gene

RELA

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about RELA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

757Connections

1Hypotheses

29Analyses

50Outgoing

50Incoming

Summary

RELA is a gene implicated in neurodegeneration research. Key relationships include: activates, regulates, therapeutic target. Associated with Aging, Als, Alzheimer. Connected to 379 entities in the SciDEX knowledge graph.

View on Wiki →

🧬 Gene Info

Gene Symbol	NF
Full Name	RELA (NF-κB p65)
Aliases	NF-κB p65
Protein Family	NF-κB transcription factors
Protein Type	Transcription Factor
Function	RELA (p65) is a key transcription factor subunit of NF-κB.
Molecular Weight	65 kDa
Pathways	NF-κB, NF-κB signaling
UniProt ID	[P06579](https://www.uniprot.org/uniprot/P06579)
NCBI Gene ID	Search NCBI
GeneCards	NF
Human Protein Atlas	NF
Associated Diseases	Aging, Als, Cancer, Glioblastoma, Hepatitis, ISCHEMIA
Known Drugs/Compounds	RESVERATROL
Interactions	TAK1, IKBKB, IL6, LC3, AKT, AKT1
KG Connections	757 knowledge graph edges
Databases	GeneCards HPA STRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    RELA["RELA"]
    RELA -->|"activates"| Cancer["Cancer"]
    RELA -->|"activates"| Inflammation["Inflammation"]
    RELA -->|"activates"| Aging["Aging"]
    RELA -->|"activates"| Ms["Ms"]
    RELA -->|"activates"| Carcinoma["Carcinoma"]
    RELA -->|"activates"| Tumor["Tumor"]
    RELA -->|"interacts"| Als["Als"]
    NRF2["NRF2"] -->|"inhibits"| RELA
    P38["P38"] -->|"activates"| RELA
    MAP1LC3["MAP1LC3"] -->|"activates"| RELA
    IL1B["IL1B"] -->|"activates"| RELA
    PRDX1["PRDX1"] -->|"activates"| RELA
    TRAF6["TRAF6"] -->|"activates"| RELA
    CHUK["CHUK"] -->|"activates"| RELA
    PRDX6["PRDX6"] -->|"activates"| RELA

Outgoing (473)

Target	Relation	Type	Str
ds-83b31ef18d49	provides_data_for	dataset	1.00
Senescence-Associated Secretory Phenotype	promotes	phenotype	0.95
Inflammation	activates	disease	0.95
Nuclear Translocation	involved_in	process	0.90
YY1	activates	gene	0.90
MIR125B	upregulates	gene	0.90
CANCER	activates	gene	0.90
Osteoclast Differentiation	regulates	process	0.85
MIR125B	regulates	biomarker	0.85
Cancer	activates	disease	0.85
Tumor	activates	disease	0.85
Als	interacts_with	disease	0.85
Als	expressed_in	disease	0.85
Als	activates	disease	0.85
MIR9	regulates	biomarker	0.80
Nf-Κb	interacts_with	pathway	0.80
Carcinoma	activates	disease	0.75
Cancer	therapeutic_target	disease	0.75
Als	therapeutic_target	disease	0.75
Inflammation	regulates	disease	0.75
Apoptosis	activates	pathway	0.70
Nf-Κb	expressed_in	pathway	0.70
CANCER	therapeutic_target	gene	0.70
Mapk	therapeutic_target	pathway	0.70
Nf-Κb	regulates	pathway	0.70
Nf-Κb	activates	pathway	0.70
Nf-Κb	therapeutic_target	pathway	0.70
ISCHEMIA	modifies	disease	0.70
ISCHEMIA	causes	disease	0.70
NEURONS	protects_against	cell_type	0.70
IL6	interacts_with	gene	0.65
SIRT1	regulates	gene	0.65
NOS2	interacts_with	gene	0.65
Aging	activates	disease	0.65
Ms	activates	disease	0.65
Ms	interacts_with	disease	0.65
Atherosclerosis	interacts_with	disease	0.65
Alzheimer	expressed_in	disease	0.65
Dementia	expressed_in	disease	0.65
Fibrosis	therapeutic_target	disease	0.65
Ms	therapeutic_target	disease	0.65
Ms	associated_with	disease	0.65
Als	regulates	disease	0.65
Aging	associated_with	disease	0.65
Cancer	associated_with	disease	0.65
Diabetes	therapeutic_target	disease	0.65
Obesity	therapeutic_target	disease	0.65
Stroke	therapeutic_target	disease	0.65
Hypertension	therapeutic_target	disease	0.65
Ischemia	therapeutic_target	disease	0.65

Incoming (284)

Source	Relation	Type	Str
ds-83b31ef18d49	data_in	dataset	1.00
IKBKG	phosphorylates	gene	0.90
NFKBIA	regulates	protein	0.90
Lapiferin	downregulates	compound	0.90
Riboflavin	suppresses	drug	0.87
Scutellarein	downregulates	compound	0.85
IKBA	inhibits	protein	0.85
NRF2	inhibits	protein	0.70
TP53	therapeutic_target	gene	0.70
TNF	therapeutic_target	gene	0.70
AKT1	therapeutic_target	gene	0.70
STAT3	interacts_with	gene	0.70
NF-ΚB	therapeutic_target	gene	0.70
CYTOKINES	activates	gene	0.70
INFLAMMATION	activates	gene	0.70
NF-ΚB	interacts_with	gene	0.70
INFLAMMATION	regulates	gene	0.70
ALS	treats	disease	0.70
RESVERATROL	treats	drug	0.70
MYC	regulates	gene	0.65
MITOPHAGY	inhibits	phenotype	0.65
ROS	inhibits	phenotype	0.65
P38	activates	gene	0.60
IL1B	activates	gene	0.60
PRDX1	activates	gene	0.60
TRAF6	activates	gene	0.60
CHUK	activates	gene	0.60
PRDX6	activates	gene	0.60
MAPK14	activates	gene	0.60
BECN1	activates	gene	0.60
TNF	activates	gene	0.60
ECSIT	activates	gene	0.60
MAP3K7	activates	gene	0.60
TLR4	activates	gene	0.60
PANX1	regulates	gene	0.60
S100B	regulates	gene	0.60
RELB	regulates	gene	0.60
P2RY1	regulates	gene	0.60
CASP3	regulates	gene	0.60
SOCS3	regulates	gene	0.60
TRPA1	regulates	gene	0.60
CXCL2	regulates	gene	0.60
SNAP25	regulates	gene	0.60
P2RX7	regulates	gene	0.60
SYT2	regulates	gene	0.60
TNF	regulates	gene	0.60
SOD2	regulates	gene	0.60
NOS2	regulates	gene	0.60
P2RX3	regulates	gene	0.60
PI3K	therapeutic_target	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
CYP46A1 Gene Therapy for Age-Related TREM2-Mediated Microgli	0.569	neurodegeneration	Lipid raft composition changes in synapt

Mentioning Analyses (29)

Scientific analyses that reference this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

RELA

Understanding Entity Pages

Summary

Wiki Pages (21)

RELA (NF-κB p65)

NF-kB Signaling Pathway in Neurodegeneration

NF-κB Signaling Pathway in Neurodegeneration

nfkb-neurodegeneration

NF-κB Signaling in Neurodegeneration

GSK3B Gene - Glycogen Synthase Kinase 3 Beta

Neuroinflammation in Neurodegeneration

GSK3B (Glycogen Synthase Kinase 3 Beta)

Sirtuin Signaling Pathway

LTBR Gene

S100 Protein Signaling Pathway in Neurodegeneration

NF-κB Pathway Inhibition for Neurodegeneration

c-Rel Protein

Circadian Rhythm Dysfunction in Alzheimer's Disease

NF-κB Signaling in Neuroinflammation

NF-kB Pathway Inhibition Therapy for Neurodegeneration

ikkgamma

Circular RNA Dysfunction in Neurodegeneration

GSK3-beta Signaling Pathway

ABIN1 (TNIP1) Gene

nf-kb

Pathway Diagram

Outgoing (473)

Incoming (284)

Targeting Hypotheses (1)

Mentioning Analyses (29)

What molecular mechanisms link elevated sphingomyelin synthase activity to incre

What molecular mechanisms cause iPLA2β deficiency to specifically damage mitocho

What molecular mechanisms mediate HDAC9's effects on Aβ deposition and synaptic

What molecular mechanisms mediate HDAC9's effects on Aβ deposition and synaptic

Why does the V1613M variant reduce amyloid pathology when ABCA7 loss-of-function

What mechanisms explain how IDH1/IDH2 mutations with reduced enzymatic activity

What is the temporal sequence of sleep disruption versus amyloid-beta accumulati

What is the optimal ketone dosing threshold to avoid metabolic steal syndrome wh

Do PINK1/PARKIN pathway enhancements rescue excitatory neuron vulnerability or c

Which cell-type vulnerability signatures from SEA-AD single-cell data represent

Do PINK1/PARKIN pathway enhancements rescue excitatory neuron vulnerability or e

What are the specific molecular mechanisms linking ADCY8 to spatial memory conso

Does TFEB dysfunction causally drive neurodegeneration or represent compensatory

What are the minimal structural requirements for HSP70/HSP90 inhibitors to achie

Why do clinical manifestations overlap despite distinct underlying etiologies in

How does SPI1 transcriptionally regulate C1QA and C1QC expression in atheroscler

Can circadian interventions reverse microglial priming independent of sleep disr

What are the specific pathophysiological mechanisms underlying uncommon immune-m

What are the specific molecular mechanisms by which C1Q components drive atheros

What is the optimal therapeutic window timing for autophagy enhancement versus s

Do APOE4-driven senescent astrocytes cause neurodegeneration or represent a prot

Epigenetic reprogramming in aging neurons

Quantitative proteomics of the aging synapse in early Alzheimer disease

Does TFEB dysfunction cause neurodegeneration or represent a compensatory respon

CRISPR-based therapeutic approaches for neurodegenerative diseases

CRISPR-based therapeutic approaches for neurodegenerative diseases

Is disrupted sleep a cause or consequence of neurodegeneration? Analyze the bidi

Is disrupted sleep a cause or consequence of neurodegeneration? Analyze the bidi

Senolytic therapy for age-related neurodegeneration

Related Papers (0)