pathway

Neurogenesis

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about Neurogenesis: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1371Connections

2Hypotheses

2Analyses

50Outgoing

50Incoming

Summary

Neurogenesis is a biological pathway involved in neurodegeneration research. Key relationships include: activates, regulates, therapeutic target. Associated with ALS, Aging, Als. Connected to 510 entities in the SciDEX knowledge graph.

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🔀 Pathway Info

Name	Neurogenesis
Key Genes/Proteins	BDNF, APOPTOSIS, OXIDATIVE STRESS, NEURODEGENERATION, DEPRESSION, INFLAMMATION
Related Diseases	Inflammation, Neurodegeneration, Als, Depression, Neuroinflammation
Related Pathways	Notch Signaling
Linked Hypotheses	5 hypotheses

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    Neurogenesis["Neurogenesis"] -->|"interacts"| Notch["Notch"]
    Neurogenesis["Neurogenesis"] -->|"interacts"| Oxidative_Stress["Oxidative Stress"]
    Neurogenesis["Neurogenesis"] -->|"interacts"| Mitochondrial_Function["Mitochondrial Function"]
    Neurogenesis["Neurogenesis"] -->|"interacts"| Angiogenesis["Angiogenesis"]
    Neurogenesis["Neurogenesis"] -->|"interacts"| Apoptosis["Apoptosis"]
    Neurogenesis["Neurogenesis"] -->|"interacts"| Complement["Complement"]
    Alzheimer_s_Disease["Alzheimer's Disease"] -.->|"inhibits"| Neurogenesis["Neurogenesis"]
    SYP["SYP"] -->|"interacts"| Neurogenesis["Neurogenesis"]
    SYNCRIP["SYNCRIP"] -->|"interacts"| Neurogenesis["Neurogenesis"]
    GAIN["GAIN"] -.->|"inhibits"| Neurogenesis["Neurogenesis"]
    style Neurogenesis fill:#1b5e20,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (239)

Target	Relation	Type	Str
Post-Traumatic Brain Injury	involved_in	disease	0.88
Alzheimer's Disease	involved_in	disease	0.70
Notch	interacts_with	pathway	0.55
Oxidative Stress	interacts_with	pathway	0.55
Mitochondrial Function	interacts_with	pathway	0.55
Angiogenesis	interacts_with	pathway	0.55
Apoptosis	interacts_with	pathway	0.55
Complement	interacts_with	pathway	0.55
Nf-Κb	interacts_with	pathway	0.55
Synaptic Plasticity	interacts_with	pathway	0.55
Akt	interacts_with	pathway	0.55
Pi3K	interacts_with	pathway	0.55
SYNCRIP	interacts_with	concept	0.50
Proteins	interacts_with	protein	0.50
Myelination	activates	pathway	0.50
Astrocyte	inhibits	cell_type	0.50
Neuroinflammatory	inhibits	pathway	0.50
NEURONS	activates	concept	0.50
Cognitive Decline	associated_with	disease	0.50
Neuroprotection	activates	process	0.50
NEUROTOXICITY	associated_with	concept	0.50
Astrocyte	regulates	cell_type	0.50
Proteins	inhibits	protein	0.50
disease	associated_with	disease	0.50
ALZHEIMER'S	associated_with	concept	0.50
Neuron	inhibits	cell_type	0.50
Hippocampus	inhibits	entity	0.50
DENDRITIC SPINE	inhibits	concept	0.50
EXERCISE	activates	concept	0.50
NEUROTOXICITY	activates	concept	0.50
GLUTAMATE	activates	concept	0.50
DEMYELINATION	activates	concept	0.50
GUT-BRAIN AXIS	inhibits	concept	0.50
Myelination	inhibits	pathway	0.50
Alzheimer Disease	regulates	disease	0.50
disease	regulates	disease	0.50
NEURONS	inhibits	concept	0.50
STEM CELLS	inhibits	concept	0.50
Hippocampus	activates	entity	0.50
DENDRITIC SPINE	activates	concept	0.50
GUT-BRAIN AXIS	activates	concept	0.50
Cognitive Impairment	activates	phenotype	0.50
Neuroinflammatory	associated_with	pathway	0.50
Microbiota	activates	process	0.50
Gut Microbiota	activates	process	0.50
Erk Signaling	activates	pathway	0.50
Neuron	activates	cell_type	0.50
INTERNEURONS	activates	concept	0.50
INTERNEURONS	expressed_in	concept	0.50
AXON	activates	concept	0.50

Incoming (1132)

Source	Relation	Type	Str
BDNF	activates	gene	1.00
Inflammation	activates	disease	1.00
Neurodegeneration	activates	disease	1.00
Als	activates	disease	1.00
APOPTOSIS	activates	gene	1.00
OXIDATIVE STRESS	activates	gene	1.00
NEURODEGENERATION	activates	gene	1.00
Depression	activates	disease	1.00
Neuroinflammation	activates	disease	1.00
DEPRESSION	activates	gene	1.00
INFLAMMATION	activates	gene	1.00
CYTOKINES	activates	gene	1.00
NPY	promotes	protein	0.95
Exercise Training	promotes	process	0.92
Notch Signaling	inhibits	pathway	0.90
Exercise	upregulates	process	0.90
Adult Neural Stem Cells	involved_in	cell_type	0.90
AdipoRon	associated_with	drug	0.90
Aging	activates	disease	0.90
TNF	activates	gene	0.90
Tumor	activates	disease	0.90
NEUROINFLAMMATION	activates	gene	0.90
NEURODEGENERATION	implicated_in	gene	0.90
Als	implicated_in	disease	0.90
Neurodegeneration	implicated_in	disease	0.90
SOX2	involved_in	gene	0.88
Itaconate	promotes	compound	0.88
Alzheimer's Disease	inhibits	disease	0.85
MT1	involved_in	protein	0.85
MT2	involved_in	protein	0.85
Microglia Activation	regulates	process	0.85
Apbb1Ip	biomarker_for	biomarker	0.85
Aβ42	modulates	biomarker	0.85
METALLOTHIONEIN-I+II	associated_with	protein	0.85
HDAC3	modulates	gene	0.85
Α-SYNUCLEIN	inhibits	protein	0.85
Oxytocin	associated_with	drug	0.85
USP9X	involved_in	gene	0.85
Gut Microbiota	promotes	cell_type	0.82
Microglia	regulates	cell_type	0.80
METALLOTHIONEIN	associated_with	protein	0.80
Alzheimer'S Disease	causes	disease	0.80
Alzheimer	activates	disease	0.80
Parkinson	activates	disease	0.80
Neurodegeneration	therapeutic_target	disease	0.80
Als	therapeutic_target	disease	0.80
Inflammation	therapeutic_target	disease	0.80
Inflammation	inhibits	disease	0.80
Neuroinflammation	inhibits	disease	0.80
AKT	activates	gene	0.80

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna	0.677	Alzheimer's disease	Circuit-level neural dynamics in neurode
Hypocretin-Neurogenesis Coupling Therapy	0.452	neurodegeneration	Sleep disruption as cause and consequenc

Mentioning Analyses (2)

Scientific analyses that reference this entity

How does SYNGAP1, a 'synaptic' protein, function in pre-synaptic radial glia cel

neurodevelopment | 2026-04-15 | 1 hypotheses Top: 0.576

How do P/Q channel deficits paradoxically increase thalamic excitability despite

synaptic biology | 2026-04-14 | 1 hypotheses Top: 0.526

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
EMI1 switches from being a substrate to an inhibitor of APC/C(CDH1) to start the [PMID:29875408]	Cappell SD, Mark KG, Garbett D, Pack LR,	Nature	2018	1
Metabolic fate of glucose and candidate signaling and excess-fuel detoxification [PMID:28280244]	Mugabo Y, Zhao S, Lamontagne J, Al-Mass	J Biol Chem	2017	1
Sleep drives metabolite clearance from the adult brain. [PMID:24136970]	Xie L, Kang H, Xu Q, Chen MJ, Liao Y, Th	Science	2013	1
Exposure to 1800 MHz radiofrequency radiation induces oxidative damage to mitoch [PMID:19879861]	Xu S, Zhou Z, Zhang L, Yu Z, Zhang W, Wa	Brain Res	2010	1
Nucleotide signaling and cutaneous mechanisms of pain transduction. [PMID:19171165]	Dussor G, Koerber HR, Oaklander AL, Rice	Brain Res Rev	2009	1
Antidepressant effects of combined eucommia-gastrodia extract via modulation of [PMID:41921863]	Xue L, Pan Z, Liu Y, Gan Q, Liu D, Liu D	Brain research bulletin	2026	0
Complementary mechanisms of high-carbohydrate diets and ketogenic diets restore [PMID:41475465]	Kwon H, Seo DS, Ahmad Y, Park S, Yoo J,	The Journal of nutritional bio	2026	0
TrkB promotes the neuronal secretion of soluble Siglec-2 (CD22) to mitigate micr [PMID:41922794]	Shi X, Cai SZ, Chai JL, Xu CY, Zhou BY,	Molecular psychiatry	2026	0
The Potential Functions and Beneficial Effects of Melatonin on Cognitive Impairm [PMID:41917799]	Li XY, Cheng YZ, Zhang YM, Hu F, Fang SK	Brain and behavior	2026	0
Biomarkers for Alzheimer's disease across diverse biological domains: an umbrell [PMID:40680830]	Kang J, Son Y, Yim Y, Cho H, Kim J et al	J Adv Res	2026	0
Nanotherapeutic potential of Baicalein-encapsulated hUC-MSC exosomes in Alzheime [PMID:41370943]	Xu J, He Z, Pan Y, Cao B, Chen G	Biomater Adv	2026	0
Zhi-Gan Formula improved insomnia and anxiety comorbidity in a mouse model via P [PMID:41525914]	Liu R, Wu Z, Yin Y, Song C, Zhang C et a	J Ethnopharmacol	2026	0
Triterpenoid saponins from Platycodon grandiflorus exhibit antidepressant-like e [PMID:41539634]	Yoon S, Chun E, Iqbal H, Kim SH, Kim SY	J Ethnopharmacol	2026	0
Epigenetic mechanisms and therapeutic innovations in chronic pain-associated neu [PMID:41554641]	Zhang K, Zhu S, Xing N, Zhou Z, Chen J e	Br J Pharmacol	2026	0
Postbiotics and the gut-brain axis: A mechanistic review on modulating neuroinfl [PMID:41570486]	Lahariya R, Anand G, Kumari B, Priyadars	J Neuroimmunol	2026	0
miRNA-206 in muscle and central nervous system crosstalk during exercise: A doub [PMID:41571168]	Malvandi AM, Gerosa L, Maroni P, Orlando	Neurosci Biobehav Rev	2026	0
Experts' narrative review "Mastication, Hippocampal Structure Changes and Cognit [PMID:41576846]	Piancino MG	Arch Oral Biol	2026	0
Plant-derived bioactive compounds modulate the gut microbiota in Alzheimer's dis [PMID:41678917]	Xue D, Hu X, Li R, Sun T, Qian S et al.	Phytomedicine	2026	0
Dysregulation of Drp1 and Mfn2 is associated with reduced PSD-95, synaptophysin, [PMID:41932483]	Alfateh M, Vasconcelos C, Choker AH, Moh	Int J Biol Macromol	2026	0
AICAR improves depression-like behaviors and is associated with hippocampal AMPK [PMID:41932583]	Takahashi K, Kurokawa K, Kawaguchi R, Ta	Neurochem Int	2026	0

Neurogenesis

Understanding Entity Pages

Summary

Wiki Pages (20)

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CBS/PSP Treatment Rankings

Alzheimer's Disease

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PD Cure Roadmap

Microglial Cells — Cell Type Hierarchy

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Growth Factor Therapies

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Autophagy Mechanisms