Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about NON-ALCOHOLIC FATTY LIVER DISEASE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | NON-ALCOHOLIC FATTY LIVER DISEASE |
Knowledge base pages for this entity
graph TD
NON_ALCOHOLIC_FATTY_LIVER_DISE["NON-ALCOHOLIC FATTY LIVER DISEASE"]
NON_ALCOHOLIC_FATTY_LIVER_DISE -->|"causes"| Cirrhosis["Cirrhosis"]
High_Fat_Diet["High-Fat Diet"] -->|"causes"| NON_ALCOHOLIC_FATTY_LIVER_DISE
Autophagy["Autophagy"] -->|"involved_in"| NON_ALCOHOLIC_FATTY_LIVER_DISE
ATG["ATG"] -->|"involved_in"| NON_ALCOHOLIC_FATTY_LIVER_DISE
Autophagy_Dysfunction["Autophagy Dysfunction"] -->|"causes"| NON_ALCOHOLIC_FATTY_LIVER_DISE
NASH_Associated_Macrophages["NASH-Associated Macrophages"] -.biomarker for.-> NON_ALCOHOLIC_FATTY_LIVER_DISE
Metabolic_Syndrome["Metabolic Syndrome"] -->|"risk_factor_for"| NON_ALCOHOLIC_FATTY_LIVER_DISE
PPARG["PPARG"] -->|"involved_in"| NON_ALCOHOLIC_FATTY_LIVER_DISE| Target | Relation | Type | Str |
|---|---|---|---|
| Cirrhosis | causes | disease | 0.90 |
| Source | Relation | Type | Str |
|---|---|---|---|
| High-Fat Diet | causes | phenotype | 0.95 |
| Schisanhenol | treats | compound | 0.95 |
| Autophagy | involved_in | process | 0.95 |
| ATG | involved_in | gene | 0.95 |
| Autophagy Dysfunction | causes | process | 0.92 |
| NASH-Associated Macrophages | biomarker_for | cell_type | 0.90 |
| Autophagy Dysfunction | contributes_to | process | 0.90 |
| PPARG | involved_in | gene | 0.90 |
| Metabolic Syndrome | risk_factor_for | disease | 0.90 |
| Fgf21 | treats | drug | 0.85 |
| TREM2 | biomarker_for | protein | 0.85 |
| FGF21 | treats | protein | 0.85 |
| Iron Overload | contributes_to | phenotype | 0.85 |
| AKR1B10 | biomarker_for | protein | 0.85 |
| Insulin Resistance | contributes_to | phenotype | 0.85 |
| Fibrosis | contributes_to | process | 0.85 |
| Obesity | causes | disease | 0.85 |
| Diabetes | causes | disease | 0.85 |
| FOXO1 | regulates | protein | 0.82 |
| Jmjd3 | biomarker_for | biomarker | 0.80 |
| Atg7 | biomarker_for | biomarker | 0.80 |
| Endoplasmic Reticulum Stress | contributes_to | process | 0.80 |
| Oxidative Stress | contributes_to | process | 0.80 |
| TREM2 | implicated_in | gene | 0.70 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||