gene

ERN1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ERN1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

986Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

Page for ERN1 — Endoplasmic Reticulum To Nucleus Signaling 1

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🧬 Gene Info

Gene Symbol	ERN1
Full Name	Endoplasmic Reticulum To Nucleus Signaling 1
Chromosome	6p24.3
Function	is an important component in the neurobiology of neurodegenerative diseases.
Amino Acids	1210 aa
Exons	54
Pathways	Akt, Apoptosis, Wnt
GeneCards	ERN1
Human Protein Atlas	ERN1
Associated Diseases	AD, ALI, ALS, Aging, Alzheimer
Known Drugs/Compounds	rapamycin
Interactions	PARKIN, FMR1, SNCA, FAM134B, LC3, EPAS1
KG Connections	986 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    ERN1["ERN1"] -->|"activates"| autophagy["autophagy"]
    ERN1["ERN1"] -->|"interacts with"| Dementia["Dementia"]
    ERN1["ERN1"] -->|"interacts with"| Cardiovascular["Cardiovascular"]
    ERN1["ERN1"] -->|"interacts with"| Als["Als"]
    ERN1["ERN1"] -->|"interacts with"| Alzheimer["Alzheimer"]
    ERN1["ERN1"] -->|"interacts with"| Parkinson["Parkinson"]
    ERS["ERS"] -->|"activates"| ERN1["ERN1"]
    CAT["CAT"] -->|"interacts with"| ERN1["ERN1"]
    OPTN["OPTN"] -->|"interacts with"| ERN1["ERN1"]
    DNM1L["DNM1L"] -->|"interacts with"| ERN1["ERN1"]
    style ERN1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (625)

Target	Relation	Type	Str
MTORC1	activates	protein	0.85
AUTOPHAGY	activates	pathway	0.84
LC3	regulates	gene	0.80
SQSTM1	regulates	gene	0.80
NLR	activates	gene	0.80
ROS	activates	gene	0.80
oxidative stress response	participates_in	pathway	0.80
autophagy pathway	participates_in	pathway	0.80
necroptosis	participates_in	pathway	0.80
MAPK signaling	participates_in	pathway	0.80
neural stem cells	activates	cell_type	0.80
NLR	regulates	gene	0.80
ROS	regulates	gene	0.80
neural stem cells	regulates	cell_type	0.80
Als	activates	disease	0.75
Inflammation	activates	disease	0.75
EIF2AK3	activates	gene	0.70
autophagy	activates	process	0.70
RB1	activates	gene	0.70
MTOR	activates	gene	0.70
PI3K	activates	gene	0.70
STAT3	activates	gene	0.70
FIP200	regulates	gene	0.70
JNK	regulates	gene	0.70
NBR1	regulates	gene	0.70
NLRP3	regulates	gene	0.70
OPTN	regulates	gene	0.70
RB1	regulates	gene	0.70
RB1CC1	regulates	gene	0.70
RIPK3	regulates	gene	0.70
STING1	regulates	gene	0.70
dendritic cells	activates	cell_type	0.70
MTOR	regulates	gene	0.70
PI3K	regulates	gene	0.70
STAT3	regulates	gene	0.70
dendritic cells	regulates	cell_type	0.70
Autophagy	activates	pathway	0.70
Er Stress	activates	pathway	0.70
apoptosis pathway	participates_in	pathway	0.70
NRBF2	activates	gene	0.70
PI3K-AKT-mTOR signaling	participates_in	pathway	0.70
stem cells	expressed_in	cell_type	0.70
JAK-STAT signaling	participates_in	pathway	0.70
MAPK	regulates	gene	0.70
unfolded protein response	participates_in	pathway	0.70
Arthritis	activates	disease	0.65
Dementia	interacts_with	disease	0.65
Cardiovascular	interacts_with	disease	0.65
Als	interacts_with	disease	0.65
Alzheimer	interacts_with	disease	0.65

Incoming (361)

Source	Relation	Type	Str
Endoplasmic Reticulum Stress	activates	process	0.90
EIF2AK3	regulates	gene	0.80
BECN1	regulates	gene	0.70
DDIT3	regulates	gene	0.70
ATG	activates	gene	0.70
DNA	activates	gene	0.70
rapamycin	targets	drug	0.70
ATG	regulates	gene	0.70
DNA	regulates	gene	0.70
ERS	activates	pathway	0.64
CAT	interacts_with	gene	0.60
OPTN	interacts_with	gene	0.60
DNM1L	interacts_with	gene	0.60
CANX	interacts_with	gene	0.60
LGALS3	interacts_with	gene	0.60
CALCOCO2	interacts_with	gene	0.60
G3BP1	interacts_with	gene	0.60
PEX3	interacts_with	gene	0.60
SQSTM1	interacts_with	gene	0.60
BCL2	interacts_with	gene	0.60
LMNA	interacts_with	gene	0.60
STING1	interacts_with	gene	0.60
TAX1BP1	interacts_with	gene	0.60
ATM	interacts_with	gene	0.60
SNCAIP	interacts_with	gene	0.60
RB1CC1	interacts_with	gene	0.60
MFN1	interacts_with	gene	0.60
CASP3	interacts_with	gene	0.60
AKT1	interacts_with	gene	0.60
CGAS	interacts_with	gene	0.60
CFTR	interacts_with	gene	0.60
RPS6KB1	interacts_with	gene	0.60
GRB2	interacts_with	gene	0.60
RHEB	interacts_with	gene	0.60
EIF2A	interacts_with	gene	0.60
LRRK2	interacts_with	gene	0.60
ATG16L1	interacts_with	gene	0.60
GABARAP	interacts_with	gene	0.60
HSPA5	activates	gene	0.60
DDIT3	interacts_with	gene	0.60
ABCD3	interacts_with	gene	0.60
MAP1LC3B	interacts_with	gene	0.60
AMBRA1	interacts_with	gene	0.60
CTSD	interacts_with	gene	0.60
MUL1	interacts_with	gene	0.60
PARKIN	interacts_with	gene	0.60
PRKN	interacts_with	gene	0.60
BNIP3L	interacts_with	gene	0.60
HIF1A	interacts_with	gene	0.60
GBA	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

ERN1

Understanding Entity Pages

Summary

Wiki Pages (21)

ERN1 — Endoplasmic Reticulum To Nucleus Signaling 1

Unfolded Protein Response (UPR)

endoplasmic-reticulum-stress

ER Stress and Unfolded Protein Response Pathway in Neurodegeneration

ER Stress and Unfolded Protein Response in Parkinson's Disease

ER Stress and Unfolded Protein Response in 4R-Tauopathies

SNCAIP Gene

SLC11A1

ER Stress and Unfolded Protein Response in Progressive Supranuclear Palsy

SEL1L - SEL1L E3 Ubiquitin Protein Ligase

PBX3 — Pre-B-cell Leukemia Homeobox 3

GADD34 Gene

CFTR Gene

ER Stress Pathway in Neurodegeneration

PEX3 Gene - Peroxisome Biogenesis Factor 3

atg16l1

ER Stress and Unfolded Protein Response in Neurodegeneration

ERN1/IRE1 Protein — ER Stress Sensor

Mitochondrial Dynamics Modulation Therapy