gene 944 words KG: NCOA1 2026-03-24
kind:genesection:genesstate:published
Contents

NCOA1 Gene

🧬 Gene Info
Gene SymbolNCOA1
Full NameNuclear Receptor Coactivator 1
Chromosome2p23.3
Protein TypeReceptor
Functionis a member of the p160 family of nuclear receptor coactivators[@ncoa2000].
Primary Expressionthe brain and has been implicated in various neurological processes including neuroprotection, synaptic plasticity, and neurodegenerative disease path
Molecular Weight~164 kDa
Amino Acids1459 aa
UniProt IDQ15788
NCBI Gene ID8644
Ensembl IDENSG00000084676
OMIM602071
GeneCardsNCOA1
Human Protein AtlasNCOA1
Protein Length1459 amino acids
Associated Diseasesneurodegeneration
InteractionsHIF1A, RELA, EGFR
KG Connections9 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (15)

Digital Twin-Guided Metabolic Reprogramming
Score: 0.61
Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.51
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.68
CYP46A1 Overexpression Gene Therapy
Score: 0.63
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.59

Related Analyses (3)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (7)

RELA (NF-κB p65)
gene · KG edge: inhibits
HSP90AA1 Gene
gene · KG edge: therapeutic_target
HIF1A Gene - Hypoxia Inducible Factor 1 Subunit Alpha
gene · KG edge: inhibits
FOS Gene
gene · KG edge: therapeutic_target
ESR1 — Estrogen Receptor Alpha
gene · KG edge: therapeutic_target

Knowledge Graph (9 edges)

NCOA1 inhibits HIF1A
NCOA1 therapeutic_target HSP90AA1
NCOA1 therapeutic_target ESR1
NCOA1 therapeutic_target CANCER
NCOA1 therapeutic_target Ms
NCOA1 therapeutic_target Cancer
FOS therapeutic_target NCOA1
RELA inhibits NCOA1
EGFR inhibits NCOA1