Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about MT3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
MT3 is a gene implicated in neurodegeneration research. Key relationships include: interacts with, regulates, implicated in. Associated with Als, Alzheimer, Inflammation. Connected to 14 entities in the SciDEX knowledge graph.
| Gene Symbol | MT3 |
| Full Name | Metallothionein-3 |
| Aliases | GIF, neuronal growth inhibitory factor |
| Chromosome | 16q13 |
| Protein Type | Metallothionein |
| Function | MT3 (Metallothionein 3), also known as Growth-Inhibitory Factor (GIF), is a metallothionein protein primarily expressed in the central nervous system. |
| Primary Expression | the central nervous system |
| Amino Acids | 68 aa |
| Pathways | Metal Ion Homeostasis |
| UniProt ID | P07151 |
| NCBI Gene ID | 4502 |
| Ensembl ID | ENSG00000125148 |
| OMIM | 157170 |
| GeneCards | MT3 |
| Human Protein Atlas | MT3 |
| Associated Diseases | neurodegeneration |
| Interactions | P53, INFLAMMATION, NEURODEGENERATION |
| KG Connections | 14 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
MT3["<b>MT3</b>"]
Tumor{"Tumor"}
MT3 -->|"interacts_with"| Tumor
Parkinson{"Parkinson"}
MT3 -->|"regulates"| Parkinson
Als{"Als"}
MT3 -->|"interacts_with"| Als
Inflammation{"Inflammation"}
MT3 -->|"interacts_with"| Inflammation
Alzheimer{"Alzheimer"}
MT3 -->|"regulates"| Alzheimer
Neurodegeneration{"Neurodegeneration"}
MT3 -->|"interacts_with"| Neurodegeneration
NEURODEGENERATION(["NEURODEGENERATION"])
NEURODEGENERATION -->|"interacts_with"| MT3
style MT3 fill:#1a3a4a,stroke:#ce93d8,stroke-width:3px,color:#ce93d8| Target | Relation | Type | Str |
|---|---|---|---|
| Metal Ion Homeostasis | regulates | process | 0.90 |
| Tumor | interacts_with | disease | 0.65 |
| Parkinson | regulates | disease | 0.65 |
| Als | interacts_with | disease | 0.65 |
| Inflammation | interacts_with | disease | 0.65 |
| Alzheimer | regulates | disease | 0.65 |
| Neurodegeneration | interacts_with | disease | 0.65 |
| PARKINSON | regulates | gene | 0.60 |
| ALZHEIMER | regulates | gene | 0.60 |
| P53 | interacts_with | gene | 0.60 |
| INFLAMMATION | interacts_with | gene | 0.60 |
| NEURODEGENERATIVE DISORDERS | regulates | gene | 0.60 |
| Cell Cycle | interacts_with | pathway | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| NEURODEGENERATION | interacts_with | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity