Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about NCOA1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
NCOA1 is a gene implicated in neurodegeneration research. Key relationships include: therapeutic target, inhibits, implicated in. Associated with Cancer, Ms. Connected to 10 entities in the SciDEX knowledge graph.
| Gene Symbol | NCOA1 |
| Full Name | Nuclear Receptor Coactivator 1 |
| Chromosome | 2p23.3 |
| Protein Type | Receptor |
| Function | is a member of the p160 family of nuclear receptor coactivators[@ncoa2000]. |
| Primary Expression | the brain and has been implicated in various neurological processes including neuroprotection, synaptic plasticity, and neurodegenerative disease path |
| Molecular Weight | ~164 kDa |
| Amino Acids | 1459 aa |
| UniProt ID | Q15788 |
| NCBI Gene ID | 8644 |
| Ensembl ID | ENSG00000084676 |
| OMIM | 602071 |
| GeneCards | NCOA1 |
| Human Protein Atlas | NCOA1 |
| Protein Length | 1459 amino acids |
| Associated Diseases | neurodegeneration |
| Interactions | HIF1A, RELA, EGFR |
| KG Connections | 9 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
NCOA1["<b>NCOA1</b>"]
Ms{"Ms"}
NCOA1 -->|"therapeutic target"| Ms
Cancer{"Cancer"}
NCOA1 -->|"therapeutic target"| Cancer
HIF1A["HIF1A"]
NCOA1 -->|"inhibits"| HIF1A
HSP90AA1["HSP90AA1"]
NCOA1 -->|"therapeutic target"| HSP90AA1
CANCER["CANCER"]
NCOA1 -->|"therapeutic target"| CANCER
ESR1["ESR1"]
NCOA1 -->|"therapeutic target"| ESR1
neurodegeneration["neurodegeneration"]
NCOA1 -->|"implicated in"| neurodegeneration
FOS["FOS"]
FOS -->|"therapeutic target"| NCOA1
RELA["RELA"]
RELA -->|"inhibits"| NCOA1
EGFR["EGFR"]
EGFR -->|"inhibits"| NCOA1
style NCOA1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity