Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about PAX6: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
PAX6 is a protein involved in neurodegeneration research. Key relationships include: expressed in, regulates, inhibits. Associated with Als, Glioblastoma, Ms. Connected to 20 entities in the SciDEX knowledge graph.
| Gene Symbol | PAX6 |
| Full Name | Paired Box 6 |
| Chromosome | 11p13 |
| Protein Family | Paired Box (PAX) Transcription Factor Family |
| Protein Type | Transcription Factor |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Primary Expression | Developing eye, Brain (forebrain, cortex, hippocampus), Olfactory epithelium, Pancreas |
| Subcellular Localization | Nucleus |
| Molecular Weight | 46.8 kDa |
| Amino Acids | 128 aa |
| UniProt ID | P26367 |
| NCBI Gene ID | 5080 |
| Ensembl ID | ENSG00000061676 |
| OMIM | 607108 |
| GeneCards | PAX6 |
| Human Protein Atlas | PAX6 |
| Associated Diseases | Alzheimer, neurodegeneration |
| Interactions | Rb, DNA, GFAP |
| KG Connections | 45 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
PAX6["<b>PAX6</b>"]
Ms{"Ms"}
PAX6 -->|"regulates"| Ms
Als{"Als"}
PAX6 -->|"expressed in"| Als
PAX6 -->|"expressed in"| Ms
Glioblastoma{"Glioblastoma"}
PAX6 -->|"expressed in"| Glioblastoma
CDK6["CDK6"]
PAX6 -->|"regulates"| CDK6
Cell_Cycle(["Cell Cycle"])
PAX6 -->|"inhibits"| Cell_Cycle
ERN1["ERN1"]
PAX6 -->|"expressed in"| ERN1
FOXO1["FOXO1"]
PAX6 -->|"expressed in"| FOXO1
Neurogenesis(["Neurogenesis"])
PAX6 -->|"expressed in"| Neurogenesis
AND["AND"]
PAX6 -->|"expressed in"| AND
GENES["GENES"]
PAX6 -->|"expressed in"| GENES
DNA["DNA"]
PAX6 -->|"inhibits"| DNA
CDK6 -->|"regulates"| PAX6
GENES -->|"expressed in"| PAX6
DNA -->|"inhibits"| PAX6
PBX3["PBX3"]
PBX3 -->|"expressed in"| PAX6
XBP1["XBP1"]
XBP1 -->|"expressed in"| PAX6
MICRORNAS["MICRORNAS"]
MICRORNAS -->|"expressed in"| PAX6
style PAX6 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| ds-83b31ef18d49 | provides_data_for | dataset | 1.00 |
| corneal epithelial identity | mediates | phenotype | 0.90 |
| KRT12 | regulates | gene | 0.80 |
| Ms | regulates | disease | 0.65 |
| Als | expressed_in | disease | 0.65 |
| Ms | expressed_in | disease | 0.65 |
| Glioblastoma | expressed_in | disease | 0.65 |
| CDK6 | regulates | gene | 0.60 |
| ERN1 | expressed_in | gene | 0.60 |
| FOXO1 | expressed_in | gene | 0.60 |
| Rb | inhibits | protein | 0.60 |
| SMARCA4 | expressed_in | gene | 0.60 |
| SNAP25 | expressed_in | gene | 0.60 |
| Cell Cycle | inhibits | pathway | 0.60 |
| Neurogenesis | expressed_in | pathway | 0.60 |
| GENES | expressed_in | gene | 0.60 |
| DNA | inhibits | gene | 0.60 |
| AND | expressed_in | gene | 0.60 |
| neurodegeneration | associated_with | disease | 0.60 |
| Alzheimer | associated_with | disease | 0.60 |
| Progenitor Cell | expressed_in | cell_type | 0.55 |
| Cortex | expressed_in | brain_region | 0.55 |
| astrocytes | expressed_in | cell_type | 0.55 |
| neurons | expressed_in | cell_type | 0.55 |
| GENE EXPRESSION | regulates | concept | 0.50 |
| CELL CYCLE | activates | cell_type | 0.50 |
| CELL CYCLE | regulates | cell_type | 0.50 |
| benchmark_ot_ad_answer_key:PAX6 | data_in | dataset_row | 0.00 |
| Source | Relation | Type | Str |
|---|---|---|---|
| ds-83b31ef18d49 | data_in | dataset | 1.00 |
| CD63 | regulates | gene | 0.85 |
| CDK6 | expressed_in | entity | 0.60 |
| CDK6 | regulates | gene | 0.60 |
| PBX3 | expressed_in | gene | 0.60 |
| XBP1 | expressed_in | gene | 0.60 |
| GFAP | activates | gene | 0.60 |
| ADNP | expressed_in | gene | 0.60 |
| NLGN1 | expressed_in | gene | 0.60 |
| NLGN2 | expressed_in | gene | 0.60 |
| GENES | expressed_in | gene | 0.60 |
| DNA | inhibits | gene | 0.60 |
| MICRORNAS | expressed_in | gene | 0.60 |
| AND | expressed_in | gene | 0.60 |
| GFAP | co_expressed_with | gene | 0.50 |
| HDAC3 | co_expressed_with | gene | 0.50 |
| benchmark_ot_ad_answer_key:PAX6 | data_in | dataset_row | 0.00 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||