gene

SPI1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SPI1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

434Connections

7Hypotheses

3Analyses

50Outgoing

50Incoming

0Experiments

5Debates

Summary

SPI1/PU.1 - master microglial transcription factor, AD risk gene

View on Wiki →

No AI portrait yet

🧬 Gene Info

Gene Symbol	SPI1
Full Name	PU.1 Transcription Factor / Spi-1 Proto-Oncogene
Aliases	SPI1/PU.1
Chromosome	19q13.3
Protein Type	Transcription Factor
Function	encodes a transcription factor of the E26 transformation-specific (ETS) family.
Amino Acids	270 aa
Pathways	Amyloid, Mtor, Pi3K/Akt
UniProt ID	P17947
NCBI Gene ID	6678
Ensembl ID	ENSG00000135336
OMIM	165010
GeneCards	SPI1
Human Protein Atlas	SPI1
Associated Diseases	AD, ALI, Als, Alzheimer, Alzheimer's disease
Interactions	Actin, AKT, ALZHEIMER, ALZHEIMER DISEASE, ALZHEIMER'S DISEASE, AMYLOID
SciDEX Hypotheses	Neurovascular Unit SPI1 Signaling Hub Temporal SPI1 Inhibition for Neuroplasticity Recov SPI1-Mediated Metabolic Reprogramming in Neuroinfl (+3 more)
KG Connections	434 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: SPI1 — AlphaFold P17947 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

SPI1 Gene - PU.1

gene · 2569 words

→

PU.1 Protein (SPI1)

protein · 878 words

→

Pathway Diagram

graph TD
    SPI1["SPI1"]
    SPI1 -.biomarker for.-> Alzheimer_s_disease["Alzheimer's disease"]
    SPI1 -->|"target for"| Multiple_Sclerosis["Multiple Sclerosis"]
    SPI1 -->|"target for"| Alzheimer["Alzheimer"]
    SPI1 -->|"regulates"| Ms["Ms"]
    SPI1 -->|"target for"| Parkinson["Parkinson"]
    SPI1 -.biomarker for.-> Als["Als"]
    SPI1 -->|"activates"| Atherosclerosis["Atherosclerosis"]
    SPI1 -->|"activates"| Stroke["Stroke"]
    C1Q["C1Q"] -->|"expressed in"| SPI1
    C1QA["C1QA"] -->|"expressed in"| SPI1
    C1QC["C1QC"] -->|"expressed in"| SPI1
    CEBPA["CEBPA"] -->|"regulates"| SPI1
    HSPA1A["HSPA1A"] -->|"target for"| SPI1
    TFE3["TFE3"] -->|"regulates"| SPI1
    TP53["TP53"] -->|"regulates"| SPI1
    TRAF6["TRAF6"] -.biomarker for.-> SPI1
    P38["P38"] -.biomarker for.-> SPI1
    CD4["CD4"] -.biomarker for.-> SPI1

Outgoing (239)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:SPI1	data_in	dataset_row	0.00
ds-db4a006ea647	provides_data_for	dataset	1.00
ds-83b31ef18d49	provides_data_for	dataset	1.00
Microglial/Macrophage Inflammatory Response	regulates	process	0.95
PU.1	encodes	protein	0.90
PI3K/AKT/MTOR Signaling Pathway	activates	pathway	0.90
Microglia	expressed_in	cell_type	0.90
Neuroinflammation	regulates	process	0.85
Debris Clearance	associated_with	process	0.85
Phagocytosis	upregulates	process	0.85
C1QA	regulates	entity	0.85
C1QC	regulates	entity	0.85
APOE	regulates	gene	0.85
Autophagy	upregulates	process	0.85
HSPB1	regulates	gene	0.80
Remyelination	associated_with	process	0.80
Angiogenesis	associated_with	process	0.80
Glycolysis	upregulates	process	0.80
Complement Activation	associated_with	process	0.80
Als	activates	disease	0.75
microglia	expressed_in	cell_type	0.70
microglial activation states	regulates	phenotype	0.70
INPP5D expression	activates	gene	0.70
atherosclerosis inflammatory responses	regulates	disease	0.70
Inflammatory gene expression	regulates	phenotype	0.70
TYROBP transcription	regulates	phenotype	0.70
METABOLIC ENZYMES	regulates	gene	0.70
TYROBP	regulates	gene	0.70
C1Q	regulates	gene	0.70
macrophages	expressed_in	cell_type	0.70
atherosclerosis	associated_with	disease	0.70
microglial glycolytic metabolism	causes	phenotype	0.70
neurovascular_unit	orchestrates	cell_type	0.70
glycolytic_metabolism	regulates	pathway	0.70
Alzheimer's disease	associated_with	disease	0.70
microglia	regulates	cell_type	0.70
neuroinflammatory_memory	causes	phenotype	0.70
synaptic_plasticity	inhibits	phenotype	0.70
neuroinflammation	amplifies	phenotype	0.70
Alzheimer's disease	biomarker_for	disease	0.70
neuroinflammation	contributes_to	phenotype	0.70
microglial_activation	maintains	phenotype	0.70
chromatin_accessibility	modulates	mechanism	0.70
neuroinflammation	regulates	phenotype	0.70
Cancer	activates	disease	0.65
Inflammation	regulates	disease	0.65
Als	associated_with	disease	0.65
ALS	associated_with	disease	0.65
MACROPHAGES	treats	cell_type	0.65
Alzheimer	regulates	disease	0.65

Incoming (195)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:SPI1	data_in	dataset_row	0.00
ds-db4a006ea647	data_in	dataset	1.00
ds-83b31ef18d49	data_in	dataset	1.00
ALZHEIMER'S DISEASE	associated_with	disease	0.82
ALZHEIMER DISEASE	associated_with	gene	0.80
STAT3	activates	gene	0.70
APOE	activates	gene	0.70
chronic_vascular_inflammation	regulates	phenotype	0.70
C1Q	enhances	gene	0.70
APOE	associated_with	gene	0.66
AMYLOID	associated_with	protein	0.66
ALZHEIMER'S DISEASE	expressed_in	gene	0.60
PARKINSON	expressed_in	gene	0.60
PARKINSON'S DISEASE	expressed_in	gene	0.60
PILRA	associated_with	gene	0.60
COMPLEMENT	associated_with	gene	0.60
MIRNAS	biomarker_for	gene	0.60
C1QA	expressed_in	gene	0.60
GENES	regulates	gene	0.60
ALZHEIMER	expressed_in	gene	0.60
HSPB1	expressed_in	gene	0.60
CD33	regulates	gene	0.60
MS4A6A	regulates	gene	0.60
EGR1	encodes	gene	0.60
IL10	regulates	gene	0.60
SOCS3	encodes	gene	0.60
CEBPA	regulates	gene	0.60
TAU	activates	gene	0.60
RIN3	associated_with	gene	0.60
GAIN	activates	gene	0.60
HSPA1A	therapeutic_target	gene	0.60
C1Q	expressed_in	gene	0.60
STROKE	associated_with	gene	0.60
MMP12	activates	gene	0.60
TFE3	regulates	gene	0.60
CD33	activates	gene	0.60
NEURODEGENERATIVE DISEASES	expressed_in	gene	0.60
TYROBP	activates	gene	0.60
RHEB	encodes	gene	0.60
C1QC	expressed_in	gene	0.60
RELA	encodes	gene	0.60
HSPA1A	associated_with	gene	0.60
HNF4A	encodes	gene	0.60
GBM	associated_with	gene	0.60
AXIN1	encodes	gene	0.60
TREM2	activates	gene	0.60
LRP1	activates	gene	0.60
TMEM106B	associated_with	gene	0.60
TXNIP	activates	gene	0.60
SOCS3	activates	gene	0.60

Targeting Hypotheses (7)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
SPI1-Mediated Metabolic Reprogramming in Neuroinflammation	0.455	neuroinflammation	How does SPI1 transcriptionally regulate
Temporal SPI1 Inhibition for Neuroplasticity Recovery	0.455	neuroinflammation	How does SPI1 transcriptionally regulate
Microglial SPI1 Priming by Circulating C1Q	0.455	neuroinflammation	How does SPI1 transcriptionally regulate
Neurovascular Unit SPI1 Signaling Hub	0.455	neuroinflammation	How does SPI1 transcriptionally regulate
SPI1-C1Q Transcriptional Circuit Drives Cerebrovascular Neur	0.455	neuroinflammation	How does SPI1 transcriptionally regulate

Epigenetic SPI1 Reprogramming Therapy	0.455	neuroinflammation	How does SPI1 transcriptionally regulate
Dual SPI1 Inhibition for Atherosclerosis-Neurodegeneration A	0.455	neuroinflammation	How does SPI1 transcriptionally regulate