Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about PROTO-ONCOGENES: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | PROTO-ONCOGENES |
| Key Genes/Proteins | CYTOKINES, ONCOGENES, AND, APOPTOSIS, CANCER, P53 |
| Related Diseases | Tumor, Cancer, ALS |
| Related Pathways | Signal Transduction, Cell Cycle, Apoptosis |
Knowledge base pages for this entity
graph TD
PROTO_ONCOGENES["PROTO-ONCOGENES"]
PROTO_ONCOGENES -->|"involved_in"| Signal_Transduction["Signal Transduction"]
PROTO_ONCOGENES -->|"inhibits"| Tumor["Tumor"]
PROTO_ONCOGENES -->|"activates"| Cancer["Cancer"]
PROTO_ONCOGENES -->|"activates"| ALS["ALS"]
PROTO_ONCOGENES -->|"activates"| CYTOKINES["CYTOKINES"]
PROTO_ONCOGENES -->|"inhibits"| ONCOGENES["ONCOGENES"]
PROTO_ONCOGENES -->|"inhibits"| AND["AND"]
PROTO_ONCOGENES -->|"activates"| APOPTOSIS["APOPTOSIS"]
GENES["GENES"] -->|"inhibits"| PROTO_ONCOGENES
TUMOR_SUPPRESSOR_GENES["TUMOR SUPPRESSOR GENES"] -->|"inhibits"| PROTO_ONCOGENES
APOPTOSIS -->|"activates"| PROTO_ONCOGENES
CANCER["CANCER"] -->|"activates"| PROTO_ONCOGENES
AND -->|"inhibits"| PROTO_ONCOGENES
P53["P53"] -->|"activates"| PROTO_ONCOGENES
ONCOGENES -->|"inhibits"| PROTO_ONCOGENES| Target | Relation | Type | Str |
|---|---|---|---|
| Signal Transduction | involved_in | pathway | 0.90 |
| Tumor | inhibits | disease | 0.65 |
| Cancer | activates | disease | 0.65 |
| ALS | activates | disease | 0.65 |
| CYTOKINES | activates | gene | 0.60 |
| ONCOGENES | inhibits | gene | 0.60 |
| AND | inhibits | gene | 0.60 |
| APOPTOSIS | activates | gene | 0.60 |
| CANCER | activates | gene | 0.60 |
| P53 | activates | gene | 0.60 |
| Cell Cycle | activates | pathway | 0.60 |
| Apoptosis | activates | pathway | 0.60 |
| GENES | inhibits | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||