Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about SSBP1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
SSBP1 is a gene implicated in neurodegeneration research. Key relationships include: associated with, biomarker for, activates. Associated with Cancer, Glioblastoma, Ms. Connected to 15 entities in the SciDEX knowledge graph.
| Gene Symbol | SSBP1 |
| Chromosome | 14q12 |
| Function | encodes a mitochondrial single-stranded DNA-binding protein essential for mitochondrial DNA (mtDNA) maintenance, replication, and repair. |
| Molecular Weight | 17 kDa |
| Amino Acids | 172 aa |
| Pathways | Apoptosis, Mitochondrial Function |
| GeneCards | SSBP1 |
| Human Protein Atlas | SSBP1 |
| POLG | Direct binding |
| TWINKLE | Direct binding |
| TFB2M | Indirect |
| mtSSB | Self |
| TFAM | Indirect |
| Associated Diseases | ALS, Alzheimer, Cancer, Glioblastoma, Ms |
| Interactions | HSF1, DRP1, CALB1, RNF14, CCT4, ULK2 |
| KG Connections | 103 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
SSBP1["<b>SSBP1</b>"]
mtDNA["mtDNA"]
SSBP1 -->|"regulates"| mtDNA
Ms{"Ms"}
SSBP1 -->|"associated with"| Ms
Cancer{"Cancer"}
SSBP1 -->|"associated with"| Cancer
Tumor{"Tumor"}
SSBP1 -->|"associated with"| Tumor
Glioblastoma{"Glioblastoma"}
SSBP1 -->|"associated with"| Glioblastoma
SSBP1 -->|"activates"| Tumor
RPA3["RPA3"]
SSBP1 -->|"biomarker for"| RPA3
CANCER["CANCER"]
SSBP1 -->|"associated with"| CANCER
GBM["GBM"]
SSBP1 -->|"biomarker for"| GBM
TUBB2A["TUBB2A"]
SSBP1 -->|"biomarker for"| TUBB2A
APOPTOSIS["APOPTOSIS"]
SSBP1 -->|"activates"| APOPTOSIS
MUL1["MUL1"]
SSBP1 -->|"associated with"| MUL1
HSF1["HSF1"]
HSF1 -->|"inhibits"| SSBP1
style SSBP1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| mtDNA | regulates | DNA | 0.70 |
| Ms | associated_with | disease | 0.65 |
| Cancer | associated_with | disease | 0.65 |
| Tumor | associated_with | disease | 0.65 |
| Glioblastoma | associated_with | disease | 0.65 |
| Tumor | activates | disease | 0.65 |
| Huntington | activates | disease | 0.65 |
| Neurodegeneration | activates | disease | 0.65 |
| Ms | activates | disease | 0.65 |
| Alzheimer | associated_with | disease | 0.65 |
| Als | associated_with | disease | 0.65 |
| ALS | associated_with | disease | 0.65 |
| RPA3 | biomarker_for | gene | 0.60 |
| GBM | biomarker_for | gene | 0.60 |
| TUBB2A | biomarker_for | gene | 0.60 |
| MUL1 | associated_with | gene | 0.60 |
| HSF1 | inhibits | gene | 0.60 |
| DRP1 | activates | gene | 0.60 |
| PRDX3 | associated_with | gene | 0.60 |
| APP | associated_with | gene | 0.60 |
| APOE | associated_with | gene | 0.60 |
| SYNE2 | associated_with | gene | 0.60 |
| SMARCB1 | associated_with | gene | 0.60 |
| ULK2 | associated_with | gene | 0.60 |
| TMEM59 | associated_with | gene | 0.60 |
| SFPQ | associated_with | gene | 0.60 |
| CCT4 | associated_with | gene | 0.60 |
| CALB1 | associated_with | gene | 0.60 |
| SORL1 | associated_with | gene | 0.60 |
| IGF2R | associated_with | gene | 0.60 |
| STXBP3 | associated_with | gene | 0.60 |
| RNF14 | associated_with | gene | 0.60 |
| SYNCRIP | associated_with | gene | 0.60 |
| IDS | associated_with | gene | 0.60 |
| SYNE2 | interacts_with | gene | 0.60 |
| TMEM59 | interacts_with | gene | 0.60 |
| CANCER | associated_with | gene | 0.60 |
| APOPTOSIS | activates | gene | 0.60 |
| Apoptosis | activates | pathway | 0.60 |
| MTDNA | inhibits | gene | 0.60 |
| MITOCHONDRIA | inhibits | gene | 0.60 |
| MITOCHONDRIAL DYSFUNCTION | activates | gene | 0.60 |
| NEURODEGENERATION | activates | gene | 0.60 |
| HUNTINGTON | activates | gene | 0.60 |
| DNA | inhibits | gene | 0.60 |
| Mitochondrial Function | activates | pathway | 0.60 |
| AND | inhibits | gene | 0.60 |
| MITOCHONDRIAL DNA | inhibits | gene | 0.60 |
| HUNTINGTON'S DISEASE | activates | gene | 0.60 |
| ALZHEIMER | associated_with | gene | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| HSF1 | inhibits | protein | 0.70 |
| IDS | associated_with | gene | 0.60 |
| SYNCRIP | associated_with | gene | 0.60 |
| TMEM59 | associated_with | gene | 0.60 |
| APOE | associated_with | gene | 0.60 |
| PRDX3 | associated_with | gene | 0.60 |
| RNF14 | associated_with | gene | 0.60 |
| ULK2 | associated_with | gene | 0.60 |
| CCT4 | associated_with | gene | 0.60 |
| SFPQ | associated_with | gene | 0.60 |
| CALB1 | associated_with | gene | 0.60 |
| SYNE2 | associated_with | gene | 0.60 |
| IGF2R | associated_with | gene | 0.60 |
| SMARCB1 | associated_with | gene | 0.60 |
| SORL1 | associated_with | gene | 0.60 |
| APP | associated_with | gene | 0.60 |
| STXBP3 | associated_with | gene | 0.60 |
| APP | interacts_with | gene | 0.60 |
| CALB1 | interacts_with | gene | 0.60 |
| CCT4 | interacts_with | gene | 0.60 |
| IDS | interacts_with | gene | 0.60 |
| IGF2R | interacts_with | gene | 0.60 |
| RNF14 | interacts_with | gene | 0.60 |
| SFPQ | interacts_with | gene | 0.60 |
| SORL1 | interacts_with | gene | 0.60 |
| HUNTINGTON'S DISEASE | activates | gene | 0.60 |
| MITOCHONDRIAL DNA | inhibits | gene | 0.60 |
| AND | inhibits | gene | 0.60 |
| ALZHEIMER | associated_with | gene | 0.60 |
| COPA | associated_with | gene | 0.60 |
| COPA | interacts_with | gene | 0.60 |
| APOE | interacts_with | gene | 0.50 |
| SYNE2 | interacts_with | gene | 0.50 |
| SMARCB1 | interacts_with | gene | 0.50 |
| TMEM59 | interacts_with | gene | 0.50 |
| PRDX3 | interacts_with | gene | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||