concept

PI3K/AKT SIGNALING PATHWAY

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PI3K/AKT SIGNALING PATHWAY: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

27Connections

0Hypotheses

1Analyses

17Outgoing

10Incoming

0Experiments

1Debates

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💡 Concept Info

Name	PI3K/AKT SIGNALING PATHWAY

Pathway Diagram

graph TD
    PI3K_AKT_SIGNALING_PATHWAY["PI3K/AKT SIGNALING PATHWAY"]
    PI3K_AKT_SIGNALING_PATHWAY -->|"regulates"| Apoptosis["Apoptosis"]
    PI3K_AKT_SIGNALING_PATHWAY -->|"inhibits"| amyloid_beta_neurotoxicity["amyloid-beta neurotoxicity"]
    PI3K_AKT_SIGNALING_PATHWAY -->|"involved_in"| NAFLD["NAFLD"]
    PI3K_AKT_SIGNALING_PATHWAY -->|"upstream_of"| BCL2["BCL2"]
    PI3K_AKT_SIGNALING_PATHWAY -.protects against.-> Alzheimer_s_disease["Alzheimer's disease"]
    PI3K_AKT_SIGNALING_PATHWAY -->|"regulates"| BAX["BAX"]
    PI3K_AKT_SIGNALING_PATHWAY -->|"inhibits"| oxidative_stress["oxidative stress"]
    PI3K_AKT_SIGNALING_PATHWAY -->|"inhibits"| endoplasmic_reticulum_stress["endoplasmic reticulum stress"]
    FDX1_Downregulation["FDX1 Downregulation"] -->|"activates"| PI3K_AKT_SIGNALING_PATHWAY
    NUP85["NUP85"] -->|"modulates"| PI3K_AKT_SIGNALING_PATHWAY
    LY290004["LY290004"] -->|"inhibits"| PI3K_AKT_SIGNALING_PATHWAY
    Osteoking["Osteoking"] -->|"activates"| PI3K_AKT_SIGNALING_PATHWAY
    LY294002["LY294002"] -->|"inhibits"| PI3K_AKT_SIGNALING_PATHWAY
    SQDS["SQDS"] -->|"inhibits"| PI3K_AKT_SIGNALING_PATHWAY
    GHYSJ["GHYSJ"] -->|"regulates"| PI3K_AKT_SIGNALING_PATHWAY

Outgoing (17)

Target	Relation	Type	Str
Cell Survival	activates	process	0.90
Cell Proliferation	activates	process	0.90
Apoptosis	regulates	process	0.90
apoptosis	regulates	process	0.90
amyloid-beta neurotoxicity	inhibits	process	0.80
BCL2	upstream_of	protein	0.80
NAFLD	involved_in	disease	0.80
Alzheimer's disease	protects_against	disease	0.78
BAX	regulates	protein	0.75
neuronal apoptosis	inhibits	process	0.70
inflammatory responses	inhibits	process	0.70
endoplasmic reticulum stress	inhibits	process	0.70
blood-brain barrier damage	protects_against	process	0.70
neurological function recovery	activates	process	0.70
cerebral ischemia-reperfusion injury	associated_with	disease	0.70
Alzheimer's disease	associated_with	disease	0.70
oxidative stress	inhibits	process	0.70

Incoming (10)

Source	Relation	Type	Str
FDX1 Downregulation	activates	mechanism	0.95
NUP85	modulates	protein	0.90
LY290004	inhibits	drug	0.90
PI3K	part_of	gene	0.90
GLP-1R agonists	activates	drug	0.90
natural products	targets	compound	0.85
LY294002	inhibits	compound	0.85
Osteoking	activates	drug	0.85
SQDS	inhibits	drug	0.82
GHYSJ	regulates	drug	0.70

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

What are the molecular mechanisms by which GLP-1RAs provide neuroprotective effe

neurodegeneration | 2026-04-14 | 0 hypotheses

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

The study demonstrates significant reduction in dementia risk (HR 0.63) with GLP

closed · Rounds: 4 · Score: 0.95 · 2026-04-16

Related Research

Hypotheses and analyses mentioning PI3K/AKT SIGNALING PATHWAY in their description or question text

No additional research found