protein

EAAT2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about EAAT2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

99Connections

0Hypotheses

2Analyses

50Outgoing

22Incoming

0Experiments

2Debates

Summary

Page for EAAT2 Protein

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🔬 Protein Info

Gene Symbol	EAAT2
Function	EAAT2 (also known as GLT-1 or SLC1A2) is a 574-amino acid transmembrane protein that functions as the primary glutamate transporter in the brain.
Subcellular Localization	Plasma membrane, astrocytic processes ensheathing synapses ; Protein Family : Ex
Molecular Weight	65 kDa
Amino Acids	574 aa
Pathways	neurotrophin signaling, glutamate signaling, circadian regulation, Tau Phosphorylation
GeneCards	EAAT2
Human Protein Atlas	EAAT2
Associated Diseases	ALS, Alzheimer, epilepsy, neurodegeneration, Parkinson
Known Drugs/Compounds	memantine, rapamycin
Interactions	ALZHEIMER, AQP4, BDNF, BMAL1, CREB, GABA
KG Connections	99 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (6)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    EAAT2["EAAT2"]
    ALZHEIMER["ALZHEIMER"]
    EAAT2 -->|"activates"| ALZHEIMER
    Alzheimer_S_Disease["Alzheimer'S Disease"]
    EAAT2 -->|"activates"| Alzheimer_S_Disease
    disease["disease"]
    EAAT2 -->|"activates"| disease
    ALZHEIMER_S["ALZHEIMER'S"]
    EAAT2 -->|"activates"| ALZHEIMER_S
    GLUTAMATE["GLUTAMATE"]
    EAAT2 -->|"activates"| GLUTAMATE
    EXCITOTOXICITY["EXCITOTOXICITY"]
    EAAT2 -->|"activates"| EXCITOTOXICITY
    ALZHEIMER["ALZHEIMER"]
    EAAT2 -->|"inhibits"| ALZHEIMER
    Alzheimer_S_Disease["Alzheimer'S Disease"]
    EAAT2 -->|"inhibits"| Alzheimer_S_Disease
    disease["disease"]
    EAAT2 -->|"inhibits"| disease
    ALZHEIMER_S["ALZHEIMER'S"]
    EAAT2 -->|"inhibits"| ALZHEIMER_S
    GLUTAMATE["GLUTAMATE"]
    EAAT2 -->|"inhibits"| GLUTAMATE
    EXCITOTOXICITY["EXCITOTOXICITY"]
    EAAT2 -->|"inhibits"| EXCITOTOXICITY
    Tau_Phosphorylation["Tau Phosphorylation"]
    EAAT2 -->|"activates"| Tau_Phosphorylation
    Astrocytes["Astrocytes"]
    EAAT2 -->|"activates"| Astrocytes
    Astrocyte["Astrocyte"]
    EAAT2 -->|"activates"| Astrocyte
    Reactive_Oxygen_Species["Reactive Oxygen Species"]
    EAAT2 -->|"activates"| Reactive_Oxygen_Species
    PARKINSON["PARKINSON"]
    EAAT2 -->|"activates"| PARKINSON
    Parkinson_s_Disease["Parkinson's Disease"]
    EAAT2 -->|"activates"| Parkinson_s_Disease
    PARKINSON_S["PARKINSON'S"]
    EAAT2 -->|"activates"| PARKINSON_S
    NF__B["NF-kappaB"]
    EAAT2 -->|"activates"| NF__B
    NEUROTOXICITY["NEUROTOXICITY"]
    EAAT2 -->|"activates"| NEUROTOXICITY
    B_CELLS["B CELLS"]
    EAAT2 -->|"activates"| B_CELLS
    NF__B_P65["NF-KappaB P65"]
    EAAT2 -->|"activates"| NF__B_P65
    oxidative_stress["oxidative stress"]
    EAAT2 -->|"activates"| oxidative_stress
    TNF__["TNF-alpha"]
    EAAT2 -->|"activates"| TNF__
    CELL_DEATH["CELL DEATH"]
    EAAT2 -->|"regulates"| CELL_DEATH
    GLUTAMATE["GLUTAMATE"]
    EAAT2 -->|"regulates"| GLUTAMATE
    EXCITOTOXICITY["EXCITOTOXICITY"]
    EAAT2 -->|"regulates"| EXCITOTOXICITY
    CENTRAL_NERVOUS_SYSTEM["CENTRAL NERVOUS SYSTEM"]
    EAAT2 -->|"regulates"| CENTRAL_NERVOUS_SYSTEM
    Cognitive_Impairment["Cognitive Impairment"]
    EAAT2 -->|"inhibits"| Cognitive_Impairment

Outgoing (77)

Target	Relation	Type	Str
ASTROCYTES	expressed_in	cell_type	0.95
Glutamate	transports	compound	0.95
Glutamate transport	catalyzes	process	0.90
astrocytes	expressed_in	cell_type	0.75
Glutamate Homeostasis	regulates	phenotype	0.70
Alzheimer's disease	interacts_with	disease	0.70
neurons	expressed_in	cell_type	0.70
glutamate toxicity	prevents	mechanism	0.70
GFAP	biomarker_for	gene	0.60
HLA	biomarker_for	gene	0.60
epilepsy	causes	disease	0.60
GABA	associated_with	gene	0.60
NMDAR	associated_with	gene	0.60
NMDAR	activates	gene	0.60
ubiquitin-proteasome	participates_in	pathway	0.60
Alzheimer's disease	activates	disease	0.60
Parkinson's disease	activates	disease	0.60
YY1	activates	gene	0.60
NF-kB signaling	participates_in	pathway	0.60
IKK	activates	gene	0.60
TNF	activates	gene	0.60
oxidative stress response	participates_in	pathway	0.60
GFAP	activates	gene	0.60
PKA	activates	gene	0.60
NMDA	inhibits	gene	0.60
Parkinson	associated_with	disease	0.60
Alzheimer	associated_with	disease	0.60
ALS	associated_with	disease	0.60
epilepsy	associated_with	disease	0.60
neurodegeneration	associated_with	disease	0.60
VGLUT1	inhibits	gene	0.55
glutamate signaling	participates_in	pathway	0.55
microglia	expressed_in	cell_type	0.55
TNF	inhibits	gene	0.55
RNA	inhibits	gene	0.55
GDNF	activates	gene	0.55
neurotrophin signaling	participates_in	pathway	0.55
circadian regulation	participates_in	pathway	0.55
IKK	co_expressed_with	protein	0.50
TNF	co_expressed_with	gene	0.50
oxidative stress	activates	phenotype	0.50
TNF-α	activates	concept	0.50
CELL DEATH	regulates	concept	0.50
GLUTAMATE	regulates	concept	0.50
EXCITOTOXICITY	regulates	concept	0.50
ALZHEIMER	activates	gene	0.50
Cognitive Impairment	inhibits	phenotype	0.50
Astrocytes	regulates	cell_type	0.50
INSULIN	inhibits	concept	0.50
RAPAMYCIN	inhibits	concept	0.50

Incoming (22)

Source	Relation	Type	Str
PSEN1	interacts_with	gene	0.95
Insulin	upregulates	protein	0.90
ALDH1L1	biomarker_for	gene	0.60
CD68	biomarker_for	gene	0.60
memantine	targets	drug	0.60
rapamycin	targets	drug	0.60
AQP4	inhibits	gene	0.55
APOE4	expressed_in	gene	0.55
BMAL1	activates	gene	0.55
AQP4	activates	gene	0.55
BDNF	activates	gene	0.55
CREB	activates	gene	0.55
NMDA	inhibits	protein	0.50
manganism	activates	disease	0.50
EPILEPSY	causes	gene	0.50
NMDA	activates	protein	0.50
GFAP	activates	gene	0.50
mTOR	expressed_in	entity	0.50
SLC1A2	activates	gene	0.50
Neurodegeneration	inhibits	disease	0.50
GABA	inhibits	gene	0.50
AKT	associated_with	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (2)

Scientific analyses that reference this entity

Do these mechanistic hypotheses from the SEA-AD Atlas bundle explain layer-speci

neurodegeneration | 2026-04-10 | 0 hypotheses

Cell type vulnerability debate in Alzheimer's disease (SEA-AD v4)

neurodegeneration | 2026-04-02 | 7 hypotheses Top: 0.710

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (2)

Multi-agent debates referencing this entity

Which cell types show the greatest vulnerability in Alzheimer's disease accordin

closed · Rounds: 4 · Score: 0.75 · 2026-04-22

Do these mechanistic hypotheses from the SEA-AD Atlas bundle explain layer-speci

closed · Rounds: 4 · Score: 0.30 · 2026-04-21

Related Research

Hypotheses and analyses mentioning EAAT2 in their description or question text

No additional research found

EAAT2

Understanding Entity Pages

Summary

Wiki Pages (6)

EAAT2 Glutamate Transporter Rescue Therapy

Astrocyte Glutamate-Buffer Rescue: EAAT2 Transcription Reboot Therapy

Astrocyte Glutamate-Buffer Rescue with EAAT2 Transcription Reboot

SLC1A2 — Solute Carrier Family 1 Member 2 (EAAT2)

EAAT2 Protein

SLC1A2 Protein — EAAT2/GLT-1

Pathway Diagram

Outgoing (77)

Incoming (22)

Targeting Hypotheses (0)

Mentioning Analyses (2)

Do these mechanistic hypotheses from the SEA-AD Atlas bundle explain layer-speci

Cell type vulnerability debate in Alzheimer's disease (SEA-AD v4)

Experiments (0)

Related Papers (0)

Debates (2)

Which cell types show the greatest vulnerability in Alzheimer's disease accordin

Do these mechanistic hypotheses from the SEA-AD Atlas bundle explain layer-speci

Related Research