gene

SSBP1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SSBP1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

103Connections
0Hypotheses
0Analyses
50Outgoing
36Incoming

Summary

SSBP1 is a gene implicated in neurodegeneration research. Key relationships include: associated with, biomarker for, activates. Associated with Cancer, Glioblastoma, Ms. Connected to 15 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolSSBP1
Chromosome14q12
Functionencodes a mitochondrial single-stranded DNA-binding protein essential for mitochondrial DNA (mtDNA) maintenance, replication, and repair.
Molecular Weight17 kDa
Amino Acids172 aa
PathwaysApoptosis, Mitochondrial Function
GeneCardsSSBP1
Human Protein AtlasSSBP1
POLGDirect binding
TWINKLEDirect binding
TFB2MIndirect
mtSSBSelf
TFAMIndirect
Associated DiseasesALS, Alzheimer, Cancer, Glioblastoma, Ms
InteractionsHSF1, DRP1, CALB1, RNF14, CCT4, ULK2
KG Connections103 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Wiki Pages (16)

Knowledge base pages for this entity

Canonical Page

SSBP1 Gene

gene · 1253 words

CALB1 (Calbindin 1)

gene · 2669 words

IDS — Iduronate Sulfatase

gene · 2084 words

TK2 Gene

gene · 1474 words

Mitochondrial DNA Replication

mechanism · 1389 words

RPA3

gene · 1338 words

Pathway Diagram

graph TD
    SSBP1["<b>SSBP1</b>"]
    mtDNA["mtDNA"]
    SSBP1 -->|"regulates"| mtDNA
    Ms{"Ms"}
    SSBP1 -->|"associated with"| Ms
    Cancer{"Cancer"}
    SSBP1 -->|"associated with"| Cancer
    Tumor{"Tumor"}
    SSBP1 -->|"associated with"| Tumor
    Glioblastoma{"Glioblastoma"}
    SSBP1 -->|"associated with"| Glioblastoma
    SSBP1 -->|"activates"| Tumor
    RPA3["RPA3"]
    SSBP1 -->|"biomarker for"| RPA3
    CANCER["CANCER"]
    SSBP1 -->|"associated with"| CANCER
    GBM["GBM"]
    SSBP1 -->|"biomarker for"| GBM
    TUBB2A["TUBB2A"]
    SSBP1 -->|"biomarker for"| TUBB2A
    APOPTOSIS["APOPTOSIS"]
    SSBP1 -->|"activates"| APOPTOSIS
    MUL1["MUL1"]
    SSBP1 -->|"associated with"| MUL1
    HSF1["HSF1"]
    HSF1 -->|"inhibits"| SSBP1
    style SSBP1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (67)

TargetRelationTypeStr
mtDNAregulatesDNA0.70
Msassociated_withdisease0.65
Cancerassociated_withdisease0.65
Tumorassociated_withdisease0.65
Glioblastomaassociated_withdisease0.65

Incoming (36)

SourceRelationTypeStr
HSF1inhibitsprotein0.70
IDSassociated_withgene0.60
SYNCRIPassociated_withgene0.60
TMEM59associated_withgene0.60
APOEassociated_withgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found