Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about STMN1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Comprehensive coverage of STMN1 (Stathmin 1) in microtubule dynamics, neuronal development, synaptic plasticity, and neurodegenerative diseases including AD/PD/ALS.
| Gene Symbol | STMN1 |
| Full Name | Stathmin 1 |
| Chromosome | 1p36.11 |
| Function | is a 143-amino acid phosphoprotein that serves as a master regulator of microtubule dynamics in all eukaryotic cells. |
| Molecular Weight | 19 kDa |
| Amino Acids | 149 aa |
| Exons | 5 |
| Pathways | MAPK |
| GeneCards | STMN1 |
| Human Protein Atlas | STMN1 |
| Site | Kinase |
| Ser16 | PKA, CaMKII |
| Ser25 | CDK1, ERK |
| Ser38 | MAPK, PKA |
| Ser63 | PKA, PKC |
| Associated Diseases | Alzheimer's disease, Parkinson's disease, ALS |
| Interactions | ERK1, ERK, CANCER, MEK, ERK1/2 |
| KG Connections | 40 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
STMN1["<b>STMN1</b>"]
Ms{"Ms"}
STMN1 -->|"therapeutic target"| Ms
Cancer{"Cancer"}
STMN1 -->|"inhibits"| Cancer
Tumor{"Tumor"}
STMN1 -->|"inhibits"| Tumor
Apoptosis(["Apoptosis"])
STMN1 -->|"therapeutic target"| Apoptosis
Mapk(["Mapk"])
STMN1 -->|"associated with"| Mapk
neurodegeneration["neurodegeneration"]
STMN1 -->|"implicated in"| neurodegeneration
SMC1A["SMC1A"]
SMC1A -->|"regulates"| STMN1
ERK["ERK"]
ERK -->|"inhibits"| STMN1
SPR["SPR"]
SPR -->|"therapeutic target"| STMN1
CANCER["CANCER"]
CANCER -->|"inhibits"| STMN1
ERK1["ERK1"]
ERK1 -->|"inhibits"| STMN1
APOPTOSIS["APOPTOSIS"]
APOPTOSIS -->|"therapeutic target"| STMN1
style STMN1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Ms | therapeutic_target | disease | 0.65 |
| Cancer | inhibits | disease | 0.65 |
| Tumor | inhibits | disease | 0.65 |
| Traumatic Brain Injury | expressed_in | disease | 0.65 |
| GAP43 | expressed_in | gene | 0.60 |
| HSPE1 | expressed_in | gene | 0.60 |
| SNCG | expressed_in | gene | 0.60 |
| MAPT | expressed_in | gene | 0.60 |
| NDUFS6 | expressed_in | gene | 0.60 |
| SNCB | expressed_in | gene | 0.60 |
| Apoptosis | therapeutic_target | pathway | 0.60 |
| Mapk | associated_with | pathway | 0.60 |
| BRAIN INJURY | expressed_in | gene | 0.60 |
| AND | expressed_in | gene | 0.60 |
| LDHB | expressed_in | gene | 0.60 |
| Epithelial | therapeutic_target | cell_type | 0.60 |
| frontotemporal dementia | interacts_with | disease | 0.60 |
| Temporal Lobe | expressed_in | brain_region | 0.55 |
| Frontal Lobe | expressed_in | brain_region | 0.55 |
| Cortex | expressed_in | brain_region | 0.55 |
| Proteins | expressed_in | protein | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| SMC1A | regulates | gene | 0.80 |
| SPR | therapeutic_target | gene | 0.60 |
| ERK1 | inhibits | gene | 0.60 |
| NDUFS6 | expressed_in | gene | 0.60 |
| MAPT | expressed_in | gene | 0.60 |
| SNCB | expressed_in | gene | 0.60 |
| SNCG | expressed_in | gene | 0.60 |
| HSPE1 | expressed_in | gene | 0.60 |
| GAP43 | expressed_in | gene | 0.60 |
| ERK | inhibits | gene | 0.60 |
| CANCER | inhibits | gene | 0.60 |
| APOPTOSIS | therapeutic_target | gene | 0.60 |
| LDHB | expressed_in | gene | 0.60 |
| GENES | expressed_in | gene | 0.60 |
| MEK | inhibits | gene | 0.60 |
| MAPK | associated_with | gene | 0.60 |
| ERK1/2 | inhibits | gene | 0.60 |
| SNCB | co_expressed_with | gene | 0.50 |
| SNCG | co_expressed_with | protein | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||