Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about PBX3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
PBX3 is a TALE homeobox transcription factor that serves as a HOX cofactor in development, neurogenesis, and disease. PBX3 regulates gene expression in neuronal differentiation, and is implicated in Alzheimer's disease, ALS, and cancer metastasis.
| Gene Symbol | PBX3 |
| Full Name | Pre-B-cell Leukemia Homeobox 3 |
| Chromosome | 9q33.3 |
| Function | encodes a member of the TALE (Three Amino Acid Loop Extension) family of homeodomain transcription factors. |
| Molecular Weight | 47 kDa |
| Amino Acids | 430 aa |
| Pathways | Wnt, Notch, BMP effectors |
| UniProt ID | [P40417](https://www.uniprot.org/uniprot/P40417) |
| Ensembl ID | ENSG00000167081 |
| OMIM | 176076 |
| GeneCards | PBX3 |
| Human Protein Atlas | PBX3 |
| Homeodomain | The DNA-binding helix-turn-helix motif (residues 239-299) |
| TALE domain | The three-amino-acid loop extension between helices 1 and 2 of the homeodomain |
| Transactivation domain | Located in the N-terminal region |
| Associated Diseases | neurodegeneration |
| KG Connections | 7 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
PBX3["<b>PBX3</b>"]
Als{"Als"}
PBX3 -->|"expressed in"| Als
Ms{"Ms"}
PBX3 -->|"expressed in"| Ms
Glioblastoma{"Glioblastoma"}
PBX3 -->|"expressed in"| Glioblastoma
XBP1["XBP1"]
PBX3 -->|"expressed in"| XBP1
MICRORNAS["MICRORNAS"]
PBX3 -->|"expressed in"| MICRORNAS
PAX6["PAX6"]
PBX3 -->|"expressed in"| PAX6
ERN1["ERN1"]
PBX3 -->|"expressed in"| ERN1
neurodegeneration["neurodegeneration"]
PBX3 -->|"implicated in"| neurodegeneration
style PBX3 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||