concept

PI3K/AKT/MTOR SIGNALING PATHWAY

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PI3K/AKT/MTOR SIGNALING PATHWAY: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

31Connections
0Hypotheses
0Analyses
21Outgoing
10Incoming

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💡 Concept Info
NamePI3K/AKT/MTOR SIGNALING PATHWAY

Wiki Pages (17)

Knowledge base pages for this entity

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Pathway Diagram

graph TD
    PI3K_AKT_MTOR_SIGNALING_PATHWA["PI3K/AKT/MTOR SIGNALING PATHWAY"]
    PI3K_AKT_MTOR_SIGNALING_PATHWA -->|"contributes to"| Triple_Negative_Breast_Cancer_["Triple-Negative Breast Cancer Growth"]
    PI3K_AKT_MTOR_SIGNALING_PATHWA -->|"regulates"| Autophagy["Autophagy"]
    PI3K_AKT_MTOR_SIGNALING_PATHWA -->|"regulates"| Skeletal_Muscle_Aging["Skeletal Muscle Aging"]
    PI3K_AKT_MTOR_SIGNALING_PATHWA -->|"contributes to"| Angiogenesis["Angiogenesis"]
    PI3K_AKT_MTOR_SIGNALING_PATHWA -->|"contributes to"| Breast_Cancer_Proliferation["Breast Cancer Proliferation"]
    PI3K_AKT_MTOR_SIGNALING_PATHWA -->|"contributes to"| Breast_Cancer_Survival["Breast Cancer Survival"]
    PI3K_AKT_MTOR_SIGNALING_PATHWA -->|"inhibits"| Ferroptosis["Ferroptosis"]
    Polygonatum_Sibiricum_Polysacc["Polygonatum Sibiricum Polysaccharide"] -->|"activates"| PI3K_AKT_MTOR_SIGNALING_PATHWA
    Curcumin["Curcumin"] -->|"inhibits"| PI3K_AKT_MTOR_SIGNALING_PATHWA
    SPI1["SPI1"] -->|"activates"| PI3K_AKT_MTOR_SIGNALING_PATHWA
    LY294002["LY294002"] -->|"inhibits"| PI3K_AKT_MTOR_SIGNALING_PATHWA

Outgoing (21)

TargetRelationTypeStr
Triple-Negative Breast Cancer Growthcontributes_tophenotype0.95
Cancer Stem Cell Maintenanceinvolved_inprocess0.95
Cancer Stem Cell Proliferationactivatesprocess0.93
Skeletal Muscle Agingregulatesprocess0.90
Breast Cancer Proliferationcontributes_tophenotype0.90

Incoming (10)

SourceRelationTypeStr
Polygonatum Sibiricum Polysaccharideactivatescompound0.95
CircRNAmodulatesbiomarker0.95
Curcumininhibitscompound0.92
PI3K/Akt/mTOR Inhibitorsinhibitsdrug0.92
SPI1activatesgene0.90

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found