Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about NEURONAL APOPTOSIS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | NEURONAL APOPTOSIS |
Knowledge base pages for this entity
graph TD
NEURONAL_APOPTOSIS["NEURONAL APOPTOSIS"]
ASK1["ASK1"] -->|"regulates"| NEURONAL_APOPTOSIS
Yiqi_Tongluo_Granule["Yiqi Tongluo Granule"] -->|"inhibits"| NEURONAL_APOPTOSIS
Cordycepin["Cordycepin"] -->|"inhibits"| NEURONAL_APOPTOSIS
Caspase_3["Caspase-3"] -->|"promotes"| NEURONAL_APOPTOSIS
DLK_Inhibition["DLK Inhibition"] -->|"inhibits"| NEURONAL_APOPTOSIS
Bergenin["Bergenin"] -->|"inhibits"| NEURONAL_APOPTOSIS
C3_C3aR_Pathway["C3/C3aR Pathway"] -->|"activates"| NEURONAL_APOPTOSIS| Target | Relation | Type | Str |
|---|---|---|---|
| Cognitive Deficits | causes | phenotype | 0.85 |
| Source | Relation | Type | Str |
|---|---|---|---|
| BDNF | protects_against | protein | 0.95 |
| ASK1 | regulates | protein | 0.95 |
| ASK1 | activates | protein | 0.95 |
| Yiqi Tongluo Granule | inhibits | drug | 0.90 |
| Cordycepin | inhibits | compound | 0.90 |
| Caspase-3 | promotes | protein | 0.90 |
| DLK Inhibition | inhibits | mechanism | 0.90 |
| Bergenin | inhibits | compound | 0.90 |
| ER Stress | contributes_to | process | 0.90 |
| XYS | inhibits | compound | 0.90 |
| Brain Cholesterol Accumulation | promotes | phenotype | 0.90 |
| TP53 | activates | protein | 0.90 |
| TAZ | suppresses | gene | 0.90 |
| Aucubin | suppresses | compound | 0.90 |
| Ceramide | promotes | compound | 0.90 |
| ACTG1 | promotes | protein | 0.90 |
| Unfolded Protein Response | mediates | pathway | 0.90 |
| mitochondrial dysfunction | promotes | phenotype | 0.90 |
| ZFP36 | inhibits | gene | 0.90 |
| PGAM5 | promotes | protein | 0.90 |
| C3/C3aR Pathway | activates | pathway | 0.88 |
| TLR2 | promotes | gene | 0.88 |
| Bergenin | protects_against | compound | 0.88 |
| mitochondrial dysfunction | drives | phenotype | 0.88 |
| Tong-Qiao-Huo-Xue Decoction | inhibits | drug | 0.87 |
| PI3K-Akt Signaling Pathway | modulates | pathway | 0.85 |
| Myriocin | regulates | drug | 0.85 |
| Chronic Demyelination | causes | disease | 0.85 |
| Complement C3/C3Ar Pathway | mediates | pathway | 0.85 |
| Ceramide | causes | compound | 0.85 |
| mitochondrial transfer | protects_against | process | 0.85 |
| L-glutamate | drives | compound | 0.85 |
| TLR2 | promotes | gene | 0.85 |
| Aucubin | suppresses | compound | 0.85 |
| ACTG1 | promotes | protein | 0.85 |
| ceramide | promotes | compound | 0.85 |
| AMYLOID BETA | causes | protein | 0.85 |
| WDR45 | causes | gene | 0.80 |
| Steroid Hormones | regulates | compound | 0.80 |
| Honokiol | inhibits | compound | 0.80 |
| TUFM | promotes | gene | 0.80 |
| CLU | modulates | protein | 0.80 |
| Bergenin | suppresses | compound | 0.80 |
| PROBDNF | promotes | protein | 0.80 |
| ERK | inhibits | protein | 0.80 |
| Pyroptosis | associated_with | process | 0.80 |
| Steroid Hormones | inhibits | compound | 0.72 |
| BDNF depletion | activates | process | 0.70 |
| hesperetin | protects_against | drug | 0.70 |
| caspase inhibition | protects_against | process | 0.70 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
neuroscience | 2026-04-04 | 0 hypotheses
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||