Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Angiogenesis: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Angiogenesis is an entity related to neurodegeneration research. Key relationships include: activates, therapeutic target, regulates. Associated with ALS, Aging, Als. Connected to 759 entities in the SciDEX knowledge graph.
Knowledge base pages for this entity
graph TD
Angiogenesis["Angiogenesis"] -->|"interacts"| VEGF["VEGF"]
Angiogenesis["Angiogenesis"] -->|"interacts"| Pi3K["Pi3K"]
Angiogenesis["Angiogenesis"] -->|"interacts"| Glycolysis["Glycolysis"]
Angiogenesis["Angiogenesis"] -->|"interacts"| Adaptive_Immunity["Adaptive Immunity"]
Angiogenesis["Angiogenesis"] -->|"interacts"| Apoptosis["Apoptosis"]
Angiogenesis["Angiogenesis"] -->|"interacts"| Blood_Brain_Barrier["Blood-Brain Barrier"]
VEGF_1["VEGF"] -->|"regulates"| Angiogenesis["Angiogenesis"]
VEGF_2["VEGF"] -->|"interacts"| Angiogenesis["Angiogenesis"]
VEGF_3["VEGF"] -.->|"inhibits"| Angiogenesis["Angiogenesis"]
VEGF_4["VEGF"] -->|"implicated in"| Angiogenesis["Angiogenesis"]
style Angiogenesis fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Bone Fracture Healing | involved_in | process | 0.95 |
| Brain Development | involved_in | process | 0.95 |
| Wound Healing | involved_in | process | 0.95 |
| Wound Healing | contributes_to | process | 0.95 |
| Brain Vascular Malformations | associated_with | disease | 0.90 |
| Brain Tumors | associated_with | disease | 0.90 |
| Fracture Healing | contributes_to | process | 0.90 |
| VEGF | interacts_with | entity | 0.70 |
| Pi3K | interacts_with | pathway | 0.55 |
| Glycolysis | interacts_with | pathway | 0.55 |
| Adaptive Immunity | interacts_with | pathway | 0.55 |
| Apoptosis | interacts_with | pathway | 0.55 |
| Blood-Brain Barrier | interacts_with | pathway | 0.55 |
| Epigenetic | interacts_with | pathway | 0.55 |
| Notch | interacts_with | pathway | 0.55 |
| Mtor | interacts_with | pathway | 0.55 |
| Autophagy | interacts_with | pathway | 0.55 |
| Immune Response | interacts_with | pathway | 0.55 |
| Astrocyte | associated_with | cell_type | 0.50 |
| Stem Cell | associated_with | cell_type | 0.50 |
| Neuron | associated_with | cell_type | 0.50 |
| Macrophage | associated_with | cell_type | 0.50 |
| Microglia | associated_with | cell_type | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| MTOR | therapeutic_target | gene | 1.00 |
| AKT | activates | gene | 1.00 |
| Als | activates | disease | 1.00 |
| Cancer | activates | disease | 1.00 |
| Als | therapeutic_target | disease | 1.00 |
| Tumor | activates | disease | 1.00 |
| GENES | activates | gene | 1.00 |
| PI3K | activates | gene | 1.00 |
| Cancer | therapeutic_target | disease | 1.00 |
| Inflammation | therapeutic_target | disease | 1.00 |
| GENES | regulates | gene | 1.00 |
| Inflammation | inhibits | disease | 1.00 |
| Inflammation | activates | disease | 1.00 |
| Als | regulates | disease | 1.00 |
| PI3K | therapeutic_target | gene | 1.00 |
| AKT | therapeutic_target | gene | 1.00 |
| Tumor | therapeutic_target | disease | 1.00 |
| Als | inhibits | disease | 1.00 |
| Tumor | inhibits | disease | 1.00 |
| STAT3 | activates | gene | 1.00 |
| Tumor | regulates | disease | 1.00 |
| PI3K | regulates | gene | 1.00 |
| AKT | regulates | gene | 1.00 |
| CANCER | regulates | gene | 1.00 |
| APOPTOSIS | regulates | gene | 1.00 |
| CANCER | therapeutic_target | gene | 1.00 |
| INFLAMMATION | activates | gene | 1.00 |
| CANCER | activates | gene | 1.00 |
| APOPTOSIS | activates | gene | 1.00 |
| INFLAMMATION | inhibits | gene | 1.00 |
| APOPTOSIS | inhibits | gene | 1.00 |
| OXIDATIVE STRESS | activates | gene | 1.00 |
| Cancer | regulates | disease | 1.00 |
| CANCER | inhibits | gene | 1.00 |
| Cancer | inhibits | disease | 1.00 |
| Ischemia | activates | disease | 1.00 |
| VEGF | activates | gene | 1.00 |
| MTOR | regulates | gene | 1.00 |
| PI3K | inhibits | gene | 1.00 |
| AKT | inhibits | gene | 1.00 |
| TNF | activates | gene | 1.00 |
| TNF-Α | activates | gene | 1.00 |
| CYTOKINES | therapeutic_target | gene | 1.00 |
| MICRORNAS | regulates | gene | 1.00 |
| CYTOKINES | activates | gene | 1.00 |
| AUTOPHAGY | regulates | gene | 1.00 |
| INFLAMMATION | therapeutic_target | gene | 1.00 |
| Inflammation | regulates | disease | 1.00 |
| Als | interacts_with | disease | 0.95 |
| Tumor | associated_with | disease | 0.95 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||