Mitochondrial Dysfunction in Parkinson's Disease

substantia-nigra

ATP13A2 Lysosomal Dysfunction Pathway in Parkinson's Disease

LRRK2 G2019S

sporadic-familial-pd-comparison

pink1-parkin-mitophagy-pd-causal-chain

Ferroptotic Neurons

DJ-1 Oxidative Stress Response Pathway in Parkinson's Disease

AIFM1 Gene

BAG5 Gene

ATP13A2 — ATPase Cation Transporting 13A2

Autophagy-Lysosomal Pathway in Parkinson's Disease

SNCA A53T

Parkinson's Disease Mechanisms

mitochondrial-dysfunction-neurodegeneration-comparison