cell_type

Primary Cilia

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about Primary Cilia: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

15Connections
0Hypotheses
0Analyses
12Outgoing
2Incoming

No summary available yet. View on Wiki →

🧫 Cell Type Info
Cell TypePrimary Cilia
Key MarkersSHH, MFN2
Key PathwaysCiliary Signaling Pathways, Signaling Pathways
Associated DiseasesAlzheimer's Disease, Parkinson's Disease, Amyotrophic Lateral Sclerosis, Stroke, brain disorders

Wiki Pages (20)

Knowledge base pages for this entity

PTCH2 Gene

gene · 3361 words

GLI1 — GLI Family Zinc Finger 1

gene · 3218 words

Endolysosomal Trafficking Defects in Neurodegeneration

mechanism · 3115 words

GPR161 — G Protein-Coupled Receptor 161

gene · 2976 words

Hedgehog Signaling Pathway in Neurodegeneration

mechanism · 2948 words

Pathway Diagram

graph TD
    Primary_Cilia["Primary Cilia"] -->|"mediates"| Ciliary_Signaling_Pathways["Ciliary Signaling Pathways"]
    style Ciliary_Signaling_Pathways fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    Primary_Cilia["Primary Cilia"] -->|"expressed in"| NEURON["NEURON"]
    style NEURON fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    Primary_Cilia["Primary Cilia"] -->|"expressed in"| ASTROCYTES["ASTROCYTES"]
    style ASTROCYTES fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    Primary_Cilia["Primary Cilia"] -->|"regulates"| Signaling_Pathways["Signaling Pathways"]
    style Signaling_Pathways fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    Primary_Cilia["Primary Cilia"] -->|"expressed in"| Neurons["Neurons"]
    style Neurons fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    Primary_Cilia["Primary Cilia"] -->|"regulates"| NEURODEGENERATION["NEURODEGENERATION"]
    style NEURODEGENERATION fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    Primary_Cilia["Primary Cilia"] -->|"involved in"| Alzheimer_s_Disease["Alzheimer's Disease"]
    style Alzheimer_s_Disease fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    SHH["SHH"] -->|"binds"| Primary_Cilia["Primary Cilia"]
    style SHH fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    style Primary_Cilia fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (13)

TargetRelationTypeStr
Ciliary Signaling Pathwaysmediatespathway0.90
NEURONexpressed_incell_type0.90
ASTROCYTESexpressed_incell_type0.90
Signaling Pathwaysregulatespathway0.90
Astrocytesexpressed_incell_type0.85

Incoming (2)

SourceRelationTypeStr
SHHbindsprotein0.85
SHHinteracts_withprotein0.85

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found