gene

NQO1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NQO1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

280Connections

0Hypotheses

3Analyses

50Outgoing

50Incoming

0Experiments

4Debates

Summary

NQO1 is a gene implicated in neurodegeneration research. Key relationships include: activates, therapeutic target, regulates. Associated with Als, Alzheimer, Anxiety. Connected to 113 entities in the SciDEX knowledge graph.

View on Wiki →

No AI portrait yet

🧬 Gene Info

Gene Symbol	NQO1
Full Name	NAD(P)H Quinone Dehydrogenase 1
Aliases	NAD(P
Chromosome	16q22.1
Function	NQO1 uses NAD(P)H as an electron donor to reduce quinones, preventing the formation of toxic semiquinone radicals.
Subcellular Localization	** \| Cytoplasm, also nucleus (minor) \|
Molecular Weight	31 kDa
Amino Acids	274 aa
Pathways	Apoptosis, Ferroptosis
UniProt ID	P15559
NCBI Gene ID	1728
Ensembl ID	ENSG00000100119
OMIM	125860
GeneCards	NQO1
Human Protein Atlas	NQO1
Associated Diseases	Inflammation, Senescence
Interactions	AKT, ALZHEIMER, ALZHEIMER'S DISEASE, AND, ANTIOXIDANT GENES, APOPTOSIS
KG Connections	280 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: NQO1 — AlphaFold P15559 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    NQO1["NQO1"] -->|"biomarker for"| Inflammation["Inflammation"]
    NQO1["NQO1"] -->|"activates"| Inflammation_1["Inflammation"]
    NQO1["NQO1"] -->|"activates"| Obesity["Obesity"]
    NQO1["NQO1"] -->|"associated"| Inflammation_2["Inflammation"]
    NQO1["NQO1"] -.->|"inhibits"| Stroke["Stroke"]
    NQO1["NQO1"] -.->|"inhibits"| Ms["Ms"]
    NRF2["NRF2"] -->|"activates"| NQO1["NQO1"]
    NRF2_3["NRF2"] -->|"regulates"| NQO1["NQO1"]
    GCLC["GCLC"] -->|"regulates"| NQO1["NQO1"]
    GCLM["GCLM"] -->|"regulates"| NQO1["NQO1"]
    style NQO1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (179)

Target	Relation	Type	Str
Oxidative Stress Resistance	mediates	mechanism	0.95
cGAS-Type I Interferon Signaling	inhibits	pathway	0.90
Glioblastoma Stem Cells	associated_with	cell_type	0.90
ROS Levels	downregulates	process	0.90
Lipid Peroxidation	inhibits	process	0.90
redox homeostasis	regulates	process	0.90
NRF2	activates	gene	0.90
oxidative stress response	participates_in	pathway	0.80
Glioblastoma	biomarker_for	disease	0.80
HO-1	activates	gene	0.80
NRF2	regulates	gene	0.70
Oxidative Stress	activates	pathway	0.70
AKT	activates	gene	0.70
PI3K	activates	gene	0.70
OXIDATIVE STRESS	activates	gene	0.70
APOPTOSIS	activates	gene	0.70
Apoptosis	activates	pathway	0.70
KEAP1	activates	gene	0.70
CAT	activates	gene	0.70
amyloid clearance	regulates	mechanism	0.70
Oxidative Stress	associated_with	pathway	0.70
Inflammation	biomarker_for	disease	0.65
Inflammation	associated_with	disease	0.65
Addiction	therapeutic_target	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Anxiety	therapeutic_target	disease	0.65
Tumor	regulates	disease	0.65
Cancer	regulates	disease	0.65
Ovarian Cancer	regulates	disease	0.65
Stroke	therapeutic_target	disease	0.65
Epilepsy	therapeutic_target	disease	0.65
ALS	regulates	disease	0.65
Inflammation	regulates	disease	0.65
Aging	regulates	disease	0.65
Neuroinflammation	regulates	disease	0.65
Ms	activates	disease	0.65
Cancer	activates	disease	0.65
Depression	therapeutic_target	disease	0.65
Parkinson	therapeutic_target	disease	0.65
Ms	therapeutic_target	disease	0.65
Parkinson	activates	disease	0.65
Als	activates	disease	0.65
Lymphoma	activates	disease	0.65
Als	inhibits	disease	0.65
Cancer	inhibits	disease	0.65
Neurodegeneration	inhibits	disease	0.65
Inflammation	activates	disease	0.65
Obesity	activates	disease	0.65
Ms	inhibits	disease	0.65
Inflammation	inhibits	disease	0.65

Incoming (101)

Source	Relation	Type	Str
IPA	upregulates	compound	0.95
Mn And Fe	upregulates	compound	0.95
NFE2L2	upregulates	gene	0.85
NRF2	regulates	protein	0.72
NFE2L2	regulates	gene	0.70
FSP1	regulates	gene	0.60
GPX4	regulates	gene	0.60
HO1	activates	gene	0.60
DMT1	regulates	gene	0.60
OXIDATIVE STRESS	biomarker_for	gene	0.60
BAX	activates	gene	0.60
INFLAMMATION	biomarker_for	gene	0.60
NAD	regulates	gene	0.60
NAD	expressed_in	gene	0.60
NADPH	activates	gene	0.60
GENES	biomarker_for	gene	0.60
AKT	therapeutic_target	gene	0.60
TNF	therapeutic_target	gene	0.60
FSP1	inhibits	gene	0.60
CAT	causes	gene	0.60
GCLM	causes	gene	0.60
INFLAMMATION	inhibits	gene	0.60
ALZHEIMER	therapeutic_target	gene	0.60
STROKE	therapeutic_target	gene	0.60
IL-6	therapeutic_target	gene	0.60
DEPRESSION	therapeutic_target	gene	0.60
PARKINSON	therapeutic_target	gene	0.60
EPILEPSY	therapeutic_target	gene	0.60
ANXIETY	therapeutic_target	gene	0.60
VEGF	associated_with	gene	0.60
COX2	inhibits	gene	0.60
PI3K	therapeutic_target	gene	0.60
GCLM	regulates	gene	0.60
HMOX1	regulates	gene	0.60
LOX	activates	gene	0.60
HO1	associated_with	gene	0.60
NRF2	therapeutic_target	gene	0.60
PKC	therapeutic_target	gene	0.60
BDNF	associated_with	gene	0.60
STAT6	associated_with	gene	0.60
REELIN	associated_with	gene	0.60
NOX2	regulates	gene	0.60
AND	inhibits	gene	0.60
GCLC	regulates	gene	0.60
GR	inhibits	gene	0.60
CAT	activates	gene	0.60
PARKINSON	activates	gene	0.60
NEUROINFLAMMATION	activates	gene	0.60
TNF-Α	activates	gene	0.60
PARKINSON'S DISEASE	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (3)

Scientific analyses that reference this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (4)

Multi-agent debates referencing this entity

Related Research

Hypotheses and analyses mentioning NQO1 in their description or question text

No additional research found

NQO1

Understanding Entity Pages

Summary

Wiki Pages (3)

NQO1 Protein (NAD(P)H Quinone Dehydrogenase 1)

NQO1 — NAD(P)H Quinone Dehydrogenase 1

NQO1 Protein — NAD(P)H Quinone Dehydrogenase 1

Pathway Diagram

Outgoing (179)

Incoming (101)

Targeting Hypotheses (0)

Mentioning Analyses (3)

Test Preregistration Analysis

Gene Regulatory Network Inference in Alzheimer's Disease

Why do p300/CBP inhibitors reduce both AD incidence and clinically diagnosed TBI

Experiments (0)

Related Papers (0)

Debates (4)

Test question for preregistration

Which transcription factors drive the gene regulatory networks that distinguish

Is REST the master regulator of neuronal vulnerability in AD, or is it one of se

The observation that salsalate and diflunisal decrease both AD and TBI incidence

Related Research