Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about PICK1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | PICK1 |
| Full Name | Protein Interacting With C Kinase 1 |
| Aliases | Page for PICK1 |
| Protein Family | PDZ domain proteins |
| Protein Type | Scaffold Protein |
| Function | PICK1 (Protein Interacting with C Kinase 1) is a PDZ domain-containing scaffold protein that interacts with protein kinase C (PKC) and various membrane proteins including AMPA receptors, NMDA receptor |
| Molecular Weight | 46 kDa |
| Amino Acids | 436 aa |
| UniProt ID | Q9NRF5 |
| GeneCards | PICK1 |
| Human Protein Atlas | PICK1 |
| Dopamine transporter (DAT) | PICK1 interacts with DAT and influences dopamine reuptake efficiency[^8] |
| GLURδ2/GRID2 | Involved in cerebellar synaptic plasticity[^9] |
| NMDA receptor subunits | Some studies suggest indirect interactions through other scaffolding proteins[^10] |
| Associated Diseases | neurodegeneration |
| Interactions | JAK2, AKT1, CHRNA7, AND, Akt |
| KG Connections | 15 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
PICK1["PICK1"]
PICK1 -->|"interacts"| Als["Als"]
PICK1 -->|"interacts"| ALS["ALS"]
PICK1 -->|"interacts"| JAK2["JAK2"]
PICK1 -->|"interacts"| AKT1["AKT1"]
PICK1 -->|"interacts"| CHRNA7["CHRNA7"]
PICK1 -->|"interacts"| Neurogenesis["Neurogenesis"]
PICK1 -->|"interacts"| Neuron["Neuron"]
PICK1 -->|"interacts"| AND["AND"]
AKT1 -->|"interacts"| PICK1
CHRNA7 -->|"interacts"| PICK1
JAK2 -->|"interacts"| PICK1| Target | Relation | Type | Str |
|---|---|---|---|
| Als | interacts_with | disease | 0.65 |
| ALS | interacts_with | disease | 0.65 |
| JAK2 | interacts_with | gene | 0.60 |
| AKT1 | interacts_with | gene | 0.60 |
| CHRNA7 | interacts_with | gene | 0.60 |
| Neurogenesis | interacts_with | pathway | 0.60 |
| Neuron | interacts_with | cell_type | 0.60 |
| AND | interacts_with | gene | 0.60 |
| Akt | interacts_with | protein | 0.60 |
| Neuron | expressed_in | cell_type | 0.55 |
| disease | interacts_with | disease | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||