gene 2,110 words KG: PABPN1 2026-03-26
kind:genesection:genesstate:published
Contents

PABPN1

🧬 Gene Info
Gene SymbolPABPN1
Chromosome14q11.2
FunctionIt interacts with the cleavage and polyadenylation specificity factor (CPSF) complex to ensure proper 3'-end processing of pre-mRNA [1].
Molecular Weight33 kDa
Amino Acids306 aa
Exons17
PathwaysProteasome, Ubiquitin-Proteasome
Ensembl IDENSG00000122591
GeneCardsPABPN1
Human Protein AtlasPABPN1
gene = PABPN1 [@polyalanine]name = Poly(A) Binding Protein Nuclear 1
ncbi_gene_id = 9063ensembl = ENSG00000122591
Associated DiseasesAls
InteractionsHSP70, GAIN, TDP43
KG Connections7 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (7)

APOE-Dependent Autophagy Restoration
Score: 0.61
Senescence-Activated NAD+ Depletion Rescue
Score: 0.60
Senescence-Induced Lipid Peroxidation Spreading
Score: 0.53
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51
Senescence-Associated Myelin Lipid Remodeling
Score: 0.51

Related Analyses (2)

Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
Mechanistic role of APOE in neurodegeneration
neurodegeneration · archived

Related Experiments (5)

Mechanism: C9orf72 Hexanucleotide Repeat Expansion in ALS/FT
validation · proposed · Score: 0.40
cGAS-STING Pathway Validation Study in Parkinson's Disease
clinical · proposed · Score: 0.40
Microglial Aging and Immune Memory in Neurodegeneration — Tr
validation · proposed · Score: 0.40
Non-Motor Symptom Progression in Parkinson's Disease — Mecha
clinical · proposed · Score: 0.40
Synaptic Mitochondrial Resilience Enhancement for Parkinson'
validation · proposed · Score: 0.40

See Also (6)

Packard Center for ALS Research
institution · KG edge: associated_with
HSP70 Inducer Therapies for Neurodegeneration
idea · KG edge: activates
GAIN Gene - GABA-A Receptor Associated Protein Like 2
gene · KG edge: activates
Proteasome-Ubiquitin System Dysfunction Validation in P
experiment · KG edge: activates
Neurodegeneration
disease · KG edge: implicated_in

Knowledge Graph (7 edges)

PABPN1 activates Ms
PABPN1 associated_with Als
PABPN1 activates Ubiquitin-Proteasome
PABPN1 activates Proteasome
HSP70 activates PABPN1
GAIN activates PABPN1
TDP43 interacts_with PABPN1