Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about PABPN1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | PABPN1 |
| Chromosome | 14q11.2 |
| Function | It interacts with the cleavage and polyadenylation specificity factor (CPSF) complex to ensure proper 3'-end processing of pre-mRNA [1]. |
| Molecular Weight | 33 kDa |
| Amino Acids | 306 aa |
| Exons | 17 |
| Pathways | Proteasome, Ubiquitin-Proteasome |
| Ensembl ID | ENSG00000122591 |
| GeneCards | PABPN1 |
| Human Protein Atlas | PABPN1 |
| gene = PABPN1 [@polyalanine] | name = Poly(A) Binding Protein Nuclear 1 |
| ncbi_gene_id = 9063 | ensembl = ENSG00000122591 |
| Associated Diseases | Als |
| Interactions | HSP70, GAIN, TDP43 |
| KG Connections | 7 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
PABPN1["<b>PABPN1</b>"]
Ms{"Ms"}
PABPN1 -->|"activates"| Ms
Als{"Als"}
PABPN1 -->|"associated with"| Als
Ubiquitin_Proteasome(["Ubiquitin-Proteasome"])
PABPN1 -->|"activates"| Ubiquitin_Proteasome
Proteasome(["Proteasome"])
PABPN1 -->|"activates"| Proteasome
neurodegeneration["neurodegeneration"]
PABPN1 -->|"implicated in"| neurodegeneration
HSP70["HSP70"]
HSP70 -->|"activates"| PABPN1
GAIN["GAIN"]
GAIN -->|"activates"| PABPN1
style PABPN1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Ms | activates | disease | 0.65 |
| Als | associated_with | disease | 0.65 |
| Ubiquitin-Proteasome | activates | pathway | 0.60 |
| Proteasome | activates | pathway | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity