FGF21

Understanding Entity Pages

This page aggregates everything SciDEX knows about FGF21: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

FGF21 encodes a metabolic regulator of the FGF19 subfamily with emerging roles in neuroprotection, neuroinflammation, synaptic plasticity, and potential therapeutic applications in Alzheimer's and Parkinson's diseases.

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flowchart TD
    FGF21["FGF21<br/>Fibroblast Growth<br/>Factor 21"]
    FGFR1["FGFR1<br/>FGF Receptor 1"]
    JMJD3["JMJD3<br/>Histone Demethylase"]
    
    LipidCat["Lipid Catabolism<br/>Metabolic Process"]
    Inflammation["Inflammation<br/>Immune Response"]
    Neuroinflam["Neuroinflammation<br/>CNS Inflammation"]
    
    ALS["ALS<br/>Amyotrophic Lateral<br/>Sclerosis"]
    MS["Multiple Sclerosis<br/>Demyelinating<br/>Disease"]
    Stroke["Stroke<br/>Cerebrovascular<br/>Disease"]
    Ischemia["Ischemia<br/>Reduced Blood Flow"]
    
    Aging["Aging<br/>Cellular Senescence"]
    Senescence["Senescence<br/>Age-related<br/>Decline"]
    Fibrosis["Fibrosis<br/>Tissue Scarring"]
    
    Diabetes["Diabetes<br/>Metabolic<br/>Dysfunction"]
    FattyLiver["Fatty Liver<br/>Hepatic Steatosis"]
    
    FGF21 --|"interacts with"|--> FGFR1
    FGF21 --|"activates"|--> JMJD3
    FGF21 --|"promotes"|--> LipidCat
    
    FGF21 --|"biomarker for"|--> Inflammation
    FGF21 --|"biomarker for"|--> ALS
    FGF21 --|"biomarker for"|--> Aging
    FGF21 --|"biomarker for"|--> Senescence
    
    FGF21 --|"protects against"|--> Inflammation
    FGF21 --|"protects against"|--> Neuroinflam
    FGF21 --|"prevents"|--> FattyLiver
    
    FGF21 --|"therapeutic target"|--> Stroke
    FGF21 --|"therapeutic target"|--> MS
    FGF21 --|"therapeutic target"|--> Fibrosis
    
    Inflammation --|"leads to"|--> Neuroinflam
    Neuroinflam --|"contributes to"|--> ALS
    Neuroinflam --|"contributes to"|--> MS
    Ischemia --|"triggers"|--> Stroke
    
    style FGF21 fill:#006494
    style FGFR1 fill:#4a1a6b
    style JMJD3 fill:#4a1a6b
    style LipidCat fill:#1b5e20
    style Inflammation fill:#ef5350
    style Neuroinflam fill:#ef5350
    style ALS fill:#5d4400
    style MS fill:#5d4400
    style Stroke fill:#5d4400
    style Aging fill:#ef5350
    style Fibrosis fill:#ef5350