Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Colorectal Cancer: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Associated Genes | INFLAMMATION, CANCER, PER, PI3K, AKT, MTOR, AGING, DNA |
| Therapeutic Agents | Sijunzi Decoction, PI3K/Akt/mTOR Inhibitors, Hydroxytyrosol, Pi3K/Akt/Mtor-Targeted Agents, cardamom nanoemulsion, Theranekron |
| KG Connections | 787 knowledge graph edges |
| Databases | OMIMOrphanetClinicalTrialsPubMed |
Knowledge base pages for this entity
graph TD
Colorectal_Cancer["<b>Colorectal Cancer</b>"]
Cancer{"Cancer"}
Colorectal_Cancer -->|"associated_with"| Cancer
Inflammation{"Inflammation"}
Colorectal_Cancer -->|"associated_with"| Inflammation
Als{"Als"}
Colorectal_Cancer -->|"activates"| Als
Metastasis["Metastasis"]
Colorectal_Cancer -->|"activates"| Metastasis
INFLAMMATION(["INFLAMMATION"])
INFLAMMATION -->|"associated_with"| Colorectal_Cancer
CANCER(["CANCER"])
CANCER -->|"associated_with"| Colorectal_Cancer
style Colorectal_Cancer fill:#1a3a4a,stroke:#ef5350,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Cancer | associated_with | disease | 1.00 |
| Inflammation | associated_with | disease | 1.00 |
| Cancer | activates | disease | 1.00 |
| Als | activates | disease | 1.00 |
| Inflammation | activates | disease | 1.00 |
| Metastasis | activates | pathway | 1.00 |
| Cancer | inhibits | disease | 1.00 |
| Tumor | associated_with | disease | 1.00 |
| Autophagy | activates | pathway | 1.00 |
| Apoptosis | activates | pathway | 1.00 |
| Tumor | activates | disease | 1.00 |
| Cancer | therapeutic_target | disease | 1.00 |
| Tumor | therapeutic_target | disease | 1.00 |
| Als | therapeutic_target | disease | 1.00 |
| Immunotherapy | therapeutic_target | pathway | 1.00 |
| Metastasis | therapeutic_target | pathway | 1.00 |
| Drug Resistance | therapeutic_target | pathway | 1.00 |
| Tumor | inhibits | disease | 1.00 |
| Tumor Microenvironment | therapeutic_target | pathway | 1.00 |
| Cancer | causes | disease | 1.00 |
| Tumor Microenvironment | activates | pathway | 1.00 |
| Cancer | regulates | disease | 1.00 |
| Als | inhibits | disease | 1.00 |
| Invasion | therapeutic_target | pathway | 1.00 |
| Apoptosis | inhibits | pathway | 1.00 |
| Cancer | contributes_to | disease | 0.95 |
| Inflammation | therapeutic_target | disease | 0.95 |
| Gastric Cancer | associated_with | disease | 0.95 |
| Als | associated_with | disease | 0.95 |
| White Population | associated_with | phenotype | 0.90 |
| Mtor | activates | pathway | 0.90 |
| Invasion | activates | pathway | 0.90 |
| Glycolysis | activates | pathway | 0.90 |
| Wnt | activates | pathway | 0.90 |
| Checkpoint Inhibitor | therapeutic_target | pathway | 0.90 |
| Immune Checkpoint | therapeutic_target | pathway | 0.90 |
| Angiogenesis | therapeutic_target | pathway | 0.90 |
| Metastasis | inhibits | pathway | 0.90 |
| Cancer | treats | disease | 0.85 |
| Carcinoma | therapeutic_target | disease | 0.85 |
| Inflammatory Bowel Disease | associated_with | disease | 0.85 |
| Cancer | biomarker_for | disease | 0.85 |
| Cancer | implicated_in | disease | 0.85 |
| Digestive System Cancers | associated_with | disease | 0.80 |
| Pi3K/Akt | activates | pathway | 0.80 |
| Apoptosis | therapeutic_target | pathway | 0.80 |
| Mapk | activates | pathway | 0.80 |
| Ferroptosis | activates | pathway | 0.80 |
| Microbiota | activates | pathway | 0.80 |
| Nf-Κb | activates | pathway | 0.80 |
| Source | Relation | Type | Str |
|---|---|---|---|
| INFLAMMATION | associated_with | gene | 1.00 |
| CANCER | associated_with | gene | 1.00 |
| INFLAMMATION | activates | gene | 1.00 |
| CANCER | activates | gene | 1.00 |
| Tumor | activates | disease | 1.00 |
| CANCER | inhibits | gene | 1.00 |
| ROS | activates | gene | 1.00 |
| APOPTOSIS | activates | gene | 1.00 |
| AUTOPHAGY | activates | gene | 1.00 |
| AKT | activates | gene | 1.00 |
| GENES | therapeutic_target | gene | 1.00 |
| CANCER | therapeutic_target | gene | 1.00 |
| CANCER | contributes_to | gene | 1.00 |
| KRAS | activates | gene | 1.00 |
| MYC | activates | gene | 1.00 |
| INFLAMMATION | therapeutic_target | gene | 1.00 |
| GENES | associated_with | gene | 1.00 |
| DNA | activates | gene | 1.00 |
| CANCER | causes | gene | 1.00 |
| Tumor | therapeutic_target | disease | 1.00 |
| CANCER | regulates | gene | 1.00 |
| APOPTOSIS | inhibits | gene | 1.00 |
| EGFR | therapeutic_target | gene | 1.00 |
| CANCER | treats | gene | 0.95 |
| AKT | inhibits | gene | 0.95 |
| PI3K | activates | gene | 0.95 |
| OVERVIEW | therapeutic_target | gene | 0.95 |
| DNA | associated_with | gene | 0.95 |
| RAS | activates | gene | 0.95 |
| GENES | activates | gene | 0.95 |
| TP53 | associated_with | gene | 0.95 |
| KRAS | therapeutic_target | gene | 0.95 |
| PI3K | therapeutic_target | gene | 0.95 |
| AKT | therapeutic_target | gene | 0.95 |
| STAT3 | inhibits | gene | 0.95 |
| CANCER | biomarker_for | gene | 0.95 |
| CANCER | implicated_in | gene | 0.95 |
| Sijunzi Decoction | treats | drug | 0.95 |
| PI3K/Akt/mTOR | involved_in | pathway | 0.95 |
| USP36 | associated_with | protein | 0.95 |
| USP36 | promotes | enzyme | 0.95 |
| HSP90AA1 | involved_in | protein | 0.90 |
| AKT1 | associated_with | gene | 0.90 |
| Pi3K/Akt/Mtor-Targeted Agents | treats | drug | 0.90 |
| Precancerous Lesion Evolution | contributes_to | process | 0.90 |
| Partial Colectomy | treats | process | 0.90 |
| BCL2 | inhibits | gene | 0.85 |
| MTOR | activates | gene | 0.85 |
| NRF2 | treats | gene | 0.85 |
| AKT | regulates | gene | 0.85 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||