SHH

Understanding Entity Pages

This page aggregates everything SciDEX knows about SHH: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

Sonic Hedgehog signaling in neurodevelopment, neurodegeneration, and regenerative therapy

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flowchart TD
    CSNK1D["CSNK1D"] -->|"regulates"| SHH["SHH"]
    SHH["SHH"] -->|"associated with"| Stroke["Stroke"]
    SHH["SHH"] -->|"associated with"| Amyotrophic_Lateral_Scler["Amyotrophic Lateral Sclerosis"]
    SHH["SHH"] -->|"associated with"| Alzheimer["Alzheimer"]
    SHH["SHH"] -->|"regulates"| Als["Als"]
    SHH["SHH"] -->|"associated with"| Parkinson["Parkinson"]
    SHH["SHH"] -->|"associated with"| Aging["Aging"]
    SHH["SHH"] -->|"therapeutic target"| Ms["Ms"]
    SHH["SHH"] -->|"therapeutic target"| Inflammation["Inflammation"]
    SHH["SHH"] -->|"therapeutic target"| Autoimmune["Autoimmune"]
    SHH["SHH"] -->|"regulates"| Ms["Ms"]
    SHH["SHH"] -->|"activates"| Tumor["Tumor"]
    style CSNK1D fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style SHH fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style Stroke fill:#ef5350,stroke:#333,color:#e0e0e0
    style Amyotrophic_Lateral_Scler fill:#ef5350,stroke:#333,color:#e0e0e0
    style Alzheimer fill:#ef5350,stroke:#333,color:#e0e0e0
    style Als fill:#ef5350,stroke:#333,color:#e0e0e0
    style Parkinson fill:#ef5350,stroke:#333,color:#e0e0e0
    style Aging fill:#ef5350,stroke:#333,color:#e0e0e0
    style Ms fill:#ef5350,stroke:#333,color:#e0e0e0
    style Inflammation fill:#ef5350,stroke:#333,color:#e0e0e0
    style Autoimmune fill:#ef5350,stroke:#333,color:#e0e0e0
    style Tumor fill:#ef5350,stroke:#333,color:#e0e0e0