gene

RELA

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about RELA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

756Connections

16Hypotheses

3Analyses

50Outgoing

50Incoming

0Experiments

3Debates

Summary

RELA is a gene implicated in neurodegeneration research. Key relationships include: activates, regulates, therapeutic target. Associated with Aging, Als, Alzheimer. Connected to 379 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	NF
Full Name	κB p65 Protein
Aliases	RELA
Function	Nf Κb P105 Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
GeneCards	NF
Human Protein Atlas	NF
Associated Diseases	Aging, Als, Cancer, Glioblastoma, Hepatitis, Inflammation
Known Drugs/Compounds	RESVERATROL
Interactions	AKT, AKT1, ALZHEIMER, ALZHEIMER DISEASE, AMYLOID, AND
KG Connections	755 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    RELA["RELA"]
    RELA -->|"activates"| Cancer["Cancer"]
    RELA -->|"activates"| Inflammation["Inflammation"]
    RELA -->|"activates"| Aging["Aging"]
    RELA -->|"activates"| Ms["Ms"]
    RELA -->|"activates"| Carcinoma["Carcinoma"]
    RELA -->|"activates"| Tumor["Tumor"]
    RELA -->|"interacts"| Als["Als"]
    NRF2["NRF2"] -->|"inhibits"| RELA
    P38["P38"] -->|"activates"| RELA
    MAP1LC3["MAP1LC3"] -->|"activates"| RELA
    IL1B["IL1B"] -->|"activates"| RELA
    PRDX1["PRDX1"] -->|"activates"| RELA
    TRAF6["TRAF6"] -->|"activates"| RELA
    CHUK["CHUK"] -->|"activates"| RELA
    PRDX6["PRDX6"] -->|"activates"| RELA

Outgoing (476)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:RELA	data_in	dataset_row	0.00
RELA	encodes	protein	0.00
ds-83b31ef18d49	provides_data_for	dataset	1.00
Senescence-Associated Secretory Phenotype	promotes	phenotype	0.95
Inflammation	activates	disease	0.95
YY1	activates	gene	0.90
Nuclear Translocation	involved_in	process	0.90
MIR125B	upregulates	gene	0.90
CANCER	activates	gene	0.90
Tumor	activates	disease	0.85
Cancer	activates	disease	0.85
MIR125B	regulates	biomarker	0.85
Osteoclast Differentiation	regulates	process	0.85
Als	interacts_with	disease	0.85
Als	expressed_in	disease	0.85
Als	activates	disease	0.85
MIR9	regulates	biomarker	0.80
Nf-Κb	interacts_with	pathway	0.80
Als	therapeutic_target	disease	0.75
Cancer	therapeutic_target	disease	0.75
Carcinoma	activates	disease	0.75
Inflammation	regulates	disease	0.75
Nf-Κb	expressed_in	pathway	0.70
neuroinflammation	regulates	phenotype	0.70
ADORA2A	indirectly_modulates	gene	0.70
CANCER	therapeutic_target	gene	0.70
Mapk	therapeutic_target	pathway	0.70
Nf-Κb	activates	pathway	0.70
C1QB	regulates	gene	0.70
C1QC	regulates	gene	0.70
Nf-Κb	therapeutic_target	pathway	0.70
C1QA	regulates	gene	0.70
Nf-Κb	regulates	pathway	0.70
NEURONS	protects_against	cell_type	0.70
ISCHEMIA	causes	disease	0.70
ISCHEMIA	modifies	disease	0.70
Apoptosis	activates	pathway	0.70
Parkinson	therapeutic_target	disease	0.65
Inflammation	therapeutic_target	disease	0.65
Tumor	therapeutic_target	disease	0.65
Breast Cancer	therapeutic_target	disease	0.65
Ms	regulates	disease	0.65
Als	associated_with	disease	0.65
ALS	interacts_with	disease	0.65
Cancer	expressed_in	disease	0.65
Carcinoma	expressed_in	disease	0.65
NOS2	interacts_with	gene	0.65
Fibrosis	therapeutic_target	disease	0.65
ISCHEMIA	phosphorylates	disease	0.65
Alzheimer	activates	disease	0.65

Incoming (280)

Source	Relation	Type	Str
RELA	encodes	gene	0.00
benchmark_ot_ad_answer_key:RELA	data_in	dataset_row	0.00
ds-83b31ef18d49	data_in	dataset	1.00
IKBKG	phosphorylates	gene	0.90
NFKBIA	regulates	protein	0.90
Lapiferin	downregulates	compound	0.90
Riboflavin	suppresses	drug	0.87
IKBA	inhibits	protein	0.85
Scutellarein	downregulates	compound	0.85
STAT3	interacts_with	gene	0.70
NF-ΚB	therapeutic_target	gene	0.70
INFLAMMATION	activates	gene	0.70
CYTOKINES	activates	gene	0.70
INFLAMMATION	regulates	gene	0.70
NRF2	inhibits	protein	0.70
ALS	treats	disease	0.70
TNF	therapeutic_target	gene	0.70
TP53	therapeutic_target	gene	0.70
AKT1	therapeutic_target	gene	0.70
NF-ΚB	interacts_with	gene	0.70
RESVERATROL	treats	drug	0.70
ROS	inhibits	phenotype	0.65
MITOPHAGY	inhibits	phenotype	0.65
MYC	regulates	gene	0.65
ESR1	therapeutic_target	gene	0.60
TAB1	expressed_in	gene	0.60
IRAK4	expressed_in	gene	0.60
TAK1	activates	gene	0.60
BCL2	therapeutic_target	gene	0.60
AKT1	activates	gene	0.60
IFNG	therapeutic_target	gene	0.60
JUN	therapeutic_target	gene	0.60
MAPK3	therapeutic_target	gene	0.60
STAT3	therapeutic_target	gene	0.60
AXIN1	activates	gene	0.60
RHEB	activates	gene	0.60
HNF4A	activates	gene	0.60
JUN	activates	gene	0.60
FOS	therapeutic_target	gene	0.60
CTNNB1	therapeutic_target	gene	0.60
PIK3CA	interacts_with	gene	0.60
MMP9	interacts_with	gene	0.60
PPARA	interacts_with	gene	0.60
IGF1R	interacts_with	gene	0.60
NEAT1	interacts_with	gene	0.60
YWHAZ	expressed_in	gene	0.60
HSP90AB1	expressed_in	gene	0.60
CAV1	expressed_in	gene	0.60
NORAD	interacts_with	gene	0.60
ANTIOXIDANT GENES	regulates	gene	0.60

Targeting Hypotheses (16)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Gamma entrainment corrects AD-related clock gene dysregulati	0.676	alzheimers	Gamma entrainment therapy to restore hip
FABP5/7 Inhibition (H2): Lipid Relay Interruption	0.670	neurodegeneration	Does restoring neuronal AMPK activity re
microglial priming as a partially upstream causal node rathe	0.604	neurodegeneration	Microglial Priming as Upstream Causal No
H4: Age-Related Hsp70 Chaperone Decline Blocks Granule Rever	0.577	neurodegeneration	How do pathological stress granules tran
CYP46A1 Gene Therapy for Age-Related TREM2-Mediated Microgli	0.555	neurodegeneration	TREM2 in Alzheimer's Disease: Mechanisms

H4: Polycomb Repression Relaxes at Neurodevelopment Genes	0.530	neurodegeneration	Investigate mechanisms of epigenetic rep
Microglial Reactivation Status Modifies Amyloid Clearance an	0.524	neurodegeneration	-
HDAC1/2 Complex Restoration Corrects Age-Related Histone Hyp	0.520	neurodegeneration	Investigate mechanisms of epigenetic rep
Lamin B1 Restoration Prevents Age-Related Nuclear Lamina Com	0.510	neurodegeneration	Investigate mechanisms of epigenetic rep
DNA Hypomethylation at P2RY12 Promoter Correlates with Disea	0.440	neurodegeneration	What determines P2RY12 receptor expressi
CD38 Inhibition to Prevent NAD+ Depletion and Restore Cellul	0.380	metabolomics	Metabolomic signatures of neurodegenerat
Age-related neuroinflammation mimics early Alzheimer's disea	0.362	alzheimers	Allen Mouse Brain Aging Atlas: cross-age
age-linked CpG drift is the actionable driver in: Are age-re	0.344	neurodegeneration	Are age-related DNA methylation changes
ATAC-seq accessibility separates causal from compensatory st	0.327	neurodegeneration	Are age-related DNA methylation changes
protective chromatin remodeling defines the therapeutic wind	0.326	neurodegeneration	Are age-related DNA methylation changes
Peripheral-to-Central Inflammatory Relay Disruption	0.000	-	Blood-brain barrier tight junction disru

Mentioning Analyses (3)

Scientific analyses that reference this entity

How does parthenolide specifically modulate ADORA2A signaling to produce antidep

neuropharmacology | 2026-04-25 | 4 hypotheses Top: 0.659

How does sevoflurane-induced NF-κB activation specifically trigger complement ca

neuroinflammation | 2026-04-08 | 5 hypotheses Top: 0.658

Senescent cell clearance as neurodegeneration therapy

neurodegeneration | 2026-04-02 | 7 hypotheses

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (6)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
Enhancing TREM2 expression activates microglia and modestly mitigates tau pathol [PMID:40122810]	["Chen Kai", "Li Fuyao", "Zhang Shuwen",	Journal of neuroinflammation	2025
The cholesterol 24-hydroxylase CYP46A1 promotes α-synuclein pathology in Parkins [PMID:39964974]	Dai L, Wang J, Meng L, Zhang X, Xiao T,	PLoS biology	2025
Enhancing TREM2 expression activates microglia and modestly mitigates tau pathol [PMID:40122810]	["Chen Kai", "Li Fuyao", "Zhang Shuwen",	Journal of neuroinflammation	2025
Neurodegeneration and Inflammation-An Interesting Interplay in Parkinson's Disea [PMID:33182554]	Marogianni C, Sokratous M, Dardiotis E,	International journal of molec	2020
Neurodegeneration and Inflammation-An Interesting Interplay in Parkinson's Disea [PMID:33182554]	Marogianni C, Sokratous M, Dardiotis E,	International journal of molec	2020
Multiple Sclerosis Pathology. [PMID:29358320]	Lassmann H	Cold Spring Harbor perspective	2018

Debates (3)

Multi-agent debates referencing this entity

How does parthenolide specifically modulate ADORA2A signaling to produce antidep

closed · Rounds: 4 · Score: 0.66 · 2026-04-25

While the study demonstrates both NF-κB pathway activation and increased C1qa ex

closed · Rounds: 4 · Score: 0.74 · 2026-04-21

Senescent cell clearance as neurodegeneration therapy

closed · Rounds: 4 · Score: 0.95 · 2026-04-02

Related Research

Hypotheses and analyses mentioning RELA in their description or question text

RELA

Understanding Entity Pages

Summary

Wiki Pages (3)

NF-κB p65 Protein

RELA (p65) Protein

RELA (NF-κB p65)

Pathway Diagram

Outgoing (476)

Incoming (280)

Targeting Hypotheses (16)

Mentioning Analyses (3)

How does parthenolide specifically modulate ADORA2A signaling to produce antidep

How does sevoflurane-induced NF-κB activation specifically trigger complement ca

Senescent cell clearance as neurodegeneration therapy

Experiments (0)

Related Papers (6)

Debates (3)

How does parthenolide specifically modulate ADORA2A signaling to produce antidep

While the study demonstrates both NF-κB pathway activation and increased C1qa ex

Senescent cell clearance as neurodegeneration therapy

Related Research

H4: Polycomb Repression Relaxes at Neurodevelopment Genes

HDAC1/2 Complex Restoration Corrects Age-Related Histone Hypoacetylation

Lamin B1 Restoration Prevents Age-Related Nuclear Lamina Compromise

DNA Hypomethylation at P2RY12 Promoter Correlates with Disease Progression

CD38 Inhibition to Prevent NAD+ Depletion and Restore Cellular Bioenergetics in

Age-related neuroinflammation mimics early Alzheimer's disease pathology

age-linked CpG drift is the actionable driver in: Are age-related DNA methylatio

ATAC-seq accessibility separates causal from compensatory states in: Are age-rel

protective chromatin remodeling defines the therapeutic window for: Are age-rela

Peripheral-to-Central Inflammatory Relay Disruption