protein

PAX6

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PAX6: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

45Connections
0Hypotheses
0Analyses
28Outgoing
17Incoming
0Experiments

Summary

PAX6 is a protein involved in neurodegeneration research. Key relationships include: expressed in, regulates, inhibits. Associated with Als, Glioblastoma, Ms. Connected to 20 entities in the SciDEX knowledge graph.

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🔬 Protein Info
Gene SymbolPAX6
Full NamePaired Box 6
Chromosome11p13
Protein FamilyPaired Box (PAX) Transcription Factor Family
Protein TypeTranscription Factor
Functionis an important component in the neurobiology of neurodegenerative diseases.
Primary ExpressionDeveloping eye, Brain (forebrain, cortex, hippocampus), Olfactory epithelium, Pancreas
Subcellular LocalizationNucleus
Molecular Weight46.8 kDa
Amino Acids128 aa
UniProt IDP26367
NCBI Gene ID5080
Ensembl IDENSG00000061676
OMIM607108
GeneCardsPAX6
Human Protein AtlasPAX6
Associated DiseasesAlzheimer, neurodegeneration
InteractionsRb, DNA, GFAP
KG Connections45 knowledge graph edges
DatabasesGeneCardsHPASTRING
🔮 Predicted Structure: PAX6 — AlphaFold P26367 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

PAX6 — Paired Box 6

gene · 630 words

Alpha-Synuclein Propagation Mechanism

mechanism · 3235 words

Adult Neurogenesis in Neurodegenerative Disease

mechanism · 3124 words

Tanycytes

cell · 3047 words

Adult Neurogenesis in Neurodegeneration

mechanism · 3040 words

SMARCA2 (BRM)

gene · 2683 words

Pathway Diagram

graph TD
    PAX6["<b>PAX6</b>"]
    Ms{"Ms"}
    PAX6 -->|"regulates"| Ms
    Als{"Als"}
    PAX6 -->|"expressed in"| Als
    PAX6 -->|"expressed in"| Ms
    Glioblastoma{"Glioblastoma"}
    PAX6 -->|"expressed in"| Glioblastoma
    CDK6["CDK6"]
    PAX6 -->|"regulates"| CDK6
    Cell_Cycle(["Cell Cycle"])
    PAX6 -->|"inhibits"| Cell_Cycle
    ERN1["ERN1"]
    PAX6 -->|"expressed in"| ERN1
    FOXO1["FOXO1"]
    PAX6 -->|"expressed in"| FOXO1
    Neurogenesis(["Neurogenesis"])
    PAX6 -->|"expressed in"| Neurogenesis
    AND["AND"]
    PAX6 -->|"expressed in"| AND
    GENES["GENES"]
    PAX6 -->|"expressed in"| GENES
    DNA["DNA"]
    PAX6 -->|"inhibits"| DNA
    CDK6 -->|"regulates"| PAX6
    GENES -->|"expressed in"| PAX6
    DNA -->|"inhibits"| PAX6
    PBX3["PBX3"]
    PBX3 -->|"expressed in"| PAX6
    XBP1["XBP1"]
    XBP1 -->|"expressed in"| PAX6
    MICRORNAS["MICRORNAS"]
    MICRORNAS -->|"expressed in"| PAX6
    style PAX6 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (28)

TargetRelationTypeStr
ds-83b31ef18d49provides_data_fordataset1.00
corneal epithelial identitymediatesphenotype0.90
KRT12regulatesgene0.80
Msregulatesdisease0.65
Alsexpressed_indisease0.65

Incoming (17)

SourceRelationTypeStr
ds-83b31ef18d49data_indataset1.00
CD63regulatesgene0.85
CDK6expressed_inentity0.60
CDK6regulatesgene0.60
PBX3expressed_ingene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

ExperimentTypeDiseaseScoreFeasibilityModelStatusEst. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found