protein

PON1PROTEIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PON1PROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

The paraoxonase gene family consists of three members—PON1, PON2, and PON3—located in a cluster on chromosome 7q21.3.

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🔬 Protein Info

Gene Symbol	PON1PROTEIN
Chromosome	7q21.3.
Function	is a calcium-dependent esterase primarily synthesized in the liver and associated with high-density lipoprotein (HDL) particles in plasma.
Primary Expression	neurons, astrocytes, and microglia, where it contributes to neuroprotection through multiple mechanisms including antioxidant activity, anti-inflammat
Subcellular Localization	** \| Plasma (HDL-associated), Liver, Kidney \|
Molecular Weight	43 kDa
Amino Acids	354 aa
Exons	9
GeneCards	PON1PROTEIN
Human Protein Atlas	PON1PROTEIN
Q192R (rs662)	Glutamine to arginine substitution at position 192, affecting substrate specificity and activity levels
L55M (rs854560)	Leucine to methionine substitution, influencing enzyme expression
C(-108)T (rs705379)	Promoter variant affecting transcription levels
Associated Diseases	Als, Atherosclerosis, Breast Cancer, Cancer, Depression, Inflammation
Interactions	CLU
KG Connections	45 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

pon1-protein

protein · 2351 words

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Pathway Diagram

graph TD
    PON1PROTEIN["PON1PROTEIN"]
    neurodegeneration["neurodegeneration"]
    PON1PROTEIN -->|"implicated_in"| neurodegeneration
    style PON1PROTEIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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No outgoing edges

Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning PON1PROTEIN in their description or question text

No additional research found