gene

ABCG2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ABCG2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

230Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

ABCG2 is a gene implicated in neurodegeneration research. Key relationships include: associated with, activates, therapeutic target. Associated with Als, Alzheimer, Anxiety. Connected to 152 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	ABCG2
Full Name	ATP Binding Cassette Subfamily G Member 2
Chromosome	4q22.1
Protein Type	Transporter
Function	encodes a 72 kDa half-transporter that functions as a homodimer at the blood-brain barrier.
Molecular Weight	72 kDa
Exons	16
Pathways	Akt, Apoptosis, Autophagy, Blood-Brain Barrier, Cell Cycle
Ensembl ID	ENSG00000118777
GeneCards	ABCG2
Human Protein Atlas	ABCG2
Homodimeric architecture	Two ABCG2 monomers assemble via extensive TMD interactions to form a functional transporter with a central drug-binding cavity
Substrate specificity	Preferentially transports sulfated and glucuronidated conjugates, porphyrins, dietary flavonoids, urate, and various chemotherapeutic agents
Cooperative transport	Some substrates show positive cooperativity, with binding at one site enhancing transport at the other
Associated Diseases	Alzheimer, Alzheimer'S Disease, Anxiety, Dementia, Depression
Interactions	ZBP1, MFN2, GSDMD, RIPK1, RAB7A, CAT
KG Connections	230 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    ABCG2["ABCG2"] -->|"associated"| Alzheimer["Alzheimer"]
    ABCG2["ABCG2"] -->|"therapeutic target"| Dementia["Dementia"]
    ABCG2["ABCG2"] -->|"associated"| Depression["Depression"]
    ABCG2["ABCG2"] -->|"associated"| Anxiety["Anxiety"]
    ABCG2["ABCG2"] -->|"regulates"| Inflammation["Inflammation"]
    ABCG2["ABCG2"] -->|"therapeutic target"| Ms["Ms"]
    MAOB["MAOB"] -->|"associated"| ABCG2["ABCG2"]
    GABRA1["GABRA1"] -->|"associated"| ABCG2["ABCG2"]
    CHAT["CHAT"] -->|"associated"| ABCG2["ABCG2"]
    CYP2D6["CYP2D6"] -->|"associated"| ABCG2["ABCG2"]
    style ABCG2 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (155)

Target	Relation	Type	Str
Cancer	therapeutic_target	disease	0.75
Tumor	therapeutic_target	disease	0.75
Alzheimer	associated_with	disease	0.65
Dementia	therapeutic_target	disease	0.65
Depression	associated_with	disease	0.65
Anxiety	associated_with	disease	0.65
Inflammation	regulates	disease	0.65
Ms	therapeutic_target	disease	0.65
Diabetes	activates	disease	0.65
Ms	activates	disease	0.65
Dementia	associated_with	disease	0.65
Als	inhibits	disease	0.65
Cancer	inhibits	disease	0.65
Carcinoma	inhibits	disease	0.65
Glioblastoma	inhibits	disease	0.65
Als	activates	disease	0.65
Cancer	expressed_in	disease	0.65
Tumor	expressed_in	disease	0.65
Als	therapeutic_target	disease	0.65
Leukemia	expressed_in	disease	0.65
Cancer	regulates	disease	0.65
Als	regulates	disease	0.65
Carcinoma	expressed_in	disease	0.65
Dementia	interacts_with	disease	0.65
Cancer	activates	disease	0.65
Breast Cancer	therapeutic_target	disease	0.65
Inflammation	therapeutic_target	disease	0.65
Cardiovascular	therapeutic_target	disease	0.65
Tumor	inhibits	disease	0.65
Inflammation	inhibits	disease	0.65
Fibrosis	inhibits	disease	0.65
ADRB2	associated_with	gene	0.60
OPRM1	associated_with	gene	0.60
MAOB	associated_with	gene	0.60
CYP3A4	associated_with	gene	0.60
SLC6A3	associated_with	gene	0.60
GABRA1	associated_with	gene	0.60
APOE	associated_with	gene	0.60
CYP2D6	associated_with	gene	0.60
SLC6A4	associated_with	gene	0.60
SLC30A8	associated_with	gene	0.60
HTR2C	associated_with	gene	0.60
SLC6A2	associated_with	gene	0.60
NBEA	associated_with	gene	0.60
ZBP1	activates	gene	0.60
MFN2	activates	gene	0.60
GSDMD	activates	gene	0.60
RIPK1	activates	gene	0.60
RAB7A	inhibits	gene	0.60
CAT	activates	gene	0.60

Incoming (75)

Source	Relation	Type	Str
AMPK	activates	gene	0.70
MAOB	associated_with	gene	0.60
GABRA1	associated_with	gene	0.60
CHAT	associated_with	gene	0.60
CYP2D6	associated_with	gene	0.60
APOE	associated_with	gene	0.60
HMGCR	associated_with	gene	0.60
OPRM1	associated_with	gene	0.60
SLC30A8	associated_with	gene	0.60
COMT	associated_with	gene	0.60
NBEA	associated_with	gene	0.60
HTR2C	associated_with	gene	0.60
ADRA2A	associated_with	gene	0.60
BCHE	associated_with	gene	0.60
SLC6A2	associated_with	gene	0.60
SLC6A3	associated_with	gene	0.60
ABCB1	associated_with	gene	0.60
SLC6A4	associated_with	gene	0.60
GSTP1	associated_with	gene	0.60
CYP3A4	associated_with	gene	0.60
ADRB2	associated_with	gene	0.60
BAX	activates	gene	0.60
DRP1	activates	gene	0.60
FADD	activates	gene	0.60
NRF2	activates	gene	0.60
AKT	activates	gene	0.60
RAB7A	inhibits	gene	0.60
MFN2	activates	gene	0.60
GSDMD	activates	gene	0.60
CAT	activates	gene	0.60
ABCB1	interacts_with	gene	0.60
ABCB1	activates	gene	0.60
ABCB1	therapeutic_target	gene	0.60
ABCB1	expressed_in	gene	0.60
ABCB1	regulates	gene	0.60
ABCD3	expressed_in	gene	0.60
ABCA2	expressed_in	gene	0.60
ATP7A	expressed_in	gene	0.60
ABCG1	expressed_in	gene	0.60
SLC22A5	expressed_in	gene	0.60
CD44	therapeutic_target	gene	0.60
STAT3	therapeutic_target	gene	0.60
PI3K	therapeutic_target	gene	0.60
BID	therapeutic_target	gene	0.60
NRF2	therapeutic_target	gene	0.60
JNK	therapeutic_target	gene	0.60
AKT	inhibits	gene	0.60
STAT3	inhibits	gene	0.60
SMAD3	inhibits	gene	0.60
JAK2	inhibits	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

ABCG2

Understanding Entity Pages

Summary

Wiki Pages (21)

ABCG2 (BCRP) - ATP Binding Cassette Subfamily G Member 2

blood-brain-barrier

bbb-transport-mechanisms

Blood-Brain Barrier Breakdown in Neurodegeneration

blood-brain-barrier-endothelial-cells

Riluzole ALS Trials

Blood-Brain Barrier

ABCB1 — ATP-Binding Cassette Subfamily B Member 1

Blood-Brain Barrier Dysfunction: AD vs PD vs ALS Comparison

Blood-Brain Barrier

Blood-Brain Barrier Dysfunction and Therapeutic Strategies in CBS/PSP

arterial-endothelial-cells-brain

Brain Endothelial Cell Dysfunction in Neurodegeneration

AD BBB Modulation and Transport Technologies

ABCG4 Gene — ATP-Binding Cassette Subfamily G Member 4

ABCB1 (MDR1) - ATP Binding Cassette Subfamily B Member 1

NBEA — Neurobeachin

Technical Architecture

MFSD2A - Major Facilitator Superfamily Domain Containing 2A