PI3K/AKT SIGNALING PATHWAY

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This page aggregates everything SciDEX knows about PI3K/AKT SIGNALING PATHWAY: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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graph TD
    PI3K_AKT_SIGNALING_PATHWAY["PI3K/AKT SIGNALING PATHWAY"]
    PI3K_AKT_SIGNALING_PATHWAY -->|"regulates"| Apoptosis["Apoptosis"]
    PI3K_AKT_SIGNALING_PATHWAY -->|"inhibits"| amyloid_beta_neurotoxicity["amyloid-beta neurotoxicity"]
    PI3K_AKT_SIGNALING_PATHWAY -->|"involved_in"| NAFLD["NAFLD"]
    PI3K_AKT_SIGNALING_PATHWAY -->|"upstream_of"| BCL2["BCL2"]
    PI3K_AKT_SIGNALING_PATHWAY -.protects against.-> Alzheimer_s_disease["Alzheimer's disease"]
    PI3K_AKT_SIGNALING_PATHWAY -->|"regulates"| BAX["BAX"]
    PI3K_AKT_SIGNALING_PATHWAY -->|"inhibits"| oxidative_stress["oxidative stress"]
    PI3K_AKT_SIGNALING_PATHWAY -->|"inhibits"| endoplasmic_reticulum_stress["endoplasmic reticulum stress"]
    FDX1_Downregulation["FDX1 Downregulation"] -->|"activates"| PI3K_AKT_SIGNALING_PATHWAY
    NUP85["NUP85"] -->|"modulates"| PI3K_AKT_SIGNALING_PATHWAY
    LY290004["LY290004"] -->|"inhibits"| PI3K_AKT_SIGNALING_PATHWAY
    Osteoking["Osteoking"] -->|"activates"| PI3K_AKT_SIGNALING_PATHWAY
    LY294002["LY294002"] -->|"inhibits"| PI3K_AKT_SIGNALING_PATHWAY
    SQDS["SQDS"] -->|"inhibits"| PI3K_AKT_SIGNALING_PATHWAY
    GHYSJ["GHYSJ"] -->|"regulates"| PI3K_AKT_SIGNALING_PATHWAY