Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about MPZ: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
MPZ is a gene implicated in neurodegeneration research. Key relationships include: interacts with, regulates, inhibits. Connected to 12 entities in the SciDEX knowledge graph.
| Gene Symbol | MPZ |
| Full Name | Myelin Protein Zero |
| Chromosome | 1q23.3 |
| Function | The MPZ gene encodes myelin protein zero (also known as P0), a critical structural protein of the peripheral nervous system myelin sheath. |
| Primary Expression | Peripheral nervous system, Schwann cells |
| UniProt ID | P07846 |
| NCBI Gene ID | 4240 |
| Ensembl ID | ENSG00000156675 |
| OMIM | 159440 |
| GeneCards | MPZ |
| Human Protein Atlas | MPZ |
| Symbol [@omim] MPZ [@uniprot] Full Name | Myelin Protein Zero |
| Associated Diseases | Charcot-Marie-Tooth Disease, Dejerine-Sottas Syndrome |
| Interactions | PMP22, SHP-2, DAF-18, Arf proteins, MBP |
| KG Connections | 22 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
MPZ["<b>MPZ</b>"]
PMP22["PMP22"]
MPZ -->|"interacts with"| PMP22
SHP_2["SHP-2"]
MPZ -->|"interacts with"| SHP_2
Src_kinases["Src kinases"]
MPZ -->|"interacts with"| Src_kinases
DAF_2["DAF-2"]
MPZ -->|"regulates"| DAF_2
DAF_16["DAF-16"]
MPZ -->|"regulates"| DAF_16
DAF_18["DAF-18"]
MPZ -->|"interacts with"| DAF_18
Egr2["Egr2"]
MPZ -->|"regulates"| Egr2
Sox10["Sox10"]
MPZ -->|"interacts with"| Sox10
Krox20["Krox20"]
MPZ -->|"regulates"| Krox20
Arf_proteins["Arf proteins"]
MPZ -->|"interacts with"| Arf_proteins
neurodegeneration["neurodegeneration"]
MPZ -->|"implicated in"| neurodegeneration
shRNA["shRNA"]
shRNA -->|"inhibits"| MPZ
style MPZ fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Dejerine-Sottas Syndrome | causes | disease | 0.95 |
| Charcot-Marie-Tooth Disease | implicated_in | disease | 0.95 |
| PMP22 | interacts_with | gene | 0.90 |
| SHP-2 | interacts_with | protein | 0.80 |
| Src kinases | interacts_with | enzyme | 0.80 |
| DAF-2 | regulates | gene | 0.80 |
| DAF-18 | interacts_with | gene | 0.80 |
| Egr2 | regulates | transcription_factor | 0.80 |
| Sox10 | interacts_with | transcription_factor | 0.80 |
| DAF-16 | regulates | gene | 0.80 |
| Krox20 | regulates | transcription_factor | 0.70 |
| Arf proteins | interacts_with | protein | 0.70 |
| neurodegeneration | activates | disease | 0.60 |
| PMP22 | causes | gene | 0.60 |
| TTR | causes | gene | 0.60 |
| oligodendrocytes | expressed_in | cell_type | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||