Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about RPA3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | RPA3 |
| Full Name | Replication Protein A3 |
| Chromosome | 7q32.3 |
| Function | is a subunit of the heterotrimeric Replication Protein A complex (RPA), the major single-stranded DNA (ssDNA)-binding protein in eukaryotic cells. |
| Molecular Weight | 70 kDa |
| UniProt ID | [P35274](https://www.uniprot.org/uniprot/P35274) |
| Ensembl ID | ENSG00000186871 |
| GeneCards | RPA3 |
| Human Protein Atlas | RPA3 |
| RPA1 (RPA70) | 70 kDa subunit - contains multiple DNA-binding domains (DBDs) and protein interaction domains |
| RPA2 (RPA32) | 32 kDa subunit - phosphorylated in response to DNA damage, regulates protein interactions |
| RPA3 (RPA14) | 14 kDa subunit - smallest subunit, essential for complex assembly and stability |
| Associated Diseases | Cancer, Glioblastoma, Ms, Tumor |
| KG Connections | 8 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
RPA3["<b>RPA3</b>"]
Ms{"Ms"}
RPA3 -->|"associated with"| Ms
Cancer{"Cancer"}
RPA3 -->|"associated with"| Cancer
Tumor{"Tumor"}
RPA3 -->|"associated with"| Tumor
Glioblastoma{"Glioblastoma"}
RPA3 -->|"associated with"| Glioblastoma
CANCER["CANCER"]
RPA3 -->|"associated with"| CANCER
GBM["GBM"]
RPA3 -->|"biomarker for"| GBM
TUBB2A["TUBB2A"]
RPA3 -->|"biomarker for"| TUBB2A
neurodegeneration["neurodegeneration"]
RPA3 -->|"implicated in"| neurodegeneration
SSBP1["SSBP1"]
SSBP1 -->|"biomarker for"| RPA3
style RPA3 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Source | Relation | Type | Str |
|---|---|---|---|
| SSBP1 | biomarker_for | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||