gene

STMN1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about STMN1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

40Connections
0Hypotheses
0Analyses
21Outgoing
19Incoming

Summary

Comprehensive coverage of STMN1 (Stathmin 1) in microtubule dynamics, neuronal development, synaptic plasticity, and neurodegenerative diseases including AD/PD/ALS.

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🧬 Gene Info
Gene SymbolSTMN1
Full NameStathmin 1
Chromosome1p36.11
Functionis a 143-amino acid phosphoprotein that serves as a master regulator of microtubule dynamics in all eukaryotic cells.
Molecular Weight19 kDa
Amino Acids149 aa
Exons5
PathwaysMAPK
GeneCardsSTMN1
Human Protein AtlasSTMN1
SiteKinase
Ser16PKA, CaMKII
Ser25CDK1, ERK
Ser38MAPK, PKA
Ser63PKA, PKC
Associated DiseasesAlzheimer's disease, Parkinson's disease, ALS
InteractionsERK1, ERK, CANCER, MEK, ERK1/2
KG Connections40 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Wiki Pages (15)

Knowledge base pages for this entity

Canonical Page

STMN1 — Stathmin 1

gene · 1889 words

TUBB — Tubulin Beta Class I

gene · 3103 words

Stathmin-2 (SCG10)

protein · 3087 words

stathmin

protein · 2147 words

Dentate Gyrus Granule Cells

cell · 2078 words

SNCG Gene — Gamma-Synuclein

gene · 1656 words

Pathway Diagram

graph TD
    STMN1["<b>STMN1</b>"]
    Ms{"Ms"}
    STMN1 -->|"therapeutic target"| Ms
    Cancer{"Cancer"}
    STMN1 -->|"inhibits"| Cancer
    Tumor{"Tumor"}
    STMN1 -->|"inhibits"| Tumor
    Apoptosis(["Apoptosis"])
    STMN1 -->|"therapeutic target"| Apoptosis
    Mapk(["Mapk"])
    STMN1 -->|"associated with"| Mapk
    neurodegeneration["neurodegeneration"]
    STMN1 -->|"implicated in"| neurodegeneration
    SMC1A["SMC1A"]
    SMC1A -->|"regulates"| STMN1
    ERK["ERK"]
    ERK -->|"inhibits"| STMN1
    SPR["SPR"]
    SPR -->|"therapeutic target"| STMN1
    CANCER["CANCER"]
    CANCER -->|"inhibits"| STMN1
    ERK1["ERK1"]
    ERK1 -->|"inhibits"| STMN1
    APOPTOSIS["APOPTOSIS"]
    APOPTOSIS -->|"therapeutic target"| STMN1
    style STMN1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (21)

TargetRelationTypeStr
Mstherapeutic_targetdisease0.65
Cancerinhibitsdisease0.65
Tumorinhibitsdisease0.65
Traumatic Brain Injuryexpressed_indisease0.65
GAP43expressed_ingene0.60

Incoming (19)

SourceRelationTypeStr
SMC1Aregulatesgene0.80
SPRtherapeutic_targetgene0.60
ERK1inhibitsgene0.60
NDUFS6expressed_ingene0.60
MAPTexpressed_ingene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found