protein

RORAPROTEIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about RORAPROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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🔬 Protein Info

Gene Symbol	RORAPROTEIN
Protein Type	Receptor
Function	is a nuclear receptor transcription factor encoded by the RORA gene.
Primary Expression	the brain: - Cerebellum: Purkinje cells show highest expression - Hippocampus: CA1-CA3 pyramidal [neurons](/enti
Molecular Weight	59 kDa
GeneCards	RORAPROTEIN
Human Protein Atlas	RORAPROTEIN
N-terminal activation domain (AF-1)	Contains phosphorylation sites for regulation
DNA-binding domain (DBD)	Two zinc finger motifs that recognize ROREs
Hinge region	Flexible linker connecting DBD to LBD
Ligand-binding domain (LBD)	Binds heme, cholesterol, and other ligands
C-terminal activation domain (AF-2)	Required for transcriptional coactivator recruitment
Heme	Binds with micromolar affinity, may link to metabolic state
Cholesterol	Potential endogenous ligand
Retinoids	All-trans retinoic acid may modulate activity
Associated Diseases	Als, Alzheimer, Autoimmune, Cancer, Carcinoma, Diabetes
Interactions	Actin, ALZHEIMER, ALZHEIMER'S DISEASE, App, APP, AUTOPHAGY
KG Connections	122 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

RORα Protein

protein · 781 words

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Pathway Diagram

graph TD
    RORAPROTEIN["RORAPROTEIN"]
    neurodegeneration["neurodegeneration"]
    RORAPROTEIN -->|"implicated_in"| neurodegeneration
    style RORAPROTEIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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Mentioning Analyses (0)

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Related Research

Hypotheses and analyses mentioning RORAPROTEIN in their description or question text

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