protein

NQO1 PROTEIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NQO1 PROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

9Connections

0Hypotheses

0Analyses

5Outgoing

4Incoming

Summary

Page for NQO1 Protein — NAD(P)H Quinone Dehydrogenase 1

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🔬 Protein Info

Gene Symbol	NQO1
Function	is a 274-amino acid flavoprotein that serves as a critical detoxification enzyme in cellular redox homeostasis.
Molecular Weight	31 kDa
Pathways	cGAS-Type I Interferon Signaling, oxidative stress response, Apoptosis, Oxidative Stress, Akt
GeneCards	NQO1
Human Protein Atlas	NQO1
Associated Diseases	Glioblastoma, Inflammation, Senescence
Interactions	IL-1Β, NLRP3, CASPASE-1, HO-1, KEAP1, NQO1
KG Connections	9 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (8)

Knowledge base pages for this entity

Pathway Diagram

flowchart TD
    NQO1_PROTEIN(["NQO1 PROTEIN"])
    IL_1_(["IL-1Beta"])
    NLRP3(["NLRP3"])
    CASPASE_1(["CASPASE-1"])
    HO_1(["HO-1"])
    TNF__("TNF-alpha")
    KEAP1(["KEAP1"])
    NQO1(["NQO1"])
    NRF2(["NRF2"])
    IL_6(["IL-6"])

    NQO1_PROTEIN -->|"activates"| IL_1_
    NQO1_PROTEIN -->|"activates"| NLRP3
    NQO1_PROTEIN -->|"activates"| CASPASE_1
    NQO1_PROTEIN -->|"activates"| HO_1
    NQO1_PROTEIN -->|"activates"| TNF__
    KEAP1 -->|"activates"| NQO1_PROTEIN
    NQO1 -->|"activates"| NQO1_PROTEIN
    NRF2 -->|"activates"| NQO1_PROTEIN
    IL_6 -->|"activates"| NQO1_PROTEIN

    style NQO1_PROTEIN fill:#1a237e,stroke:#4fc3f7,stroke-width:3px,color:#fff

Outgoing (5)

Target	Relation	Type	Str
IL-1Β	activates	protein	0.50
NLRP3	activates	protein	0.50
CASPASE-1	activates	protein	0.50
HO-1	activates	protein	0.50
TNF-α	activates	concept	0.50

Incoming (4)

Source	Relation	Type	Str
KEAP1	activates	gene	0.50
NQO1	activates	gene	0.50
NRF2	activates	gene	0.50
IL-6	activates	protein	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

NQO1 PROTEIN

Understanding Entity Pages

Summary

Wiki Pages (8)

NQO1 Protein (NAD(P)H Quinone Dehydrogenase 1)

Nuclear Factor Erythroid 2-Related Factor 2 (Nrf2)

Parkinson's Disease NRF2-Keap1 Pathway Therapy Companies

Nrf2 Signaling in Parkinson's Disease

NFE2L1 — Nuclear Factor Erythroid 2-Like 1

NFE2L3 Protein