gene

SPI1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SPI1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

439Connections

0Hypotheses

1Analyses

50Outgoing

50Incoming

Summary

SPI1/PU.1 - master microglial transcription factor, AD risk gene

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🧬 Gene Info

Gene Symbol	SPI1
Full Name	PU.1 Transcription Factor / Spi-1 Proto-Oncogene
Aliases	SPI1/PU.1
Chromosome	19q13.3
Protein Type	Transcription Factor
Function	encodes a transcription factor of the E26 transformation-specific (ETS) family.
Amino Acids	270 aa
Pathways	Amyloid, Mtor, Pi3K/Akt
UniProt ID	P17947
NCBI Gene ID	6678
Ensembl ID	ENSG00000135336
OMIM	165010
GeneCards	SPI1
Human Protein Atlas	SPI1
Associated Diseases	AD, ALI, ALS, Alzheimer, Alzheimer's disease
Interactions	TAU, HNF4A, AXIN1, TBP, YWHAZ, SOCS3
KG Connections	439 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: SPI1 — AlphaFold P17947 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

GADD45G as Pathological Sensor: Orchestrating Reactive Gliosis in Neurodegeneration

mechanism · 2512 words

→

iPSC-Derived Microglia

cell · 2432 words

→

Stroke

disease · 1987 words

→

Pathway Diagram

graph TD
    SPI1["SPI1"]
    SPI1 -.biomarker for.-> Alzheimer_s_disease["Alzheimer's disease"]
    SPI1 -->|"target for"| Multiple_Sclerosis["Multiple Sclerosis"]
    SPI1 -->|"target for"| Alzheimer["Alzheimer"]
    SPI1 -->|"regulates"| Ms["Ms"]
    SPI1 -->|"target for"| Parkinson["Parkinson"]
    SPI1 -.biomarker for.-> Als["Als"]
    SPI1 -->|"activates"| Atherosclerosis["Atherosclerosis"]
    SPI1 -->|"activates"| Stroke["Stroke"]
    C1Q["C1Q"] -->|"expressed in"| SPI1
    C1QA["C1QA"] -->|"expressed in"| SPI1
    C1QC["C1QC"] -->|"expressed in"| SPI1
    CEBPA["CEBPA"] -->|"regulates"| SPI1
    HSPA1A["HSPA1A"] -->|"target for"| SPI1
    TFE3["TFE3"] -->|"regulates"| SPI1
    TP53["TP53"] -->|"regulates"| SPI1
    TRAF6["TRAF6"] -.biomarker for.-> SPI1
    P38["P38"] -.biomarker for.-> SPI1
    CD4["CD4"] -.biomarker for.-> SPI1

Outgoing (222)

Target	Relation	Type	Str
ds-83b31ef18d49	provides_data_for	dataset	1.00
ds-db4a006ea647	provides_data_for	dataset	1.00
Microglial/Macrophage Inflammatory Response	regulates	process	0.95
PI3K/AKT/MTOR Signaling Pathway	activates	pathway	0.90
Microglia	expressed_in	cell_type	0.90
C1QA	regulates	entity	0.85
C1QC	regulates	entity	0.85
Debris Clearance	associated_with	process	0.85
APOE	regulates	gene	0.85
Phagocytosis	upregulates	process	0.85
Autophagy	upregulates	process	0.85
Neuroinflammation	regulates	process	0.85
Remyelination	associated_with	process	0.80
Complement Activation	associated_with	process	0.80
Angiogenesis	associated_with	process	0.80
Glycolysis	upregulates	process	0.80
HSPB1	regulates	gene	0.80
Als	activates	disease	0.75
Alzheimer's disease	associated_with	disease	0.70
Alzheimer's disease	biomarker_for	disease	0.70
macrophages	expressed_in	cell_type	0.70
microglia	expressed_in	cell_type	0.70
Atherosclerosis	associated_with	disease	0.65
Stroke	associated_with	disease	0.65
Ms	associated_with	disease	0.65
Multiple Sclerosis	therapeutic_target	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Ms	regulates	disease	0.65
Parkinson	therapeutic_target	disease	0.65
Als	biomarker_for	disease	0.65
Atherosclerosis	activates	disease	0.65
Stroke	activates	disease	0.65
Alzheimer	associated_with	disease	0.65
Multiple Sclerosis	associated_with	disease	0.65
Parkinson	associated_with	disease	0.65
Parkinson	expressed_in	disease	0.65
Alzheimer	expressed_in	disease	0.65
Multiple Sclerosis	expressed_in	disease	0.65
Neuroinflammation	activates	disease	0.65
Inflammation	activates	disease	0.65
Alzheimer	activates	disease	0.65
Neurodegeneration	activates	disease	0.65
Cancer	regulates	disease	0.65
Alzheimer	regulates	disease	0.65
Als	associated_with	disease	0.65
Inflammation	regulates	disease	0.65
ALS	associated_with	disease	0.65
Cancer	activates	disease	0.65
MACROPHAGES	treats	cell_type	0.65
COMPLEMENT ACTIVATION	interacts_with	phenotype	0.65

Incoming (217)

Source	Relation	Type	Str
ds-83b31ef18d49	data_in	dataset	1.00
ds-db4a006ea647	data_in	dataset	1.00
ALZHEIMER'S DISEASE	associated_with	disease	0.82
APOE	activates	gene	0.70
STAT3	activates	gene	0.70
APOE	associated_with	gene	0.66
AMYLOID	associated_with	protein	0.66
GBM	associated_with	gene	0.60
C1Q	expressed_in	gene	0.60
C1QA	expressed_in	gene	0.60
C1QC	expressed_in	gene	0.60
CEBPA	regulates	gene	0.60
HSPA1A	therapeutic_target	gene	0.60
TFE3	regulates	gene	0.60
TRAF6	biomarker_for	gene	0.60
P38	biomarker_for	gene	0.60
CD4	biomarker_for	gene	0.60
EGR2	biomarker_for	gene	0.60
TNF	biomarker_for	gene	0.60
GBM	activates	gene	0.60
HSPA1A	associated_with	gene	0.60
FLNA	biomarker_for	gene	0.60
NFKBIA	biomarker_for	gene	0.60
JUNB	biomarker_for	gene	0.60
STXBP2	biomarker_for	gene	0.60
HSPA1A	expressed_in	gene	0.60
TREM2	activates	gene	0.60
TAU	activates	gene	0.60
GAIN	activates	gene	0.60
MMP12	activates	gene	0.60
CD33	activates	gene	0.60
TYROBP	activates	gene	0.60
IL6	activates	gene	0.60
JAK2	activates	gene	0.60
ABCA1	associated_with	entity	0.60
ABI3	associated_with	entity	0.60
ADAM17	associated_with	entity	0.60
CD2AP	associated_with	entity	0.60
CD33	associated_with	entity	0.60
CR1	associated_with	entity	0.60
CTSB	associated_with	entity	0.60
CTSH	associated_with	entity	0.60
EED	associated_with	entity	0.60
GRN	associated_with	entity	0.60
INPP5D	associated_with	entity	0.60
LILRB2	associated_with	entity	0.60
PICALM	associated_with	entity	0.60
PLCG2	associated_with	entity	0.60
PSEN1	associated_with	entity	0.60
PTK2B	associated_with	entity	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

How does SPI1 transcriptionally regulate C1QA and C1QC expression in atheroscler

neuroinflammation | 2026-04-08 | 0 hypotheses

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

SPI1

Understanding Entity Pages

Summary

Wiki Pages (21)

SPI1 Gene - PU.1

Microglia Activation Mechanism

Neuroinflammation and Microglia Pathway

GADD45G as Pathological Sensor: Orchestrating Reactive Gliosis in Neurodegeneration

iPSC-Derived Microglia

Stroke

KAT6A Gene

Disease-Associated [Microglia](/cell-types/microglia-neuroinflammation) (DAM)

CEBPE Gene

TBP - TATA-Box Binding Protein

GWAS Findings Hub: Alzheimer's and Parkinson's Disease

GWAS Findings Hub

LILRB2 — Leukocyte Immunoglobulin-Like Receptor B2

FLNA Gene

GATA2 - GATA Binding Protein 2

STXBP2 — Syntaxin Binding Protein 2

PU.1 Protein (SPI1)

MECOM Gene

CHRNE Gene

C1QC