gene

MFN2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MFN2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

729Connections

0Hypotheses

1Analyses

50Outgoing

50Incoming

Summary

MFN2 is a gene implicated in neurodegeneration research. Key relationships include: activates, inhibits, regulates. Associated with Aging, Als, Alzheimer. Connected to 320 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	MFN2
Aliases	Mitofusin 2
Chromosome	1p36.22
Function	Trans-tethering: HR2 domains form antiparallel complexes between adjacent mitochondria
Molecular Weight	84 kDa
Amino Acids	757 aa
Exons	17
Pathways	NF-κB, AMPK
GeneCards	MFN2
Human Protein Atlas	MFN2
Feature	MFN2
Tissue expression	Broad, high in muscle
GTPase activity	Higher
ER contacts	Yes
Mitophagy role	Major
Associated Diseases	Als, CHARCOT-MARIE-TOOTH, Charcot-Marie-Tooth Type 2A, Fibrosis, Hereditary Polyneuropathy, Huntington
Known Drugs/Compounds	8015-P2, Piperine
Interactions	GSDMD, RIPK1, RAB7A, CAT, CCR5, APP
KG Connections	729 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    MFN2["MFN2"]
    MFN2 -->|"regulates"| Ms["Ms"]
    MFN2 -->|"activates"| Inflammation["Inflammation"]
    MFN2 -->|"expressed in"| Hepatitis["Hepatitis"]
    MFN2 -->|"inhibits"| Cancer["Cancer"]
    MFN2 -->|"contributes to"| Als["Als"]
    MFN2 -->|"interacts"| Dementia["Dementia"]
    PGC_1_["PGC-1alpha"] -->|"regulates"| MFN2
    OPA1["OPA1"] -->|"regulates"| MFN2
    BAX["BAX"] -->|"activates"| MFN2
    DRP1["DRP1"] -->|"activates"| MFN2
    FADD["FADD"] -->|"activates"| MFN2
    NRF2["NRF2"] -->|"activates"| MFN2
    ABCG2["ABCG2"] -->|"activates"| MFN2
    ZBP1["ZBP1"] -->|"activates"| MFN2

Outgoing (489)

Target	Relation	Type	Str
Charcot-Marie-Tooth Type 2A	associated_with	disease	0.98
Mitochondrial Quality Control	involved_in	process	0.95
Mitochondrial Dynamics	involved_in	process	0.95
Mitochondrial Dynamics	regulates	process	0.95
VIP Neurons	expressed_in	cell_type	0.95
ER Tethering	regulates	process	0.95
Mitochondrial Transport	regulates	process	0.92
Alpha-Tubulin Acetylation	modulates	process	0.92
ER-mitochondria juxtaposition	modulates	process	0.90
Mitochondrial fusion	activates	process	0.90
Mitochondrial Fusion	regulates	process	0.90
Circadian Rhythms	regulates	process	0.90
Synaptic Dynamics	regulates	process	0.90
Ciliary Gene Expression	regulates	process	0.90
Sensory-Motor Neuropathy	involved_in	disease	0.90
ATAT1	interacts_with	enzyme	0.90
Hereditary Polyneuropathy	implicated_in	disease	0.90
Mitophagy	activates	pathway	0.90
Mitochondrial Fusion	mediates	process	0.88
mitochondrial DNA release	regulates	process	0.85
autophagy	regulates	process	0.85
Mitochondrial Fusion	promotes	process	0.85
CROCC	regulates	gene	0.85
Mitochondrial dysfunction	protects_against	process	0.85
Axonal Transport	regulates	process	0.85
Als	activates	disease	0.85
Alzheimer's Disease	biomarker_for	disease	0.85
mitochondrial dysfunction	contributes_to	process	0.85
Mitochondrial Dysfunction	contributes_to	phenotype	0.85
SLC27A2	interacts_with	protein	0.80
mitochondrial dynamics	participates_in	pathway	0.80
Mitochondrial Dysfunction	regulates	process	0.80
OPA1	inhibits	gene	0.80
MITOCHONDRIA	activates	gene	0.80
Inflammation	activates	disease	0.75
Als	expressed_in	disease	0.75
Cardiac	activates	disease	0.75
Cancer	regulates	disease	0.75
Parkinson	activates	disease	0.75
Neurodegeneration	associated_with	process	0.75
MTOR	regulates	gene	0.70
TFAM	activates	gene	0.70
NRF2	activates	gene	0.70
PINK1	inhibits	gene	0.70
SIRT3	activates	gene	0.70
UBIQUITIN	activates	gene	0.70
MTOR	activates	gene	0.70
MFN1	inhibits	gene	0.70
mitochondrial fusion	promotes	process	0.70
Mtor	regulates	pathway	0.70

Incoming (240)

Source	Relation	Type	Str
Palmitic Acid	downregulates	compound	0.90
DIZE	upregulates	drug	0.90
8015-P2	activates	compound	0.90
PINK1-PRKN-dependent mitophagy	interacts_with	process	0.88
Paclitaxel	downregulates	drug	0.85
miR-17-5p	regulates	compound	0.85
SelH	regulates	gene	0.80
AMPK	interacts_with	gene	0.80
PINK1	activates	gene	0.80
MITOPHAGY	activates	gene	0.80
Piperine	targets	compound	0.75
Zn	activates	drug	0.70
PGC-1α	regulates	protein	0.70
APOPTOSIS	implicated_in	gene	0.70
PINK1	treats	gene	0.65
OPA1	regulates	gene	0.60
BAX	activates	gene	0.60
DRP1	activates	gene	0.60
FADD	activates	gene	0.60
NRF2	activates	gene	0.60
ABCG2	activates	gene	0.60
ZBP1	activates	gene	0.60
FIS1	activates	gene	0.60
MMP9	associated_with	gene	0.60
RELA	expressed_in	gene	0.60
OPA1	associated_with	gene	0.60
P62	expressed_in	gene	0.60
DRP1	inhibits	gene	0.60
PARKIN	activates	gene	0.60
P62	activates	gene	0.60
RAB5C	regulates	gene	0.60
RAB7A	activates	gene	0.60
MFN1	activates	gene	0.60
GFAP	activates	gene	0.60
DRP1	biomarker_for	gene	0.60
MFN1	biomarker_for	gene	0.60
DRP1	regulates	gene	0.60
MFN1	regulates	gene	0.60
NRF1	regulates	gene	0.60
NRF1	activates	gene	0.60
OPA1	activates	gene	0.60
AKT	activates	gene	0.60
MFN1	inhibits	gene	0.60
OPA1	inhibits	gene	0.60
LARS2	inhibits	gene	0.60
STX17	associated_with	gene	0.60
ATP5MC1	regulates	gene	0.60
TXNRD1	regulates	gene	0.60
BNIP3	inhibits	gene	0.60
VDAC1	inhibits	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Mitochondrial transfer between astrocytes and neurons

neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.570

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

MFN2

Understanding Entity Pages

Summary

Wiki Pages (21)

mfn2

Mitochondrial Quality Control

Mitochondrial Dysfunction in Parkinson's Disease

Mitochondrial Dysfunction in Neurodegeneration

mitochondrial-dynamics-dysfunction-parkinsons

Mitochondria

Mitophagy Pathway in Neurodegeneration

Mitochondrial Dysfunction in Progressive Supranuclear Palsy

cGAS-STING Signaling in Parkinson's Disease

Mitochondria in Neurodegeneration

mitochondrial-dynamics

Schwann Cells in Peripheral Neuropathy

endoplasmic-reticulum-stress

Mitochondrial Dynamics Dysfunction Hypothesis in Parkinson's Disease

Energy Metabolism in Neurodegeneration

Glycogen Synthase Kinase-3β (GSK-3β)

Mitochondria-Lysosome Contact Site Dysfunction in Parkinson's Disease

Exercise-BDNF-Mitochondrial Resilience Hypothesis

PINK1-Parkin Mitophagy Pathway in Parkinson's Disease

Charcot-Marie-Tooth Disease