protein

RELAPROTEIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about RELAPROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

RELA (also known as p65) is the key transcriptional activator subunit of the Nuclear Factor kappa-B (NF-κB) transcription factor complex.

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🔬 Protein Info

Gene Symbol	RELAPROTEIN
Full Name	RELA (p65)
Protein Type	Protein
Function	is a major driver of neuroinflammation, a hallmark pathological feature of Alzheimer's disease (AD), Parkinson's disease (PD), and amyotrophic lateral sclerosis (ALS).
Primary Expression	neurons, astrocytes, microglia, and oligodendrocytes, where it
Amino Acids	300 aa
UniProt ID	Search UniProt
GeneCards	RELAPROTEIN
Human Protein Atlas	RELAPROTEIN
Rel Homology Domain (RHD)	The N-terminal ~300 amino acids comprise the RHD, which mediates DNA binding, dimerization, and interaction with IκB inhibitors
Transactivation Domain (TAD)	The C-terminal region contains two TADs (TAD1 and TAD2) that recruit transcriptional coactivators including CBP/p300
RHD	Enables dimerization with p50, p52, c-Rel, or RELB to form functional NF-κB dimers
Inflammatory mediators	TNF-α, IL-1β, IL-6, COX-2, iNOS
Anti-apoptotic proteins	Bcl-2, Bcl-xL, c-IAP1/2, XIAP
Acute phase proteins	CRP, serum amyloid A
Associated Diseases	Aging, Als, Cancer, Glioblastoma, Hepatitis, Inflammation
Known Drugs/Compounds	RESVERATROL
Interactions	AKT, AKT1, ALZHEIMER, ALZHEIMER DISEASE, AMYLOID, AND
KG Connections	755 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: RELAPROTEIN — AlphaFold SEARCH Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

RELA (p65) Protein

protein · 1037 words

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Pathway Diagram

graph TD
    RELAPROTEIN["RELAPROTEIN"]
    neurodegeneration["neurodegeneration"]
    RELAPROTEIN -->|"implicated_in"| neurodegeneration
    style RELAPROTEIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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Mentioning Analyses (0)

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

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Related Research

Hypotheses and analyses mentioning RELAPROTEIN in their description or question text

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