Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about PI3K/AKT/MTOR SIGNALING PATHWAY: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
No summary available yet. View on Wiki →
| Name | PI3K/AKT/MTOR SIGNALING PATHWAY |
Knowledge base pages for this entity
graph TD
PI3K_AKT_MTOR_SIGNALING_PATHWA["PI3K/AKT/MTOR SIGNALING PATHWAY"]
PI3K_AKT_MTOR_SIGNALING_PATHWA -->|"contributes to"| Triple_Negative_Breast_Cancer_["Triple-Negative Breast Cancer Growth"]
PI3K_AKT_MTOR_SIGNALING_PATHWA -->|"regulates"| Autophagy["Autophagy"]
PI3K_AKT_MTOR_SIGNALING_PATHWA -->|"regulates"| Skeletal_Muscle_Aging["Skeletal Muscle Aging"]
PI3K_AKT_MTOR_SIGNALING_PATHWA -->|"contributes to"| Angiogenesis["Angiogenesis"]
PI3K_AKT_MTOR_SIGNALING_PATHWA -->|"contributes to"| Breast_Cancer_Proliferation["Breast Cancer Proliferation"]
PI3K_AKT_MTOR_SIGNALING_PATHWA -->|"contributes to"| Breast_Cancer_Survival["Breast Cancer Survival"]
PI3K_AKT_MTOR_SIGNALING_PATHWA -->|"inhibits"| Ferroptosis["Ferroptosis"]
Polygonatum_Sibiricum_Polysacc["Polygonatum Sibiricum Polysaccharide"] -->|"activates"| PI3K_AKT_MTOR_SIGNALING_PATHWA
Curcumin["Curcumin"] -->|"inhibits"| PI3K_AKT_MTOR_SIGNALING_PATHWA
SPI1["SPI1"] -->|"activates"| PI3K_AKT_MTOR_SIGNALING_PATHWA
LY294002["LY294002"] -->|"inhibits"| PI3K_AKT_MTOR_SIGNALING_PATHWA| Target | Relation | Type | Str |
|---|---|---|---|
| Triple-Negative Breast Cancer Growth | contributes_to | phenotype | 0.95 |
| Cancer Stem Cell Maintenance | involved_in | process | 0.95 |
| Cancer Stem Cell Proliferation | activates | process | 0.93 |
| Skeletal Muscle Aging | regulates | process | 0.90 |
| Breast Cancer Proliferation | contributes_to | phenotype | 0.90 |
| Breast Cancer Survival | contributes_to | phenotype | 0.90 |
| Skeletal Muscle Aging | regulates | phenotype | 0.90 |
| Epithelial To Mesenchymal Transition | regulates | process | 0.90 |
| Breast Cancer Progression | mediates | disease | 0.90 |
| Autophagy | regulates | process | 0.90 |
| Angiogenesis | contributes_to | process | 0.90 |
| Ferroptosis | inhibits | process | 0.88 |
| Autophagy | modulates | process | 0.88 |
| Cancer Stem Cell Migration | involved_in | process | 0.87 |
| Therapy Resistance | contributes_to | process | 0.85 |
| Microglial/Macrophage Inflammatory Response | mediates | process | 0.85 |
| Drug Resistance In Tumors | associated_with | phenotype | 0.85 |
| Ferroptosis | regulates | process | 0.85 |
| Mitochondrial Dysfunction | regulates | process | 0.85 |
| Mitochondrial Function | regulates | process | 0.85 |
| neuroinflammation | regulates | process | 0.80 |
| Source | Relation | Type | Str |
|---|---|---|---|
| Polygonatum Sibiricum Polysaccharide | activates | compound | 0.95 |
| CircRNA | modulates | biomarker | 0.95 |
| Curcumin | inhibits | compound | 0.92 |
| PI3K/Akt/mTOR Inhibitors | inhibits | drug | 0.92 |
| SPI1 | activates | gene | 0.90 |
| LY294002 | inhibits | compound | 0.90 |
| LY294002 | inhibits | drug | 0.90 |
| MTOR | activates | gene | 0.90 |
| Polygonatum Sibiricum Polysaccharide | activates | compound | 0.85 |
| Polygonatum sibiricum polysaccharide (PSP) | activates | compound | 0.80 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||