protein

OCLNPROTEIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about OCLNPROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

Occludin Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.

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🔬 Protein Info

Gene Symbol	OCLNPROTEIN
Full Name	Occludin Protein
Protein Family	Occludin family
Target Class	Structural Protein
Function	is an important component in the neurobiology of neurodegenerative diseases.
Mechanism of Action	Drugs targeting OCLN would stabilize or enhance tight junction protein interactions, reinforcing the structural integrity of the blood-brain barrier and reducing pathological barrier permeability. Therapeutic approaches would involve either direct protein stabilization or indirect modulation of occludin phosphorylation and trafficking to maintain barrier function.
Druggability	Low (0.32)
Clinical Stage	Approved
Molecular Weight	65.4 kDa
Amino Acids	148 aa
UniProt ID	Q16625
GeneCards	OCLNPROTEIN
Human Protein Atlas	OCLNPROTEIN
N-terminal cytoplasmic domain	Interacts with the actin cytoskeleton
C-terminal cytoplasmic tail	Binds to ZO-1 and other scaffolding proteins
Associated Diseases	Aging, Als, Alzheimer, anxiety
Known Drugs/Compounds	BENVITIMOD, BYF
Interactions	ABCB1, ABCG2, ACHE, ACTB, Actin, Adiponectin
SciDEX Target	View Target Profile (10 clinical trials)
KG Connections	842 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: OCLNPROTEIN — AlphaFold Q16625 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Occludin Protein

protein · 563 words

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Pathway Diagram

graph TD
    OCLNPROTEIN["OCLNPROTEIN"]
    neurodegeneration["neurodegeneration"]
    OCLNPROTEIN -->|"implicated_in"| neurodegeneration
    style OCLNPROTEIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning OCLNPROTEIN in their description or question text

No additional research found