Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about TUMOR SUPPRESSOR GENES: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
No summary available yet. View on Wiki →
| Name | TUMOR SUPPRESSOR GENES |
| Key Genes/Proteins | AND, HLA, CANCER, P53 |
| Related Diseases | Tumor, Cancer, ALS, Carcinoma, Aging |
| Related Pathways | Signal Transduction |
Knowledge base pages for this entity
graph TD
TUMOR_SUPPRESSOR_GENES["TUMOR SUPPRESSOR GENES"]
TUMOR_SUPPRESSOR_GENES -->|"involved_in"| Carcinogenesis["Carcinogenesis"]
TUMOR_SUPPRESSOR_GENES -->|"involved_in"| Signal_Transduction["Signal Transduction"]
TUMOR_SUPPRESSOR_GENES -->|"inhibits"| Tumor["Tumor"]
TUMOR_SUPPRESSOR_GENES -->|"inhibits"| Cancer["Cancer"]
TUMOR_SUPPRESSOR_GENES -->|"activates"| ALS["ALS"]
TP53["TP53"] -->|"inhibits"| TUMOR_SUPPRESSOR_GENES
GENES["GENES"] -->|"inhibits"| TUMOR_SUPPRESSOR_GENES
APC["APC"] -->|"inhibits"| TUMOR_SUPPRESSOR_GENES
DNA["DNA"] -->|"contributes to"| TUMOR_SUPPRESSOR_GENES
NRF2["NRF2"] -->|"inhibits"| TUMOR_SUPPRESSOR_GENES
CANCER["CANCER"] -->|"inhibits"| TUMOR_SUPPRESSOR_GENES
APOPTOSIS["APOPTOSIS"] -->|"activates"| TUMOR_SUPPRESSOR_GENES| Target | Relation | Type | Str |
|---|---|---|---|
| Carcinogenesis | involved_in | process | 0.93 |
| Signal Transduction | involved_in | pathway | 0.90 |
| Tumor | inhibits | disease | 0.65 |
| Cancer | inhibits | disease | 0.65 |
| ALS | activates | disease | 0.65 |
| Tumor | activates | disease | 0.65 |
| Cancer | causes | disease | 0.65 |
| ALS | causes | disease | 0.65 |
| Carcinoma | causes | disease | 0.65 |
| Cancer | contributes_to | disease | 0.65 |
| Aging | contributes_to | disease | 0.65 |
| AND | interacts_with | gene | 0.60 |
| HLA | interacts_with | gene | 0.60 |
| CANCER | inhibits | gene | 0.60 |
| P53 | inhibits | gene | 0.60 |
| PROTO-ONCOGENES | inhibits | gene | 0.60 |
| CYTOKINES | activates | gene | 0.60 |
| ONCOGENES | inhibits | gene | 0.60 |
| AND | inhibits | gene | 0.60 |
| APOPTOSIS | activates | gene | 0.60 |
| P53 | activates | gene | 0.60 |
| Cell Cycle | activates | pathway | 0.60 |
| Apoptosis | activates | pathway | 0.60 |
| ONCOGENES | activates | gene | 0.60 |
| AND | activates | gene | 0.60 |
| CANCER | causes | gene | 0.60 |
| Angiogenesis | activates | pathway | 0.60 |
| P21 | inhibits | gene | 0.60 |
| RB1 | inhibits | gene | 0.60 |
| OXIDATIVE STRESS | contributes_to | gene | 0.60 |
| ROS | contributes_to | gene | 0.60 |
| KEAP1 | inhibits | gene | 0.60 |
| CANCER | contributes_to | gene | 0.60 |
| Oxidative Stress | contributes_to | pathway | 0.60 |
| Dna Repair | contributes_to | pathway | 0.60 |
| HLA-A | interacts_with | gene | 0.60 |
| TP53 | inhibits | gene | 0.60 |
| GENES | inhibits | gene | 0.60 |
| GENES | activates | gene | 0.60 |
| T Cell | expressed_in | cell_type | 0.55 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||